Abstract
Vanadium (20th in natural abundance) is omnipresent in the environment both naturally and in problematic or toxic concentrations, as pollutant. Ingested, e.g. with drinking water and food, or by inhalation in the form of oxides attached to dust particle, vanadium can cause health hazards. Since vanadate is a phosphate antagonist, vanadium—in appropriate low concentrations—is also expected to exert a variety of physiological actions, some of which have been documented in pre-medicinal or—in the case of diabetes type 2—in phase IIa clinical tests. Other potential implementations, elucidated and scrutinized in this report, include myocardial infarctions, viral, bacterial and parasitic infections (the latter essentially in tropical countries), and cancer.
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Carpentier W, Sandra K, De Smet I, Brige A, De Smet L, Van Beeumen J (2003) Appl Environ Microbiol 69:3636–3639
Hu J, **a W, Pan X, Zheng T, Zhang B, Zhou A et al (2017) Lancet Planet Health 1:230–241
Levina A, Lay PA (2017) Chem Asian J 12:1692–1699
Rehder D (2015) Metallomics 7:730–742
Rehder D (2016) Future Med Chem 8:325–338
Costa-Pessoa J, Etcheverry S, Gambino D (2015) Coord Chem Rev 301–302:24–48
Costa-Pessoa J, Garribba E, Santos MFA, Santos-Silva T (2015) Coord Chem Rev 301–302:49–86
Thomson KH. Lichter J, LeBel C, Scaife MC, Orvig O (2009) J Inorg Biochem 103:554–558
Niu X, **ao R, Wang N, Wang Z, Zhang Y, Quia Q, Yang X (2016) Curr Top Med Chem 16:811–822
Sanna D, Sera M, Micera G, Garribba E (2015) Inorg Chem 54:7753–7766
Sanna D, Sera M, Micera G, Garribba E (2014) Inorg Chim Acta 420:75–84
Rees JA, Bjornsson R, Schlesier J, Sippel D, Einsle O, DeBeer S (2015) Angew Chem Int Ed 54:13249–13252
Sippel D, Einsle O (2017) Nat Chem Biol 13:956–960
Lee CC, Fay AW, Weng T-C, Krest CM, Hedmann B, Hodgson KO, Hu Y, Ribbe MW (2015) Proc Nat Acad Sci 112:13845–13849
Wever R, van der Horst MA (2013) Dalton Trans 42:11778–11786
Rehder D (2015) Metallomics 7:30–742
Xu X, **a S, Zhou L, Zhang Z, Rittmann BE (2015) J Environ Sci 30:122–128
Ścibior A (2016) Chem Biol Interact 258:214–233
Irving E, Stoker AW (2017) Molecules 22:2269
Lindquist Y, Schneider G, Vihko P (1994) Eur J Biochem 221:139–142
Brandão TAS, Hengge AC, Johnson SJ (2010) J Biol Chem 285:15874–15883
Smith DM, Pickering RM, Lewis GT (2008) Q J Med 1012:351–358
Hiromura M, Sakurai H (2008) Metallomics 5:1615–1621
He RJ, Yu ZH, Zhang RY (2014) Acta Pharmacol Sin 35:1227–1246
Köpf-Maier P, Köpf H (1986) Drugs Future 11:297–319
Fichtner I, Claffey J, Deally A, Gleeson B, Hogan M, Markelova RM, Müller-Bunz H, Weber H, Tacke M (2010) J Organomet Chem 695:1175–1181
Liao X, Lu J, Ying P, Zhao P, Bai Y, Li W, Liu M (2013) J Biol Inorg Chem 18:975–984
Sanna D, Ugone V, Micera M, Buglyó P, Biró L, Garribba E (2017) Dalton Trans 46:8950–8967
Lavina A, Lay PA (2017) Chem Asian J 12:1692–1699
Naso LG, Ferrer EG, Butenko N, Cavaco I, Lezama L, Rojo T, Etcheverry SB, Williams PAM (2014) (2011) J Biol Inorg Chem 16:653–668
Evangelou AM (2002) Crit Rev Oncol Hematol 42:249–265
Barford D (2004) Curr Opin Struct Biol 14:679–686
Maurya MR, Haldar C, Khan AA, Azam A, Saluhuddin A, Kumar A, Costa Pessoa J (2012) Eur J Inorg Chem 2012:2560–2577
Benítez J, Guggeri L, Tomaz I, Arrambide G, Navarro M, Costa Pessoa J, Garat B, Gambino D (2009) J Inorg Biochem 103:609–616
Fernández M, Becco L, Correia I, Benítez J, Piro OE, Echeverria OE,GA, Medeiros GA, Comini A, Lavaggi M, Gonzáles ML, Cerecetto M, Moreno H, Costa Pessoa V, Garat J, Gambino B D (2013) J Inorg Biochem 127:150–160
Adriazola IO, do Amaral AE, Amorim JC, Correia BL, Petkowicz CLO, Ramalho Mercê AL, Noleto GR (2014) J Inorg Biochem 132:45–51
Correia I, Adão P, Roy S, Wahba M, Matos C, Maurya MR, Marques F, Pavan FR, Leite CQF, Avecilla F, Coata Pessoa J (2014) J Inorg Biochem 141:83–93
Rosset A, Soares DC, Covelli D, Pannecouque C, Budd L, Collins A, Robertson N, Parsons S, De Clerq E, Kannepohl O, Sadlet PJ (2010) Inorg Chem 49:1122–1132
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Rehder, D. Vanadium in health issues. ChemTexts 4, 20 (2018). https://doi.org/10.1007/s40828-018-0074-z
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DOI: https://doi.org/10.1007/s40828-018-0074-z