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Cervix Cancer: Epidemiological, Histological, Diagnostic, Therapeutic, and Prognostic Characteristics in Mohammed VI University Hospital of Marrakech, Morocco

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Indian Journal of Gynecologic Oncology Aims and scope Submit manuscript

Abstract

Background

Cervical cancer is the second leading cause of death among women in develo** countries after breast cancer.

Objectives

To describe epidemiology, management, outcomes, and prognostic factors of cervical cancer in the Radiation-Oncology Department of Mohammed VI University Hospital of Marrakech.

Methods

Retrospective analysis including patient treated for cervical cancer in the Radiation-Oncology Department of Mohammed VI University Hospital of Marrakech between January 2008 to December 2014.

Results

Three hundred and twenty-six cases were included, age ranged between 51 and 60 years. The age of first sexual activity below 18 years was described in 45.1%. In 90.7% of cases, histological analysis showed a squamous cell carcinoma. Stage IIB was the most common (32.6%). Radiotherapy with concurrent chemotherapy was the most widely used therapy, recorded in 78.9% of patients. Tumor size ≤4 cm, adenocarcinoma histological type, absence of lymph node involvement, age less than 50 years, and localized stage were associated with improved 3-year relapse-free survival.

Conclusions

Cervical cancer is a major public health problem in Morocco. Diagnosis is often made at locally advanced stages.

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Abbreviations

HPV:

Human papilloma virus

CRC:

Concomitant radio-chemotherapy

SCC:

Squamous cell carcinoma

ADK:

Adenocarcinoma

ACEH:

Adeno-colpo-enlarged hysterectomy

MRI:

Magnetic resonance imaging

PET:

Positon emission tomography

References

  1. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.

    Article  CAS  PubMed  Google Scholar 

  2. WHO/ICO Information Center of HPV and Cervical Cancer (HPV Information Center). Human papillomavirus and related cancers in the world. Summary report 2010. http://www.who.int/hpvcentre/en/. Accessed 19 Sept 2011.

  3. Cancer Registry of Rabat. Results of the year 2005; 2009, http://www.fmp-usmba.ac.ma/pdf/Documents/cancer_registry_mor_rabat.pdf. Accessed 06 June 2014.

  4. de González AB, Green J. International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 2007;120:885.

    Article  Google Scholar 

  5. Castellsagué X, Bosch FX, Muñoz N, et al. Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners. N Engl J Med. 2002;346:1105.

    Article  PubMed  Google Scholar 

  6. Anttila T, Saikku P, Koskela P, et al. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. JAMA. 2001;285:47.

    Article  CAS  PubMed  Google Scholar 

  7. Wallin KL, Wiklund F, Luostarinen T, et al. A population-based prospective study of Chlamydia trachomatis infection and cervical carcinoma. Int J Cancer. 2002;101:371.

    Article  CAS  PubMed  Google Scholar 

  8. Hawes SE, Kiviat NB. Are genital infections and inflammation cofactors in the pathogenesis of invasive cervical cancer? J Natl Cancer Inst. 2002;94:1592.

    Article  PubMed  Google Scholar 

  9. Castle PE, Wacholder S, Lorincz AT, et al. A prospective study of high-grade cervical neoplasia risk among human papillomavirus-infected women. J Natl Cancer Inst. 2002;94:1406.

    Article  PubMed  Google Scholar 

  10. International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, et al. Carcinoma of the cervix and tobacco smoking: collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies. Int J Cancer. 2006;118:1481.

    Article  Google Scholar 

  11. Muñoz N, Franceschi S, Bosetti C, et al. Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;359:1093.

    Article  PubMed  Google Scholar 

  12. International Collaboration of Epidemiological Studies of Cervical Cancer. Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies. Int J Cancer. 2006;119:1108.

    Article  Google Scholar 

  13. International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, et al. Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet. 2007;370:1609.

    Article  Google Scholar 

  14. Waggoner SE, Darcy KM, Tian C, Lanciano R. Smoking behavior in women with locally advanced cervical carcinoma: a gynecologic oncology group study. Am J Obstet Gynecol. 2010;202(283):e1.

    Google Scholar 

  15. Singh GK, Miller BA, Hankey BF, Edwards BK. Area socioeconomic variations in US cancer incidence, 1975–1999. Bethesda: National Cancer Institute; 2003.

    Google Scholar 

  16. Recoules-Arche A, et al. Does adenocarcinoma of uterine cervix have a worse prognosis than squamous carcinoma. Gynecol Obstet Fertil. 2004;32(2):116–21.

    Article  CAS  PubMed  Google Scholar 

  17. Balleyguier C, Sala E, Da Cunha T, et al. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur Radiol. 2011;21:1102.

    Article  PubMed  Google Scholar 

  18. Bipat S, Glas AS, van der Velden J, et al. Computed tomography and magnetic resonance imaging in staging of uterine cervical carcinoma: a systematic review. Gynecol Oncol. 2003;91:59.

    Article  PubMed  Google Scholar 

  19. Mortier DG, Stroobants S, et al. Laparoscopic para-aortic lymphadenectomy and positron emission tomography scan as staging procedures in patients with cervical carcinoma stage IB2-IIIB. Int J Gynecol Cancer. 2008;18:723–9.

    Article  CAS  PubMed  Google Scholar 

  20. Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (CCCMAC). Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis. Cochrane Database Syst Rev 2010; CD008285.

  21. Elmajjaoui, et al. Epidemiology and outcome of cervical cancer in national institute of Morocco. BMC Women’s Health. 2016;16:62.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Fyles AW, Pintilie M, Kirkbride P, et al. Prognostic factors in patients with cervix cancer treated by radiation therapy: results of a multiple regression analysis. Radiother Oncol. 1995;35:107–17.

    Article  CAS  PubMed  Google Scholar 

  23. Johnson DW, Cox RS, Billingham G, et al. Survival, prognostic factors, and relapse patterns in uterine cervical carcinoma. Am J Clin Oncol. 1983;6:407–15.

    Article  CAS  PubMed  Google Scholar 

  24. Kapp DS, Fischer D, Gutierrez E, et al. Pretreatment prognostic factors in carcinoma of the uterine cervix: amultivariable analysis of the effect of age, stage, histology and bloodcounts on survival. Int J Radiat Oncol Biol Phys. 1983;9:445–55.

    Article  CAS  PubMed  Google Scholar 

  25. Lanciano RM, Won M, Coia LR, et al. Pretreatment and treatment factors associated with improved outcome in squamous cell carcinoma of the uterine cervix: a final report of the 1973 and 1978 patterns of care studies. Int J Radiat Oncol Biol Phys. 1991;20:667–76.

    Article  CAS  PubMed  Google Scholar 

  26. Meanwell CA, Kelly KA, Wilson S, et al. Young age as a prognostic factor in cervical cancer: analysis of population based data from 10022 cases. Br Med J. 1988;296:386–91.

    Article  CAS  Google Scholar 

  27. Perez CA, Grigsby PW, Nene SM, et al. Effect of tumor size on the prognosis of carcinoma of the uterine cervix treated with irradiation alone. Cancer. 1992;69:2796–806.

    Article  CAS  PubMed  Google Scholar 

  28. Rutledge FN, Mitchell MF, Munsell M, et al. Youth as a prognostic factor in carcinoma of the cervix: a matched analysis. Gynecol Oncol. 1992;44:123–30.

    Article  CAS  PubMed  Google Scholar 

  29. Sigurdsson K, Hrafnkelsson J, Geirsson G, et al. Screening as a prognostic factor in cervical cancer: analysis of survival and prognostic factors based on Icelandic population data, 1964–1988. Gynecol Oncol. 1991;43:64–70.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Special thanks are due to the Faculty of Medicine and Pharmacy of Marrakech and Cadi Ayyad University of Marrakech.

Funding

Faculty of Medicine and Pharmacy of Marrakech is the source of funding.

Author information

Authors and Affiliations

  1. Radiation-Oncology Department, Mohammed VI University Hospital, Marrakech, Morocco

    Hind Sami, Abdelhamid El Omrani & Mouna Khouchani

  2. Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco

    Hind Sami, Issam Lalya, Abdelhamid El Omrani & Mouna Khouchani

Authors
  1. Hind Sami
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  2. Issam Lalya
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  3. Abdelhamid El Omrani
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  4. Mouna Khouchani
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Contributions

HS performed research, collected the clinical data and analyzed data statistically. IL wrote the manuscript. AE and MK coordinated the research and revised and approved the final manuscript.

Corresponding author

Correspondence to Issam Lalya.

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All authors declare that they have no conflict of interest.

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Sami, H., Lalya, I., El Omrani, A. et al. Cervix Cancer: Epidemiological, Histological, Diagnostic, Therapeutic, and Prognostic Characteristics in Mohammed VI University Hospital of Marrakech, Morocco. Indian J Gynecol Oncolog 15, 44 (2017). https://doi.org/10.1007/s40944-017-0138-9

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  • DOI: https://doi.org/10.1007/s40944-017-0138-9

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