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Synthesis and Properties of Composites Based on Hydroxyapatite, Magnetite, and 2-Arylaminopyrimidine Derivatives

  • NANOBIOMEDICINE AND NANOPHARMACEUTICALS
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Abstract

This paper proposes a method of one-step synthesis of a magnetic nanocomposite based on hydroxyapatite and iron oxide using the modified stoichiometric titration method. The possibility is shown of modifying the proposed method for one-step synthesis of the magnetic nanocomposite containing bioactive compound (BAC) from a 2-arylaminopyrimidine series. The composition, morphology, structure, and magnetic characteristics of the nanocomposites with and without BAC have been evaluated. The kinetics of the BAC release in a solution simulating the stomach environment has been studied. The reported composite is promising for biomedical applications as a tool for targeted drug delivery.

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REFERENCES

  1. J. P. Pessan, A. Paula, M. Vieira, et al., Antibiotics 7, 1 (2018).

    Google Scholar 

  2. P. Tartaj, P. Morales, S. Veintemillas-Verdaguer, et al., J. Phys. D: Appl. Phys. 36, 182 (2003).

    Article  Google Scholar 

  3. L. Mango, Height. J. Cancer. Sci. Res. 1, 001 (2017).

  4. S. Mondal, P. Manivasagan, S. Bharathiraja, et al., Nano 2, 8389 (2017).

    Google Scholar 

  5. S. Panseri, C. Cunha, T. D. Alessandro, et al., J. Nanobiotechnol. 7, 4 (2012).

    Google Scholar 

  6. M. A. Orlova, A. L. Nikolaev, T. P. Trofimova, et al., Vestn. Ross. Med. Univ. 6, 94 (2018).

    Google Scholar 

  7. C. T. Yang, K. Y. Li, F. Q. Meng, et al., Nanotechnology 29, 375101 (2018).

    Article  Google Scholar 

  8. B. L. Seal, T. C. Otero, and A. Panitch, Mater. Sci. Eng. 34, 147 (2001).

    Article  Google Scholar 

  9. B. Govindan, B. S. Latha, P. Nagamony, et al., Nanomaterials 7, 1 (2017).

    Article  CAS  Google Scholar 

  10. H. Wu and F. Lin, Biomed. Eng. Appl. Basis. Commun. 22, 33 (2010).

    Article  CAS  Google Scholar 

  11. Zh. V. Ignatovich, Yu. V. Sinyutich, K. N. Gusak, and E. V. Koroleva, Russ. J. Org. Chem. 51, 1449 (2015).

    Article  CAS  Google Scholar 

  12. E. V. Koroleva, Z. I. Ignatovich, Y. V. Sinyutich, et al., Russ. J. Org. Chem. 52, 139 (2016).

    Article  CAS  Google Scholar 

  13. S. Scialla, B. Palazzo, A. Barca, et al., Mater. Sci. Eng. C 76, 1166 (2017).

    Article  CAS  Google Scholar 

  14. B. Horváth, M. Rigó, S. Guba, et al., Heliyon 5, 01507 (2019).

    Article  Google Scholar 

  15. R. Blue and N. Ions, Sci. World. J. 2, 1 (2015).

    Google Scholar 

  16. E. Boanini, M. Gazzano, and A. Bigi, Acta Biomater. 6, 1882 (2010).

    Article  CAS  Google Scholar 

  17. S. Lang, M. Gregor, C. Wolf-Brandstetter, et al., Appl. Phys. Lett. 98, 1 (2011).

    Google Scholar 

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ACKNOWLEDGMENTS

The authors are grateful to Prof. Dr. Andrij Pich (Laboratory of Functional and Interactive Polymers, DWI Leibniz Institute of Interactive Materials, Aachen, Germany) for providing study by STEM.

Funding

This work was supported by the Deutsche Forschungsgemeinschaft, project no. 419853195 “Functional magnetic nanotubes decorated with stimuli-responsive polymer coatings.”

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Authors and Affiliations

  1. Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    Zh. V. Ignatovich, Kh. A. Novik, A. V. Abakshonok, E. V. Koroleva & A. E. Shumskaya

  2. Scientific-Practical Materials Research Centre, National Academy of Sciences of Belarus, 220072, Minsk, Belarus

    E. Yu. Kaniukov

Authors
  1. Zh. V. Ignatovich
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  2. Kh. A. Novik
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  3. A. V. Abakshonok
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  4. E. V. Koroleva
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  5. A. E. Shumskaya
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  6. E. Yu. Kaniukov
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Corresponding author

Correspondence to A. E. Shumskaya.

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Translated by D. Kharitonov

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Ignatovich, Z.V., Novik, K.A., Abakshonok, A.V. et al. Synthesis and Properties of Composites Based on Hydroxyapatite, Magnetite, and 2-Arylaminopyrimidine Derivatives. Nanotechnol Russia 14, 600–606 (2019). https://doi.org/10.1134/S1995078019060089

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  • DOI: https://doi.org/10.1134/S1995078019060089

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