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Preparation of a Novel Green Fluorescent Carbon Quantum Dots and Application in Fe3+-Specific Detection in Biological System

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Abstract

Trace ferric ion (Fe3+) detection has attracted increasing attention as an essential and indispensable role in many physiological and pathological research. The green-emitting carbon quantum dots (Green-CQDs) were obtained through a green and facile one-step hydrothermal method for the specific recognition and trace detection of Fe3+ in this paper. The optimal excitation and emission wavelengths of the CQDs were 395 nm and 490 nm, respectively. The stokes shift was up to 95 nm, which can effectively reduce the background fluorescence interference. In addition, it also exhibited good water solubility, stability, and high biocompatibility. The fluorescence intensity of Green-CQDs was linearly related to the concentration of Fe3+ (range of 0–80 μmol/L), and the detection limit was as low as 59 nmol/L. These good properties were favorable and successful for Fe3+ detection in tap water, human serum samples and living cells. In addition, a fluorescence visual test paper (FP@CQDs) was prepared utilizing filter paper as carrier, which can quickly identify Fe3+ in real time, and is suitable for the visualization analysis of Fe3+ in environment. As an efficient nanoprobe, the Green-CQDs held great promise and bright prospects in practical application in prevention and early clinical diagnosis of Fe3+-associated diseases.

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Acknowledgements

We appreciatively acknowledge fiscal assistance from Foundation of Shaanxi Provincial Natural Science Basic Research Project, China (2019JQ-461), China Postdoctoral Science Foundation on the 61st Project (2017M613190), and Shaanxi Provincial Education Department (16JK1770).

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  1. **anfen Zhang and Wenxian Wang have contributed equally to this work and should be considered as the co-first authors.

Authors and Affiliations

  1. School of Chemical Engineering, Northwest University, **’an, 710069, China

    **anfen Zhang, Wenxian Wang, Lijiao Guan, Huajie Chen, Dai Li & Saipeng Huang

  2. Chemical Technology Academy of Shandong Province, Qingdao University of Science and Technology, **an, 250014, China

    Lipeng Zhang

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Contributions

XZ: investigation, visualization. WW: conceptualization, data curation, writing—original draft. LG and YZ: resources, validation. DL and HC: visualization, validation. LZ: writing—review and editing. SH: funding acquisition, supervision, writing—review and editing.

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Correspondence to Lipeng Zhang or Saipeng Huang.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Zhang, X., Wang, W., Guan, L. et al. Preparation of a Novel Green Fluorescent Carbon Quantum Dots and Application in Fe3+-Specific Detection in Biological System. J. Anal. Test. 8, 40–51 (2024). https://doi.org/10.1007/s41664-023-00283-x

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