Abstract
Purpose of the Review
The aim of this article is to describe the literature on the rationale, methods, and outcomes of screening programs for obstructive sleep apnea (OSA).
Recent Findings
The evidence does not support screening for OSA in the general population. Instead, targeted case finding is advised among the following high-risk groups: patients with obesity, congestive heart failure, atrial fibrillation, treatment refractory hypertension, type 2 diabetes, stroke, nocturnal dysrhythmias, and pulmonary hypertension. However, the method of screening remains unclear with some studies suggesting the use of questionnaires to identify risk for OSA prior to polysomnography (PSG), while others recommend 2-step screening involving questionnaires and portable monitors. Commercial motor vehicle (CMV) drivers should undergo universal screening.
Summary
There is a clear rationale for screening, and target populations for screening have been identified. However, the method of screening is not yet clear. Randomized trials should be done to compare the outcomes of screening versus no screening for OSA among the high-risk populations.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Public Health England. Criteria for appraising the viability, effectiveness and appropriateness of a screening programme. 2015. Available online: https://www.gov.uk/government/publications/evidence-review-criteria-national-screening-programmes/criteria-for-appraising-the-viability-effectiveness-and-appropriateness-of-a-screening-programme
Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006–14. doi:10.1093/aje/kws342.
Young T, Palta M, Dempsey J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ. 2009;108(5):246–9.
Coughlin SR, Mawdsley L, Mugarza JA, Calverley PMA, Wilding JPH. Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J. 2004;25:735–41.
Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. JAMA. 2000;283:1829–36.
Young T, Peppard P, Palta M, Hla KM, Finn L, Morgan B, et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med. 1997;157:1746–52.
Peker Y, Carlson J, Hedner J. Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up. Eur Respir J. 2006;28:596–602. doi:10.1183/09031936.06.00107805.
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.
Kylintireas I, Craig S, Nethononda R, Kohler M, Francis J, Choudhury R, et al. Atherosclerosis and arterial stiffness in obstructive sleep apnea—A cardiovascular magnetic resonance study. Atherosclerosis. 2012;222:483–9. doi:10.1056/NEJMoa043104.
Doonan RJ, Scheffler P, Lalli M, Kimoff RJ, Petridou ET, Daskalopoulos ME, et al. Increased arterial stiffness in obstructive sleep apnea: a systematic review. Hypertens Res. 2011;34:23–32.
Hoffstein V, Mateika S. Cardiac-arrhythmias, snoring, and sleep-apnea. Chest. 1994;106:466–71.
Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, et al. Association of nocturnal arrhythmias with sleepdisordered breathing: The Sleep Heart Health Study. Am J Respir Crit Care Med. 2006;173:910–6. doi:10.1164/rccm.200509-1442OC.
Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure the sleep heart health study. Circulation. 2010;122:352–60. doi:10.1161/CIRCULATIONAHA.109.901801.
Chung F, Elsaid H. Screening for obstructive sleep apnea before surgery: why is it important? Curr Opi Anesthesiol. 2009;22:405–11. doi:10.1097/ACO.0b013e32832a96e2.
Liao P, Yegneswaran B, Vairavanathan S, Ziberman P, Chung F, et al. Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study. Canadian J Anaesth. 2009;56:819–28. doi:10.1007/s12630-009-9190-y.
Ravesloot MJL, van Maanen JP, Hilgevoord AAJ, Van Wagensveld BA, de Vries N. Obstructive sleep apnea is underrecognized and underdiagnosed in patients undergoing bariatric surgery. Eur Arch Otorhinolaryngol. 2012;269:1865–71. doi:10.1007/s00405-012-1948-0.
Balk EM, Moorthy D, Obadan NO, et al. Diagnosis and treatment of obstructive sleep apnea in adults [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Jul. (Comparative Effectiveness Reviews, No. 32.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK63560/
Screening for obstructive sleep apnea in adults: an evidence review for the U.S. Preventive Services Task Force AHRQ Publication No. 14–05216-EF-1 June 2016
Horstmann S, Hess CW, Bassetti C, et al. Sleepiness-related accidents in sleep apnea patients. Sleep. 2000;23(3):383–9.
Quan SF, Wright R, Baldwin CM, et al. Obstructive sleep apnea-hypopnea and neurocognitive functioning in the sleep heart health study. Sleep Med. 2006;6:498–507.
Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165(9):1217–39.
Victor LD. Obstructive sleep apnea. Am Fam Physician. 1999;60:2279–86.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5. doi:10.1056/NEJM199304293281704.
Kushida CA, Littner MR, Hirshkowitz M, Morgenthaler TI, Alessi CA, Bailey D, Boehlecke B, et al. Practice parameters for the use of continuous and bilevel positive airway pressure devices to treat adult patients with sleep-related breathing disorders. Sleep. 2006;29:375–80.
Montesi SB, Edwards BA, Malhotra A, Bakker JP. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. JClin Sleep Med. 2012;8(5):587–96. doi:10.5664/jcsm.2170.
Chen L, Pei J-H, Chen H-M. Effects of continuous positive airway pressure treatment on glycaemic control and insulin sensitivity in patients with obstructive sleep apnoea and type 2 diabetes: a meta-analysis. Arch Med Sci. 2014;10(4):637–42. doi:10.5114/aoms.2014.44854.
Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365:1046–53. doi:10.1016/S0140-6736(05)71141-7.
Ellen RL, Marshall SC, Palayew M, Molnar FJ, Wilson KG, Man-Son-Hing M. Systematic review of motor vehicle crash risk in persons with sleep apnea. J Clin Sleep Med. 2006;2:193–200.
Tanaka S, Shima M. Assessment of screening tests for sleep apnea syndrome in the workplace. J Occup Health. 2010;52:99–105.
Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14:540–3.
Morales CR, Hurley S, Wick LC, Staley B, Pack FM, Gooneratne NS, et al. In-home, self-assembled sleep studies are useful in diagnosing sleep apnea in the elderly. Sleep. 2012;35:1491–501. doi:10.5665/sleep.2196.
Abrishami A, Khajehdehi A, Chung F. A systematic review of screening questionnaires for obstructive sleep apnea. Can J Anaesth. 2010;57:423–38. doi:10.1007/s12630-010-9280-x.
Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, et al. Validation of the Berlin questionnaire and American Society of Anesthesiologists checklist as screening tools for obstructive sleep apnea in surgical patients. Anesthesiology. 2008;108:822–30. doi:10.1097/ALN.0b013e31816d91b5.
Silva GE, Vana KD, Goodwin JL, Sherrill DL, Quan SF. Identification of patients with sleep disordered breathing: comparing the four-variable screening tool, STOP, STOP-Bang, and Epworth Sleepiness Scales. J Clin Sleep Med. 2011;7:467–72. doi:10.5664/JCSM.1308.
•• Hrubos-Strom H, Randby A, Namtvedt SK, et al. A Norwegian population-based study on the risk and prevalence of obstructive sleep apnea. The Akershus Sleep Apnea Project (ASAP). J Sleep Res. 2011;201:162–70. doi:10.1111/j.1365-2869.2010.00861.x. The conclusion of this study is that the screening properties of the Berlin Questionnaire are suboptimal in a large sample of randomly selected respondents from the general Norwegian population
• Burgess KR, Havryk A, Newton S, Tsai WH, Whitelaw WA. Targeted case finding for OSA within the primary care setting. J Clin Sleep Med. 2013;9(7):681–6. doi:10.5664/jcsm.2838. In this community screening of 1157 individuals, high-risk patients that may be targeted for screening for OSA are those with BMI > 30, type 2 diabetes, treated hypertension, and ischemic heart disease because of the high prevalence of OSA in this population
Gurubhagavatula I, Fields BG, Morales CR, et al. Screening for severe obstructive sleep apnea syndrome in hypertensive outpatients. J Clin Hypertens (Greenwich). 2013;15(4):279–88. doi:10.1111/jch.12073.
Westlake K, Plihalova A, Pretl M, Lattova Z, Polak J. Screening for obstructive sleep apnea syndrome in patients with type 2 diabetes mellitus: a prospective study on sensitivity of Berlin and STOP-Bang questionnaires. Sleep Med. 2016;26:71–6. doi:10.1016/j.sleep.2016.07.009.
Berger M, Varvarigou V, Rielly A, Czeisler CA, Malhotra A, Kales SN. Employer-mandated sleep apnea screening and diagnosis in commercial drivers. J Occup Environ Med. 2012;54:1017–25. doi:10.1097/JOM.0b013e3182572e16.
• Platt AB, Wick LC, Hurley S, Soto-Calderon H, Wieland W, Staley B, Masilin G, et al. Hits and misses: screening commercial drivers for obstructive sleep apnea using guidelines recommended by a joint task force. JOEM. 2013;55(9):1035–40. doi:10.1097/JOM.0b013e318298fb0e. This study showed that the high burden of OSA combined with the good performance of the screening tools supports universal screening of all commercial drivers
Hoffman B, Wingenbach DD, Kagey AN, Schaneman JL, Kasper D. The long-term health plan and disability cost benefit of obstructive sleep apnea treatment in a commercial motor vehicle driver population. J Occup Environ Med. 2010;52:473–7. doi:10.1097/JOM.0b013e3181dbc8ab.
Bahammam A, Delaive K, Ronald J, Manfreda J, Roos L, Kryger MH. Health care utilization in males with obstructive sleep apnea syndrome two years after diagnosis and treatment. Sleep. 1999;22:740–7.
Kuna ST, Gurubhagavatula I, Maislin G, et al. Noninferiority of functional outcome in ambulatory management of obstructive sleep apnea. Am J Respir Crit Care Med. 2011;183:1238–44. doi:10.1164/rccm.201011-1770OC.
Cawley MJ, Warning 2nd WJ. A systematic review of pharmacists performing obstructive sleep apnea screening services. Int J Clin Pharm. 2016;38(4):752–60. doi:10.1007/s11096-016-0319-0.
Mold JW, Quattlebaum C, Schinnerer E, et al. Identification by primary care clinicians of patients with obstructive sleep apnea: a practice-based research network (PBRN) study. J Am Board Fam Med. 2011;2:138–45. doi:10.3122/jabfm.2011.02.100095.
Hayes SM, Murray S, Castriotta RJ, et al. (Mis) perceptions and interactions of sleep specialists and generalists: obstacles to referrals to sleep specialists and the multidisciplinary team management of sleep disorders. J Clin Sleep Med. 2012;8(6):633–42. doi:10.5664/jcsm.2252.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Virginia S. de Los Reyes, Vincent Anthony S. Tang, Cecilia Jimeno and Patricia Marie Lusica declare no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Slee** and Breathing
Rights and permissions
About this article
Cite this article
de Los Reyes, V.S., Jimeno, C.A., Tang, V.A.S. et al. Screening Programs for Obstructive Sleep Apnea. Curr Pulmonol Rep 6, 75–81 (2017). https://doi.org/10.1007/s13665-017-0170-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13665-017-0170-3