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Fluid Mechanics as a Driver of Tissue-Scale Mechanical Signaling in Organogenesis

  • Tissue Engineering and Regenerative Medicine: Organogenesis (Bryan Brown and Christopher L. Dearth, Section Editors)
  • Published:
Current Pathobiology Reports

Abstract

Purpose of Review

Organogenesis is the process during development by which cells self-assemble into complex, multi-scale tissues. While significant focus and research effort have demonstrated the importance of solid mechanics in organogenesis, less attention has been given to the fluid forces that provide mechanical cues over tissue length scales.

Recent Findings

Fluid motion and pressure are capable of creating spatial gradients of forces acting on cells, thus eliciting distinct and localized signaling patterns essential for proper organ formation. Understanding the multi-scale nature of the mechanics is critically important to decipher how mechanical signals sculpt develo** organs.

Summary

This review outlines various mechanisms by which tissues generate, regulate, and sense fluid forces and highlights the impact of these forces and mechanisms in case studies of normal and pathological development.

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Acknowledgments

This work was supported in part by Grants from the National Science Foundation (1537256), the University of Delaware Research Foundation (15A00870), the Delaware COBRE program from the National Institutes of Health (5P30GM110758-02), the Ralph E. Powe Junior Faculty Enhancement Award (J. P. G.) from the Oak Ridge Associated Universities, and the Basil O’Connor Starter Scholar Award (J. P. G.) from the March of Dimes Foundation (5-FY16-33).

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  1. Department of Biomedical Engineering, University of Delaware, 161 Colburn Lab, Newark, DE, 19716, USA

    Rachel M. Gilbert, Joshua T. Morgan, Elizabeth S. Marcin & Jason P. Gleghorn

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  1. Rachel M. Gilbert
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  2. Joshua T. Morgan
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  3. Elizabeth S. Marcin
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  4. Jason P. Gleghorn
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Correspondence to Jason P. Gleghorn.

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Rachel Gilbert, Joshua Morgan, Elizabeth Marcin, and Jason Gleghorn declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Tissue Engineering and Regenerative Medicine: Organogenesis.

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Gilbert, R.M., Morgan, J.T., Marcin, E.S. et al. Fluid Mechanics as a Driver of Tissue-Scale Mechanical Signaling in Organogenesis. Curr Pathobiol Rep 4, 199–208 (2016). https://doi.org/10.1007/s40139-016-0117-3

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  • DOI: https://doi.org/10.1007/s40139-016-0117-3

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