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Utility of the Compensatory Tracking Task for Objective Differentiation of Hypersomnolence in Depression: A High-Density EEG Investigation

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Abstract

Hypersomnolence is a common and debilitating symptom in mood disorders. However, objective differentiation of excessive daytime sleepiness (EDS) from non-EDS in depression has not yet been achieved. This study compared performance on the Compensatory Tracking Task (CTT) and concurrently recorded high-density (hd)EEG theta power in 22 patients with major depressive disorder (MDD) and co-occurring EDS against 22 age- and sex-matched patients with MDD but no EDS, as well as 22 age- and sex-matched healthy controls. Though depressed hypersomnolent participants endorsed feeling sleepier than depressed non-hypersomnolent and healthy control participants prior to starting the CTT, no group differences in CTT performance were observed. Average hdEEG theta power was higher during periods of high error on the CTT compared to periods of low error, but did not differ between the groups. Though the CTT still holds promise as an objective neurobehavioral measure, these results do not indicate a capability to differentiate EDS from non-EDS in mood disorders.

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Funding

This study was funded by the National Institutes of Health (K23MH099234). It was also supported by grants from the American Sleep Medicine Foundation (76-JF-12) and Brain and Behavior Research Foundation (19193).

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, 6001 Research Park Blvd., Madison, WI, 53719, USA

    Emily C. Forscher, Michael L. Prairie, Jesse D. Cook, Sydney L. Notermann & David T. Plante

  2. Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA

    Emily C. Forscher & Jesse D. Cook

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  1. Emily C. Forscher
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Correspondence to Emily C. Forscher.

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Conflict of interest

Emily C. Forscher declares that she/he has no conflict of interest. Michael L. Prairie declares that she/he has no conflict of interest. Jesse D. Cook declares that she/he has no conflict of interest. Sydney L. Notermann declares that she/he has no conflict of interest. David T. Plante has received royalties from Cambridge University Press and has served as a consultant for Teva Pharmaceuticals Australia and Jazz Pharmaceuticals.

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Forscher, E.C., Prairie, M.L., Cook, J.D. et al. Utility of the Compensatory Tracking Task for Objective Differentiation of Hypersomnolence in Depression: A High-Density EEG Investigation. Sleep Vigilance 3, 49–56 (2019). https://doi.org/10.1007/s41782-019-00062-8

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