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Ethylene glycol-mediated synthetic route for production of luminescent silicon nanorod as photodynamic therapy agent

乙二醇介导法制备荧光硅纳米棒用作光动力治疗试剂

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Abstract

One-dimensional silicon nanorod (SiNR) has attracted considerable interest because of its unique morphology and electronic-optical properties that render SiNRs suitable for a broad spectrum of applications, such as fieldeffect transistor, drug carrier, solar cell, nanomechanical device, and lithium-ion battery. However, studies aiming to identify a new synthetic method and apply SiNR in the biomedical field remain limited. This study is the first to use an ethylene glycol-mediated synthetic route to prepare SiNR as a multicolor fluorescent probe and a new photodynamic therapy (PDT) agent. The as-prepared SiNR demonstrates bright fluorescence, excellent storage and photostability, favorable biocompatibility, excitation-dependent emission, and measurable quantity of 1O2 (0.24). On the basis of these features, we demonstrate through in vitro studies that the SiNR can be utilized as a new nanophotosensitizer for fluorescence imaging- guided cancer treatment. Our work leads to a new production process for SiNRs that can be used not only as PDT agents for therapy of shallow tissue cancer but also as excellent, environment-friendly, and red light-induced photocatalysts for the degradation of persistent organic pollutants in the future.

摘要

由于独特的形貌和光电性质, 一维硅纳米棒已被广泛应用于场效应晶体管、 药物载体、 太阳能电池、 纳米机械设备以及锂电池等领域. 然而, 开辟新型荧光硅纳米棒的制备方法并拓展其在生物医学研究中的应用是目前仍迫切需要探索的重要课题. 本文首次基于乙二醇介导法合成了具有良好光稳定性、 生物相容性、 **激发依赖的荧光和可测量的单线态氧量子产率(0.24)等优良特性的硅纳米棒. 这类新型硅纳米棒光敏剂在细胞水**同时实现了荧光成像和光动力学治疗, 表明其在光动力学治疗表层肿瘤领域具有一定应用前景.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (51472252 and 51572269) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB17030400).

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Authors and Affiliations

  1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Bei**g, 100190, China

    Qingyan Jia  (贾庆岩), Weimin Liu  (刘卫敏), Hongyan Zhang  (张洪艳), Jiechao Ge  (葛介超) & Pengfei Wang  (汪鹏飞)

  2. School of Future Technology, University of Chinese Academy of Sciences, Bei**g, 100049, China

    Qingyan Jia  (贾庆岩), Weimin Liu  (刘卫敏), Jiechao Ge  (葛介超) & Pengfei Wang  (汪鹏飞)

  3. College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, China

    Mingxing Chen  (陈明星) & Qingyun Liu  (刘青云)

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  1. Qingyan Jia  (贾庆岩)
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  2. Mingxing Chen  (陈明星)
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  4. Weimin Liu  (刘卫敏)
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  5. Hongyan Zhang  (张洪艳)
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  6. Jiechao Ge  (葛介超)
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  7. Pengfei Wang  (汪鹏飞)
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Corresponding authors

Correspondence to Qingyun Liu  (刘青云) or Jiechao Ge  (葛介超).

Additional information

Qingyan Jia is now a PhD candidate at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences. His current research is focused on the preparation of nanomaterials for phototherapy of cancer.

Jiechao Ge is currently a full professor at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences. His research interests mainly concentrate on the synthesis of nanomaterials and their applications in phototheranostics and photocatalysts.

Qingyun Liu is currently a full professor at the College of Chemical and Environmental Engineering, Shandong University of Science and Technology. Her research interests mainly focus on the preparation of porphyrin/phthyanainorganic nanocomposites and their application in photocatalysts.

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Jia, Q., Chen, M., Liu, Q. et al. Ethylene glycol-mediated synthetic route for production of luminescent silicon nanorod as photodynamic therapy agent. Sci. China Mater. 60, 881–891 (2017). https://doi.org/10.1007/s40843-017-9101-5

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