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Organocatalyzed one-pot three-component synthesis of novel 2-((2-hydroxy-1H-indol-3-yl)(phenyl)methyl)-2,3-dihydrophthalazine-1,4-diones

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Abstract

A new, simple and efficient one-pot three-component synthesis of oxindole derivatives has been developed by the reaction of phthalhydrazide, aldehydes and indoline-2-one under reflux conditions. This protocol avoids the use of expensive catalysts, toxic solvents and chromatographic techniques. Excellent yields, shorter reaction time, readily available starting materials and mild reaction condition are the advantages of this method. All synthesized compounds were characterized by 1H NMR, 13C NMR and mass spectroscopy.

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Fig. 1
Scheme 1
Scheme 2

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Acknowledgements

V. Tamilselvi gratefully thank UGC-RGNF, New Delhi, India (F1-17.1/2017-18/RGNF-2017-18-SC-TAM-45541), for financial assistance.

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Authors and Affiliations

  1. Department of Chemistry, Periyar University, Salem, Tamil Nadu, 636011, India

    Velmurugan Tamilselvi, Cinnathambi Subramani Maheswari & Appaswami Lalitha

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  1. Velmurugan Tamilselvi
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  2. Cinnathambi Subramani Maheswari
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  3. Appaswami Lalitha
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Correspondence to Appaswami Lalitha.

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Tamilselvi, V., Maheswari, C.S. & Lalitha, A. Organocatalyzed one-pot three-component synthesis of novel 2-((2-hydroxy-1H-indol-3-yl)(phenyl)methyl)-2,3-dihydrophthalazine-1,4-diones. J IRAN CHEM SOC 19, 609–618 (2022). https://doi.org/10.1007/s13738-021-02326-5

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  • DOI: https://doi.org/10.1007/s13738-021-02326-5

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