SpringerLink
Log in

Stimuli-Responsive Hydrogel Based on Poly((2-Dimethylamino)Ethyl Methacrylate) Grafted onto Sodium Alginate as a Drug Delivery System

  • MEDICAL POLYMERS
  • Published:
Polymer Science, Series B Aims and scope Submit manuscript

Abstract

In this article, a novel stimuli hydrogel was prepared by simultaneous formation of iron oxide nanoparticles (IONs) and crosslinking of poly((2-dimethylamino)ethyl methacrylate) grafted onto sodium alginate. The structural and morphological properties of hydrogel were characterized by Fourier transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscopy with energy dispersive X‑ray analysis, atomic force microscopy, and transmission electron microscopy techniques. Swelling capacity was measured at different temperatures, salts solutions with different multivalent, different pH, and magnetic field to assess the sensitivity of iron oxide nanocomposite hydrogel (ION-hydrogel). Moreover, drug loading and release efficiency were investigated at different pH, temperature, and magnetic field using doxorubicin as an anticancer drug. Drug release studies have shown significant dependence on simulated physiological pH values and external alternative magnetic fields. These results suggested that the ION-hydrogel could be a promising candidate for biomedical applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.

Similar content being viewed by others

REFERENCES

  1. S. L. Easo and P. V. Mohanan, Carbohydr. Polym. 92, 726 (2013).

  2. T. Gordon, B. Perlstein, O. Houbara, I. Felner, E. Banin, and S. Margel, Colloids Surf., A 374, 1 (2011).

    Article  CAS  Google Scholar 

  3. C. S. Kumar and F. Mohammad, Adv. Drug Delivery Rev. 63, 789 (2011).

  4. A. Hassanjani-Roshan, M. R. Vaezi, A. Shokuhfar, and Z. Rajabali, Particuology 9, 95 (2011).

    Article  CAS  Google Scholar 

  5. M. Levy, N. Luciani, D. Alloyeau, D. Elgrabli, V. Deveaux, C. Pechoux, and C. Factor, Biomaterials 32, 3988 (2011).

    Article  CAS  PubMed  Google Scholar 

  6. A. Figuerola, R. Di Corato, L. Manna, and T. Pellegrino, Pharm. Res. 62, 126 (2010).

    Article  CAS  Google Scholar 

  7. Q. Guo, Z. Zhang, X. Ma, K. **g, M. Shen, N. Yu, and D. D. Dionysiou, Sep. Purif. Technol. 175, 305‏ (2017).

  8. J. Choubey and A. K. Bajpai, J. Mater. Sci.: Mater. Med. 21, 1573 (2010).

  9. A. Galbiati, C. Tabolacci, B. Morozzo Della Rocca, P. Mattioli, S. Beninati, G. Paradossi, and A. Desideri, Bioconjugate Chem. 22, 1066 (2011).

  10. H. Hezaveh and I. I. Muhamad, Chem. Eng. Res. Des. 91, 508 (2013).

    Article  CAS  Google Scholar 

  11. M. Kurdtabar, H. Nezam, G. R. Bardajee, M. Dezfulian, and H. Salimi, Polym. Sci., Ser. B 60, 231 (2018).

    Article  CAS  Google Scholar 

  12. D. C. Manatunga, R. M. de Silva, K. N. de Silva, N. de Silva, S. Bhandari, Y. K. Yap, and N. P. Costha, Eur. J. Pharm. Biopharm.117, 29 (2017).

    Article  CAS  PubMed  Google Scholar 

  13. A. Bumajdad, S. Ali, and A. Mathew, J. Colloid Interface Sci. 355, 282 (2011).

  14. S. Laurent, S. Dutz, U. O. Häfeli, and M. Mahmoudi, Adv. Colloid Interface Sci. 166, 8 (2011).

  15. H. Cui,Y. Liu, and W. Ren, Adv. Powder Technol. 24, 93 (2013).

  16. P. N. R. Kishore and P. Jeevanandam, J. Alloys Compd. 522, 51 (2012).

    Article  CAS  Google Scholar 

  17. D. Bennet and S. Kim, in Application of Nanotechnology in Drug Delivery, Ed. By A. D. Sezer (IntechOpen, ‏2014), Chap. 8.

    Google Scholar 

  18. I. I. Muhamad, S. Selvakumaran, and N. A. M. Lazim, Nanomedicine 287, 287 (2014).

    Google Scholar 

  19. N. S. Re**old, M. Muthunarayanan, V. V. Divyarani, P. R. Sreerekha, K. P. Chennazhi, S. V. Nair, and R. Jayakumar, J. Colloid Interface Sci. 360, 39 (2011).

    Article  PubMed  CAS  Google Scholar 

  20. G. Tiwari, R. Tiwari, B. Sriwastawa, L. Bhati, S. Pandey, P. Pandey, and S. K. Bannerjee, Int. J. Pharm. I-nvest. 2, 2 (2012).

  21. S. Patra, E. Roy, P. Karfa, S. Kumar, R. Madhuri, and P. K. Sharma, ACS Appl. Mater. Interfaces 7, 9235 (2015).

    Article  CAS  PubMed  Google Scholar 

  22. S. Alimirzalu, A. Akbarzadeh, M. Abbasian, S. Alimohammadi, S.Davaran, Y. Hanifehpour, and S. W. Joo, Asian Pac. J. Cancer Prev. 15, 49 (2014).

    Article  PubMed  Google Scholar 

  23. R. Wu, J. Qu, H. He, and Y. Yu, Appl. Catal., B 48, 49‏ (2004).

  24. P. Li, D. E. Miser, S. Rabiei, R. T. Yadav, and M. R.Hajaligol, Appl. Catal., B 43, 151 (2003).

  25. M. S. Onyango, Y. Kojima, H. Matsuda, and A. Ochi-eng, J. Chem. Eng. Jpn. 36, 1516 (2003).

    Article  CAS  Google Scholar 

  26. L. C. Oliveira, D. I. Petkowicz, A. Smaniotto, and S. B. Pergher, Water Res. 38, 3699 (2004).

    Article  CAS  PubMed  Google Scholar 

  27. H. Zeng, J. Li, J. P. Liu, Z. L. Wang, and S. Sun, Nature 420, 395 (2002).

    Article  CAS  PubMed  Google Scholar 

  28. O. Shekhah, W. Ranke, A. Schüle, G. Kolios, and R. Schlögl, Angew. Chem., Int. Ed. 42, 5760 (2003).

    Article  CAS  Google Scholar 

  29. J. Zhang, Y. Wang, H. Ji, Y. Wei, N. Wu, B. Zuo, and Q. Wang, J. Catal. 229, 114 (2005).

    Article  CAS  Google Scholar 

  30. J. Chen, L. Xu, W. Li, and X. Gou, Adv. Mater. 17, 582 (2005).

    Article  CAS  Google Scholar 

  31. A. Jordan, R. Scholz, K. Maier-Hauff, M. Johannsen, P. Wust, J. Nadobny, and W. Lanksch, J. Magn. Magn. Mater. 225, 118 (2001).

    Article  CAS  Google Scholar 

  32. S. Mancarella, V. Greco, F. Baldassarre, D. Vergara, M. Maffia, and S. Leporatti, Macromol. Biosci. 15, 1365 (2015).

    Article  CAS  PubMed  Google Scholar 

  33. F. Chen, C. Li, Y. J. Zhu, X. Y. Zhao, B. Q. Lu, and J. Wu, Biomater. Sci. 1, 1074 (2013).

    Article  CAS  PubMed  Google Scholar 

  34. S. Manju, C. P. Sharma, and K. Sreenivasan, J. Mater. Chem. 21, 15708 (2011).

    Article  CAS  Google Scholar 

  35. L. Zhou, B. He, and F. Zhang, ACS Appl. Mater. Interfaces 4, 192 (2011).

    Article  PubMed  CAS  Google Scholar 

  36. H. Y. Zhu, Y. Q. Fu, R. Jiang, J. Yao, L. **ao, and G. M. Zeng, Bioresour. Technol. 105, 24 (2012).

    Article  CAS  PubMed  Google Scholar 

  37. R. T. Olsson, M. A. Samir, G. Salazar-Alvarez, L. Belova, V. Ström, L. A. Berglund, and U. W. Gedde, Nat. Nanotechnol. 5, 584 (2010).

    Article  CAS  PubMed  Google Scholar 

  38. G. R. Bardajee, Z. Hooshyar, M. J. Asli, F. E. Shahidi, and N. Dianatnejad, Mater. Sci. Eng., C 36, 277 (2014).

    Article  CAS  Google Scholar 

  39. G. R. Bardajee and Z. Hooshyar, Carbohydr. Polym. 101, 741 (2014).

    Article  CAS  PubMed  Google Scholar 

  40. G. R. Bardajee and Z. Hooshyar, J. Polym. Res. 20, 298 (2013).

    Article  CAS  Google Scholar 

  41. M. George and T. E. Abraham, Int. J. Pharm. 335, 123 (2007).

    Article  CAS  PubMed  Google Scholar 

  42. J. An, X. Yuan, Q. Luo, and D. Wang, Polym. Int. 59, 62 (2010).

    Article  CAS  Google Scholar 

  43. L. Zhou, B. He, and F. Zhang, ACS Appl. Mater. Interfaces 4, 192(2012).

    Article  CAS  PubMed  Google Scholar 

  44. R. Barbucci, G. Giani, S. Fedi, S. Bottari, and M. Ca-solaro, Acta Biomater. 8, 4244 (2012).

    Article  CAS  PubMed  Google Scholar 

  45. G. Giani, S. Fedi, and R. Barbucci, Polymers 4, 1157 (2012).

    Article  CAS  Google Scholar 

  46. M. Czaun, L. Hevesi, M. Takafujia, and H. Ihara, Chem. Commun. 1–3, 2124 (2008).

    Article  CAS  Google Scholar 

  47. R. Barbucci, D. Pasqui, G. Giani, M. D. Cagna, M. Fini, and R. Giardino, Soft Matter 7, 5558 (2011).

    Article  CAS  Google Scholar 

  48. D. Pasqui, A. Atrei, G. Giani, M.D. Cagna, and R. Barbucci, Mater. Lett. 65, 392 (2011).

    Article  CAS  Google Scholar 

  49. S. H. Yu, H. Y. Hsieh, J. C. Pang, D. W. Tang, C. M. Shih, M. L. Tsai, and F. L. Mi, Food Hydrocolloids 32, 9 (2013).

    Article  CAS  Google Scholar 

  50. J. Zhang, A. Li, and A. Wang, Carbohydr. Polym. 65, 150 (2006).

    Article  CAS  Google Scholar 

  51. K. Li, L. Yu, X. Liu, C. Chen, Q. Chen, and J. Ding, Biomaterials 34, 2834 (2013).

    Article  CAS  PubMed  Google Scholar 

  52. K. Kabiri, H. Omidian, S. A. Hashemi, and M. J. Zohuriaan-Mehr, Eur. Polym. J. 39, 1341 (2003).

    Article  CAS  Google Scholar 

  53. Y. Wang, Z. Zhang, L. Xu, X. Li, and H. Chen, Colloids Surf., B 104, 163 (2013).

    Article  CAS  Google Scholar 

  54. G. R. Mahdavinia, A. Pourjavadi, H. Hosseinzadeh, and M. J. Zohuriaan, Eur. Polym. J. 40, 1399 (2004).

    Article  CAS  Google Scholar 

  55. T. Y. Liu, S. H. Hu, K. H. Liu, D. M. Liu, and S. Y. Chen, J. Magn. Magn. Mater. 304, 397 (2006).

    Article  CAS  Google Scholar 

  56. Y. Wang, A. Dong, Z. Yuan, and D. Chen, Colloids Surf., A 415, 68 (2012).

    Article  CAS  Google Scholar 

  57. T. Y. Liu, S. H. Hu, D. M. Liu, and S. Y. Chen, Langmuir 22, 5974 (2006).

    Article  CAS  PubMed  Google Scholar 

  58. O. Philippova, A. Barabanova, V. Molchanov, and A. Khokhlov, Eur. Polym. J. 47, 542 (2011)

    Article  CAS  Google Scholar 

  59. K. Kabiriand and M. J. Zohuriaan-Mehr, Polym. Adv. Technol. 14, 438 (2003).

  60. G. R. Bardajee, F. Mizani, and S. S. Hosseini, J. Polym. Res. 24, 48 (2017).

    Article  CAS  Google Scholar 

  61. A. Khan and A. M. El-Toni, Mater. Lett. 89, 12 (2012).

    Article  CAS  Google Scholar 

  62. T. Y. Liu, S. H. Hu, K. H. Liu, D. M. Liu, and S. Y. Chen, J. Magn. Magn. Mater. 304, 397 (2006).

    Article  CAS  Google Scholar 

  63. A. Pourjavadi, H. Hosseinzadeh, and R. Mazidi, J. Appl. Polym. Sci. 98, 255 (2005).

    Article  CAS  Google Scholar 

  64. A. Pourjavadi, R. Soleyman, G. R. Bardajee, and S. Ghavami, Bull. Korean Chem. Soc. 30, 2680 (2009).

    Article  CAS  Google Scholar 

  65. G. R. Bardajee, A. Pourjavadi, N. Sheikh, and M. S. Amini-Fazl, Radiat. Phys. Chem. 77, 131 (2008).

    Article  CAS  Google Scholar 

  66. M. Dadsetan, K. E. Taylor, C. Yong, Ž. Bajzer, L. Lu, and M. J. Yaszemski, Acta Biomater. 9, 5438 (2013).

    Article  CAS  PubMed  Google Scholar 

  67. Y. Bae, N. Nishiyama, S. Fukushima, H. Koyama, M. Yasuhiro, and K. Kataoka, Bioconjugate Chem. 16, 122 (2005).

    Article  CAS  Google Scholar 

Download references

Funding

This research was supported by budget of Research Projects of Karaj Branch, Islamic Azad University.

Author information

Authors and Affiliations

  1. Department of Chemistry, Karaj Branch, Islamic Azad University, 31485-313, Karaj, Iran

    M. Kurdtabar

  2. Department of Chemistry, Payame Noor University, 19395-3697, Tehran, Iran

    G. Rezanejade Bardajee

Authors
  1. M. Kurdtabar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Rezanejade Bardajee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Kurdtabar.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurdtabar, M., Rezanejade Bardajee, G. Stimuli-Responsive Hydrogel Based on Poly((2-Dimethylamino)Ethyl Methacrylate) Grafted onto Sodium Alginate as a Drug Delivery System. Polym. Sci. Ser. B 61, 642–652 (2019). https://doi.org/10.1134/S1560090419050099

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1560090419050099

Search

Navigation