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Synthesis of Cage Acylamino Derivatives in Nitric Acid Medium

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Abstract

An efficient procedure has been developed for the synthesis of secondary amides by the Ritter reaction of cage substrates with a wide series of nitriles in fuming nitric acid and its mixtures.

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ACKNOWLEDGMENTS

This study was performed using the facilities of the “Study of Physicochemical Properties of Compounds and Materials” joint center at the Samara State Technical University. Compounds 1–8 and 47 were taken from the collection of chemicals of the Organic Chemistry Department (Samara State Technical University). Fluorinated adamantane derivatives were provided by A.M. Aleksandrov (Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine).

Funding

This study was financially supported by the Ministry of Science and Higher Education of the Russian Federation in the framework of the project part of state assignment no. 0778-2020-0005.

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  1. Samara State Technical University, 443100, Samara, Russia

    Yu. N. Klimochkin, M. V. Leonova, E. A. Ivleva, A. I. Kazakova & M. S. Zaborskaya

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  1. Yu. N. Klimochkin
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  2. M. V. Leonova
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  3. E. A. Ivleva
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  4. A. I. Kazakova
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Correspondence to E. A. Ivleva.

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Klimochkin, Y.N., Leonova, M.V., Ivleva, E.A. et al. Synthesis of Cage Acylamino Derivatives in Nitric Acid Medium. Russ J Org Chem 57, 1–12 (2021). https://doi.org/10.1134/S1070428021010012

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