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Use of Stem Cells in Wound Healing

  • Wound Care and Healing (H Lev-Tov, Section Editor)
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Abstract

Purpose of Review

This review provides an overview of the principal stages of wound healing, the populations of endogenous and therapeutic stem cells, applications of stem cells in specific types of wounds, and current approaches of stem cell delivery for tissue regeneration.

Recent Findings

New uses of progenitor stem cells have been developed for the treatment of wounds. Stem cells improve wound healing through both local and paracrine effects. Stem cell populations of therapeutic utility include embryonic stem cells, induced pluripotent stem cells, adult bone marrow and adipose-derived mesenchymal stem cells, as well as stem cells from skin, cord blood, and extra fetal tissue. Induced pluripotent stem cells mitigate many of the ethical and immunogenic concerns related to use of embryonically derived stem cells.

Summary

Skin, the largest organ in the human body, serves as a protective barrier for mammals. Both aging and disease contribute to loss of skin barrier function, which can result in consequences such as chronic wounds. Recent advances in many types of stem cell therapy may revolutionize treatment of difficult wounds. Optimal techniques for obtaining and delivering stem cells are still being refined.

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Authors and Affiliations

  1. Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Adam Aronson

  2. Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

    Leah Laageide

  3. Department of Dermatology, University of Iowa Hospitals and Clinics and VA Medical Center, 40022 Pomerantz Family Pavilion, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Jennifer Powers

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Correspondence to Jennifer Powers.

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This article is part of the Topical Collection on Wound Care and Healing

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Aronson, A., Laageide, L. & Powers, J. Use of Stem Cells in Wound Healing. Curr Derm Rep 7, 278–286 (2018). https://doi.org/10.1007/s13671-018-0233-x

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