Abstract
Introduction
The clinical diagnosis of the nature of ovarian neoplasm is difficult. Invasive diagnostic techniques are contraindicated in ovarian neoplasm due to fear of tumor spillage and upstaging of the tumor. An intraoperative frozen section (FS) is a valuable diagnostic procedure to diagnose and determine the malignancy in ovarian tumors and thus guides the surgeon in tailoring surgical therapy, particularly in young women.
Aims and Objectives
This study aims to determine the various statistical parameters of frozen section to diagnose ovarian epithelial neoplasm based on tumor behavior and histological subtypes.
Materials and Methods
A retrospective study of intraoperative FS of ovarian neoplasm was conducted over a period of 5 years. The reports of FS and respective formalin-fixed paraffin sections (FFPS) were reviewed. The overall accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined separately for benign, borderline, and malignant epithelial tumors considering FFPS diagnosis as the gold standard.
Results
A total of 341 patients underwent a frozen section for ovarian masses. 68% of them were of epithelial origin. The overall accuracy of the FS to identify malignancy in ovarian neoplasm is 94.6%. The largest discordance in diagnosis was reported in mucinous borderline tumors.
Conclusion
With relevant clinical details, representative tumor sampling, and experience frozen section can be a simple and effective diagnostic tool to guide surgeons to choose the appropriate intraoperative management.
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Apoorva, K., Amirtham, U., Patil, A. et al. Diagnostic Accuracy of Intraoperative Frozen Section in Ovarian Neoplasms: A Tertiary Cancer Center Experience. Indian J Gynecol Oncolog 21, 72 (2023). https://doi.org/10.1007/s40944-023-00740-6
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DOI: https://doi.org/10.1007/s40944-023-00740-6