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Preparation and bioactivity in vitro of hierarchically porous bioactive glass using coral as scaffold

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Abstract

A three-dimensional (3D) hierarchical porous bioactive glass with macropore size of 300–500 μm and mesopore size of 4.6 nm was prepared using coral as scaffold. The bioactivity of the material was investigated by the formation of a hydroxyapatite (HAP) layer on the surface of the material in vitro. The sample can induce the formation of HAP in a very short time (within 4 h) by soaking in simulated body fluid (SBF), and after 12 h soaking, HAP has fully covered the surface of the sample. The flower-like and rod-like nanostructures of HAP can be observed in 4 and 12 h, that is, different morphologies of HAP nanostructures may be obtained by using this simple method. The material not only shows good bioactivity but also retains the mechanical properties of the coral; the novel material may be a promising bioactive material for bone repair.

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Acknowledgements

Financial support for this study was provided by the National Natural Science Foundation of China (21471041, 21171045), Natural Science Foundation of Heilongjiang Province of China ZD201214, and Doctoral Innovation Fund of Harbin Normal University (904/120400386).

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Authors and Affiliations

  1. College of Life Science and Technology, Harbin Normal University, Harbin, 150025, People’s Republic of China

    **aofeng Li, Changhong Guo & Fengyu Qu

  2. College of Chemical and Chemistry, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Fengyu Qu

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  1. **aofeng Li
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  2. Changhong Guo
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Correspondence to Changhong Guo or Fengyu Qu.

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Li, X., Guo, C. & Qu, F. Preparation and bioactivity in vitro of hierarchically porous bioactive glass using coral as scaffold. J Aust Ceram Soc 53, 443–448 (2017). https://doi.org/10.1007/s41779-017-0053-7

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  • DOI: https://doi.org/10.1007/s41779-017-0053-7

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