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A Lindqvist-type [W6O19]2‒ organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

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Abstract

In this paper, a new organic–inorganic hybrid compound [Co(L)2]2[W6O19](1) (HL = 2-acetylpyridine thiosemicarbazone) was prepared and characterized. The compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration (MIC) against Staphylococcus aureus (S. aureus, 0.06 µg·mL−1) and Escherichia coli (E. coli, 0.24 µg·mL−1), respectively. Furthermore, the potential mechanism of compound 1 was studied in detail. The potential causes of bacteria death were cell wall/membrane disruption, inhibition of intracellular respiratory chain dehydrogenases (RCD) activity, destruction of reactive oxygen species (ROS) and depletion of glutathione (GSH).

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Grant No. 21671055), Henan University First-class Discipline Cultivation Project (Grant No. 2020YLZDYJ06), Medical Interdisciplinary Training Program of Henan University of China (Grant No. CJ1205A0240007) and the Scientific and Technological Project of Henan province (Grant No. 212102310852).

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Authors and Affiliations

  1. Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, School of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China

    Meng Zhao, **-Yu Zhu, Jiang-Nan Chang, Ming-Xue Li, Li-Hua Ma & **ao-Yuan Guo

  2. Agricultural Products’ Quality and Safety Testing Center of Kaifeng, Kaifeng Agriculture and Rural Bureau, Henan, 475004, China

    Meng Zhao & Yan-Zhen Li

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  1. Meng Zhao
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  2. **-Yu Zhu
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  3. Yan-Zhen Li
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Correspondence to Ming-Xue Li.

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Zhao, M., Zhu, XY., Li, YZ. et al. A Lindqvist-type [W6O19]2‒ organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action. Tungsten 4, 121–129 (2022). https://doi.org/10.1007/s42864-021-00073-x

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