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Type 2 diabetes mellitus and TCF7L2 gene rs12255372 G/T polymorphism: a meta-analysis involving 7990 subjects

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Abstract

The transcription factor 7-like 2 (TCF7L2) G/T gene polymorphism, also known as rs12255372, has been linked to increases in risk for type 2 diabetes (T2DM), especially in the European population. However, a clear consensus on the subject is still lacking in analyses of the Chinese population. To explore the relationship between the TCF7L2 gene polymorphism and T2DM in the Chinese population, we conducted a meta-analysis of 7990 subjects from ten studies. Depending on whether heterogeneity was present, we employed either a fixed or random-effects model, respectively, to assess the pooled odds ratio (ORs) and their corresponding 95% confidence interval (95% CI). TCF7L2 rs12255372 G/T gene polymorphism was significantly associated with T2DM in the Chinese population under allelic (OR 1.38, 95% CI 1.20–1.60, p = 8.59 × 10−6), dominant (OR 1.67, 95% CI 1.20–2.32, p = 0.002), heterozygous (OR 1.65, 95% CI 1.18–2.31, p = 0.003), and additive genetic models (OR 1.53, 95% CI 1.13–2.07, p = 0.006). In the Chinese population, TCF7L2 rs12255372 G/T gene polymorphism may correlate with an increased risk of T2DM. T allele of TCF7L2 rs12255372 G/T gene polymorphism might confer a genetic risk for T2DM in the Chinese population.

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Acknowledgements

This work was funded by the National Natural Science Foundation of China (NSFC 81100073 to Dr. Yan-yan Li), Excellent Young and Middle-Aged Teachers Assistance Program of Nan**g Medical University for Dr. Yan-yan Li (2013–2015, JX2161015034), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). We thank all our colleagues working in the Department of Geriatrics, the First Affiliated Hospital of Nan**g Medical University.

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Authors and Affiliations

  1. Department of Geriatrics, First Affiliated Hospital of Nan**g Medical University, No. 300 Guangzhou Road, Nan**g, 210029, China

    Yan-yan Li, **n-xing Yang, Hong-yu Geng & Ge Gong

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  1. Yan-yan Li
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  2. **n-xing Yang
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  3. Hong-yu Geng
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  4. Ge Gong
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Contributions

Conceived and designed the experiments: Yan-yan Li. Performed the experiments: Yan-yan Li, Ge Gong, and Hong-yu Geng. Analyzed the data: Yan-yan Li and **n-xing Yang. Contributed reagents/material/analysis tools: Yan-yan Li.Wrote the manuscript: Yan-yan Li. Reference collection and data management: Yan-yan Li. Statistical analyses and paper writing: Yan-yan Li. Study design: Yan-yan Li.

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Correspondence to Yan-yan Li.

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Li, Yy., Yang, Xx., Geng, Hy. et al. Type 2 diabetes mellitus and TCF7L2 gene rs12255372 G/T polymorphism: a meta-analysis involving 7990 subjects. Int J Diabetes Dev Ctries 38, 55–61 (2018). https://doi.org/10.1007/s13410-017-0560-7

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  • DOI: https://doi.org/10.1007/s13410-017-0560-7

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