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Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer

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Tumor Biology

Abstract

Accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk and disease outcome in a variety of cancers. We have identified cancer risk-associated D-loop SNPs in gastric cancer patients. In this study, we evaluated the predictive value of these SNPs for cancer outcome. Two SNP sites of nucleotides 489C/T and 523–524AC/del were identified for statistically significant prediction of postoperative survival in gastric cancer by univariate analysis with log-rank test. In addition, the mitochondrial DNA haplogroup N (489T) contributed to the good survival of gastric cancer patients compared with the mitochondrial DNA haplogroup M (489C) genotype (relative risk, 1.753; 95 %CI, 1.005–3.060; p = 0.048) by multivariate analysis with COX hazards model. In conclusion, analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of a poor disease outcome.

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Acknowledgments

This work was supported by Key Basic Research Program of Hebei (14967713D).

Conflicts of interest

All authors disclose any financial, consulting, and personal relationships with other people or organizations that could influence their work.

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Authors and Affiliations

  1. Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China

    Cuiju Wang

  2. Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, People’s Republic of China

    Yingnan Wang, Huiying Wang, Ruixing Zhang & Zhanjun Guo

Authors
  1. Cuiju Wang
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  2. Yingnan Wang
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  3. Huiying Wang
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  4. Ruixing Zhang
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  5. Zhanjun Guo
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Corresponding author

Correspondence to Zhanjun Guo.

Additional information

Cuiju Wang and Yingnan Wang contributed equally to this work.

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Wang, C., Wang, Y., Wang, H. et al. Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer. Tumor Biol. 35, 12555–12559 (2014). https://doi.org/10.1007/s13277-014-2575-8

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  • DOI: https://doi.org/10.1007/s13277-014-2575-8

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