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Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

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Abstract

A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

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REFERENCES

  1. Neutron Capture Therapy., Principles and Applications, Sauerwein, W.A.G., Wittig, A., Moss, R., and Nakagawa, Y., Eds., Heidelberg: Springer, 2012.

    Google Scholar 

  2. Ali, F., Hosmane, N.S., and Zhu, Y., Mol. J., 2020, vol. 25, p. 828.

    Article  CAS  Google Scholar 

  3. Zaboronok, A., Yamamoto, T., Nakai, K., et al., Appl. Radiat. Isotopes, 2015, vol. 106, pp. 181–184.

    Article  CAS  Google Scholar 

  4. Barth, R.F., Mi, P., and Yang, W.,Cancer Commun., 2018, vol. 38, no. 1, p. 35.

    Article  Google Scholar 

  5. Hutchinson, M. and Widom, M., Comput. Phys. Commun., 2012, vol. 183, no. 7, pp. 1422–1436.

    Article  CAS  Google Scholar 

  6. Nakamura, H., El-Zaria, M.E., and Ban, H.S., Chem.-Eur. J., 2010, vol. 16, no. 5, pp. 1543–1552.

    Article  Google Scholar 

  7. Uspenskii, S.A., Khaptakhanova, P.A., Zaboronok, A.A., Kurkin, T.S., et al., RF Patent 2720458 (at 06.06.2019), April 30, 2020, PCT/RU2020/000177.

  8. Yoshida, F., Matsumura, A., Shibata, Y., et al., Cancer Lett., 2002, vol. 187, no. 1/2, pp. 135–141.

    Article  CAS  Google Scholar 

  9. Taskaev, S.Yu., Fiz. Elem. Chast. At. Yadra, 2019, vol. 50, no. 5, pp. 657–669.

    Google Scholar 

Download references

ACKNOWLEDGMENTS

The authors are grateful to Corresponding Member of the RAS A.N. Ozerin for active discussion of the results of this study.

Funding

This work was supported by the Russian Science Foundation (project no. 19-72-30005) and Fundamental Scientific Research Program (project no. 0310-2019-0004), and also partly supported by a Grant-in-Aid for Scientific Research (B) [18H02909] from the Japanese Ministry of Education, Culture, Sports, Science, and Technology and by the Basic Research Support Program (Type A) in 2019 of University of Tsukuba, Japan.

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Authors and Affiliations

  1. Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 117393, Moscow, Russia

    S. A. Uspenskii, P. A. Khaptakhanova & T. S. Kurkin

  2. Moscow Institute of Physics and Technology, 9141701, Dolgoprudny, Moscow oblast, Russia

    S. A. Uspenskii & P. A. Khaptakhanova

  3. University of Tsukuba, Tennodai, 1-1-1, 305-8575, Tsukuba, Ibaraki, Japan

    A. A. Zaboronok & Matsumura Akira

  4. Novosibirsk State University, 630090, Novosibirsk, Russia

    A. A. Zaboronok & V. V. Kanygin

  5. Institute of Molecular and Cellular Biology, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    O. Yu. Volkova, L. V. Mechetina & A. V. Taranin

  6. Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    S. Yu. Taskaev

Authors
  1. S. A. Uspenskii
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  2. P. A. Khaptakhanova
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  3. A. A. Zaboronok
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  4. T. S. Kurkin
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  5. O. Yu. Volkova
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  6. L. V. Mechetina
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  7. A. V. Taranin
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  8. V. V. Kanygin
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  9. Matsumura Akira
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  10. S. Yu. Taskaev
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Corresponding author

Correspondence to P. A. Khaptakhanova.

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Translated by Z. Svitanko

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Uspenskii, S.A., Khaptakhanova, P.A., Zaboronok, A.A. et al. Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy. Dokl Chem 491, 45–48 (2020). https://doi.org/10.1134/S0012500820030027

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  • DOI: https://doi.org/10.1134/S0012500820030027

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