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Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

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Abstract

Сopper(II) nitrate reacts in ethanol with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide H2L in an 1 : 1 molar ratio to form the coordination compound Cu(HL)NO3·H2O. The introduction of amines [imidazole (Im), 3,5-dibromopyridine (3,5-Br2Py), and 4-methylpyridine (4-Pic)] into the reaction mixture in a molar ratio 1 : 1 : 2 leads to the formation of CuA(HL)NO3·nH2O [A = Im, 3,5-Br2Py, 4-Pic; n = 0, 3] complexes. The structure of the obtained compounds was determined by X-ray structural analysis. The synthesized complexes exhibit antimicrobial, antifungal, antioxidant, and anticancer activities.

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ACKNOWLEDGMENTS

The authors express their gratitude to G.G. Balan and O.S. Burduniuc (N. Testemitsanu State Medical and Pharmaceutical University) for their assistance in conducting biological tests of synthesized substances.

Funding

The work was carried out within the framework of the state programs of the Republic Moldova (projects 20.80009.5007.10 and 20.80009.5007.15).

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Authors and Affiliations

  1. State University of Moldova, MD2009, Chisinau, Moldova

    А. P. Gulea, V. О. Graur, Ia. I. Ulchina, O. S. Garbuz & V. I. Tsapkov

  2. Institute of Applied Physics, MD2028, Chisinau, Moldova

    P. N. Bourosh

  3. Institute of Chemistry, MD2028, Chisinau, Moldova

    V. A. Smaglii

  4. Institute of Zoology, MD2028, Chisinau, Moldova

    O. S. Garbuz

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  1. А. P. Gulea
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  2. V. О. Graur
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  3. Ia. I. Ulchina
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  4. P. N. Bourosh
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  5. V. A. Smaglii
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  6. O. S. Garbuz
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  7. V. I. Tsapkov
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Corresponding author

Correspondence to Ia. I. Ulchina.

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Gulea, А.P., Graur, V.О., Ulchina, I.I. et al. Synthesis, Structure, and Biological Activity of Mixed-Ligand Amine-Containing Copper(II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide. Russ J Gen Chem 91, 98–107 (2021). https://doi.org/10.1134/S1070363221010114

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