Abstract
Phenolic compounds are a group of secondary metabolites produced by plants under stressful conditions. Phenolic compounds play an important role in the prevention and treatment of certain illnesses and are exploited by the food and pharmaceutical industries. Conventional methods are commonly used as models to compare the efficiencies of alternative extraction methods. Among alternative extraction processes, microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE) and ultrasonic-assisted extraction (UAE) are the most studied. These methods produce extracts rich in phenolic compounds using moderate temperatures, short extraction times, and solvents generally recognized as safe. The combination of extraction time and temperature plays a critical role in the stability of the compounds. Solvents of higher polarity enhance the extraction of phenolic compounds. The use of the ethanol–water mixture for MAE, PLE, and UAE is recommended. MAE and UAE involve shorter extraction times than do PLE and SFE. SFE requires a low average temperature (40 °C). MAE produces the highest total phenolic content [227.63 mg GAE/g dry basis (d.b.)], followed by PLE (173.65 mg GAE/g d.b.), UAE (92.99 mg GAE/g d.b.) and SFE (37 mg GAE/g d.b.). Extraction yields and recovery rates of the phenolic compounds can be enhanced by combining and integrating extraction methods.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alara OR, Abdurahman NH (2019) Microwave-assisted extraction of phenolics from Hibiscus sabdariffa calyces: kinetic modelling and process intensification. Ind Crops Prod 137(February):528–535. https://doi.org/10.1016/j.indcrop.2019.05.053
Alara OR, Abdurahman NH, Olalere O (2017) Optimization of microwave-assisted extraction of flavonoids and antioxidants from Vernonia amygdalina leaf using response surface methodology. Food Bioprod Process 107:36–48. https://doi.org/10.1016/j.fbp.2017.10.007
Alara O, Abdurahman N, Ukaegbu C, Azhari N (2018a) Vernonia cinerea leaves as the source of phenolic compounds, antioxidants, and anti-diabetic activity using microwave-assisted extraction technique. Ind Crops Prod 122(June):533–544. https://doi.org/10.1016/j.indcrop.2018.06.034
Alara OR, Abdurahman NH, Abdul Mudalip SK, Olalere OA (2018b) Microwave-assisted extraction of Vernonia amygdalina leaf for optimal recovery of total phenolic content. J Appl Res Med Aromat Plants 10(February):16–24. https://doi.org/10.1016/j.jarmap.2018.04.004
Alara OR, Abdurahman NH, Ukaegbu CI (2018c) Soxhlet extraction of phenolic compounds from Vernonia cinerea leaves and its antioxidant activity. J Appl Res Med Aromat Plants 11(September):12–17. https://doi.org/10.1016/j.jarmap.2018.07.003
Alexandre AMRC, Matias A, Duarte CMM, Bronze MR (2018) High-pressure CO2 assisted extraction as a tool to increase phenolic content of strawberry-tree (Arbutus unedo) extracts. J CO2 Util 27(July):73–80. https://doi.org/10.1016/j.jcou.2018.07.002
Azmir J, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena F, Jahurul MH, Ghafoor K, Norulaini NA, Omar AKM (2013) Techniques for extraction of bioactive compounds from plant materials: a review. J Food Eng 117(4):426–436. https://doi.org/10.1016/j.jfoodeng.2013.01.014
Barbosa AM, Santos KS, Borges GR, Muniz AVCS, Mendonça FMR, Pinheiro MS, Franceschi E, Dariva C, Padilha FF (2019) Separation of antibacterial biocompounds from Hancornia speciosa leaves by a sequential process of pressurized liquid extraction. Sep Purif Technol 222(April):390–395. https://doi.org/10.1016/j.seppur.2019.04.022
Barrales M, Silveira P, Barbosa PDPM, Paulino B, Pastore G, Macedo GA, Martinez J (2018) Recovery of phenolic compounds from citrus by-products using pressurized liquids—an application to orange peel. Food Bioprod Process 112:9–21. https://doi.org/10.1016/j.fbp.2018.08.006
Basanta MF, Rojas AM, Martinefski MR, Tripodi VP, De’Nobili MD, Fissore EN (2018) Cherry (Prunus avium) phenolic compounds for antioxidant preservation at food interfaces. J Food Eng 239(June):15–25. https://doi.org/10.1016/j.jfoodeng.2018.06.028
Bursa D, Barba FJ, Granato D, Galanakis CM (2018) Pressurized hot water extraction (PHWE) for the green recovery of bioactive compounds and steviol glycosides from Stevia rebaudiana Bertoni leaves. Food Chem 254(February):150–157. https://doi.org/10.1016/j.foodchem.2018.01.192
Caldas TW, Mazza KEL, Teles ASC, Mattos GN, Brígida AIS, Conte-Junior CA, Borguini RG, Godoy RLO (2018) Phenolic compounds recovery from grape skin using conventional and non-conventional extraction methods. Ind Crops Prod 111(May 2017):86–91. https://doi.org/10.1016/j.indcrop.2017.10.012
Chan Y, Yusup S, Quitain AT, Ho Y, Uemura Y, Kheang S (2018) Biomass and bioenergy extraction of palm kernel shell derived pyrolysis oil by supercritical carbon dioxide: evaluation and modeling of phenol solubility. Biomass Bioenergy 116(March):106–112. https://doi.org/10.1016/j.biombioe.2018.06.009
Chen C, Wang L, Wang R, Luo X, Li Y (2018) Ultrasound-assisted extraction from defatted oat (Avena sativa L.) bran to simultaneously enhance phenolic compounds and b-glucan contents: compositional and kinetic studies. J Food Eng 222:1–10. https://doi.org/10.1016/j.jfoodeng.2017.11.002
Chen L, Gnanaraj C, Arulselvan P, El-Seedi H, Teng H (2019) A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: based on its activity in the treatment of Type 2 diabetes. Trends Food Sci Technol 85(June 2018):149–162. https://doi.org/10.1016/j.tifs.2018.11.026
Cvejic J, Krstonosic M, Bursac M, Uros M (2017) Polyphenols. In: Galanakis CM (ed) Nutraceutical and functional food components, 1st edn. Academic Press, London, pp 203–258. https://doi.org/10.1016/B978-0-12-805257-0.00007-7
de Aguiar AC, da Fonseca Machado AP, Angolini CF, de Morais DR, Baseggio AM, Eberlin MN, Junior MR, Martínez J (2019) Sequential high-pressure extraction to obtain capsinoids and phenolic compounds from biquinho pepper (Capsicum chinense). J Supercrit Fluids 150:112–121. https://doi.org/10.1016/j.supflu.2019.04.016
De Calle I, Costas-Rodriguez M (2017) Microwaves for greener extraction. In: Pena-Pereira F, Tobiszewski M (eds) The application of green solvents in separation processes, 1st edn. Elsevier, Amsterdam, pp 253–300. https://doi.org/10.1016/B978-0-12-805297-6.00009-7
de Castro MDL, Castillo-Peinado LS (2016) Microwave-assisted extraction of food components. In: Knoerzer K, Juliano P, Smithers G (eds) Innovative food processing technologies: extraction, separation, component modification and process intensification, 1st edn. Woodhead Publishing, Duxford, pp 57–110. https://doi.org/10.1016/B978-0-08-100294-0.00003-1
de la Rosa LA, Moreno-escamilla JO, Rodrigo-garcía J, Alvarez-parrilla E (2019) Phenolic compounds. In: Yahia EM (ed) Postharvest physiology and biochemistry of fruits and vegetables, 1st edn. pp 253–272. https://doi.org/10.1016/B978-0-12-813278-4.00012-9
Đurović S, Nikolić B, Luković N, Jovanović J, Stefanović A, Šekuljica N, Mi** D, Knežević-Jugović Z (2018) The impact of high-power ultrasound and microwave on the phenolic acid pro fi le and antioxidant activity of the extract from yellow soybean seeds. Ind Crops Prod 122(May):223–231. https://doi.org/10.1016/j.indcrop.2018.05.078
Erşan S, Üstündağ Ö, Reinhold C, Schweiggert RM (2018) Subcritical water extraction of phenolic and antioxidant constituents from pistachio (Pistacia vera L.) hulls. Food Chem 253(January):46–54. https://doi.org/10.1016/j.foodchem.2018.01.116
Galanakis CM, Tsatalas P, Charalambous Z, Galanakis IM (2018) Control of microbial growth in bakery products fortified with polyphenols recovered from olive mill wastewater. Environ Technol Innov 10:1–15. https://doi.org/10.1016/j.eti.2018.01.006
Goldsmith CD, Vuong QV, Stathopoulos CE, Roach PD (2017) Scarlett CJ (2018) Ultrasound increases the aqueous extraction of phenolic compounds with high antioxidant activity from olive pomace. LWT Food Sci Technol 89:284–290. https://doi.org/10.1016/j.lwt.2017.10.065
Goltz C, Ávila S, Barbieri JB, Igarashi-mafra L, Mafra MR (2018) Ultrasound-assisted extraction of phenolic compounds from Macela (Achyrolcine satureioides) extracts. Ind Crops Prod 115(December 2017):227–234. https://doi.org/10.1016/j.indcrop.2018.02.013
Guandalini BBV, Rodrigues NP, Marczak LDF (2019) Sequential extraction of phenolics and pectin from mango peel assisted by ultrasound. Food Res Int 119(November 2018):455–461. https://doi.org/10.1016/j.foodres.2018.12.011
Hatami T, Johner JCF, Meireles MAA (2018) Extraction and fractionation of fennel using supercritical fluid extraction assisted by cold pressing. Ind Crops Prod 123(July):661–666. https://doi.org/10.1016/j.indcrop.2018.07.041
Henrique P, Helena D, Ribeiro B, Amadeu G, Vitali L, Hense H (2019) Extraction of bioactive compounds from feijoa (Acca sellowiana (O. Berg) Burret) peel by low and high-pressure techniques. J Supercrit Fluids 145(December 2018):219–227. https://doi.org/10.1016/j.supflu.2018.12.016
Huerta RR, Saldaña MDA (2018) Pressurized fluid treatment of barley and canola straws to obtain carbohydrates and phenolics. J Supercrit Fluids 141(November 2017):12–20. https://doi.org/10.1016/j.supflu.2017.11.029
Irakli M, Chatzopoulou P, Ekateriniadou L (2018) Optimization of ultrasound-assisted extraction of phenolic compounds: oleuropein, phenolic acids, phenolic alcohols and flavonoids from olive leaves and evaluation of its antioxidant activities. Ind Crops Prod 124(June):382–388. https://doi.org/10.1016/j.indcrop.2018.07.070
Ismail BB, Guo M, Pu Y, Wang W, Ye X, Liu D (2019) Valorisation of baobab (Adansonia digitata) seeds by ultrasound assisted extraction of polyphenolics. Optimisation and comparison with conventional methods. Ultrason Sonochem 52(October 2018):257–267. https://doi.org/10.1016/j.ultsonch.2018.11.023
Ji Y, Hou Y, Ren S, Yao C, Wu W (2018) Highly efficient extraction of phenolic compounds from oil mixtures by trimethylamine-based dicationic ionic liquids via forming deep eutectic solvents. Fuel Process Technol 171(September 2017):183–191. https://doi.org/10.1016/j.fuproc.2017.11.015
Kaderides K, Papaoikonomou L, Serafim M, Goula AM (2019) Microwave-assisted extraction of phenolics from pomegranate peels: optimization, kinetics, and comparison with ultrasounds extraction. Chem Eng Process Process Intensif 137(January):1–11. https://doi.org/10.1016/j.cep.2019.01.006
Lee H, Sivagnanam P, Cho Y, Haq M (2018) Extraction of bioactive compounds from oyster (Crassostrea gigas) by pressurized hot water extraction. J Supercrit Fluids 141(January):120–127. https://doi.org/10.1016/j.supflu.2018.01.008
Liu J, Ji F, Chen F, Guo W, Yang M, Huang S, Zhang F, Liu Y (2018a) Determination of garlic phenolic compounds using supercritical fluid extraction coupled to supercritical fluid chromatography / tandem mass spectrometry. J Pharm Biomed Anal 159:513–523. https://doi.org/10.1016/j.jpba.2018.07.020
Liu J, Lian C, Hu T, Wang C, Xu Y, **ao L (2018b) Two new farnesyl phenolic compounds with anti-in fl ammatory activities from Ganoderma duripora. Food Chem 263(October 2017):155–162. https://doi.org/10.1016/j.foodchem.2018.04.097
Luna-Guevara ML, Luna-Guevara JJ, Hernandez-Carranza P, Ruiz-Espinosa H, Ochoa-Velasco CE (2018) Phenolic compounds: a good choice against chronic degenerative diseases. Stud Nat Prod Chem 59(59):79–108. https://doi.org/10.1016/B978-0-444-64179-3.00003-7
Marić M, Grassino AN, Zhu Z, Barba FJ, Brnčić M, Rimac Brnčić S (2018) An overview of the traditional and innovative approaches for pectin extraction from plant food wastes and by-products: ultrasound-, microwaves-, and enzyme-assisted extraction. Trends Food Sci Technol 76(January):28–37. https://doi.org/10.1016/j.tifs.2018.03.022
Martini S, Conte A, Tagliazucchi D (2018) Bioaccessibility, bioactivity and cell metabolism of dark chocolate phenolic compounds after in vitro gastro-intestinal digestion. J Funct Foods 49(August):424–436. https://doi.org/10.1016/j.jff.2018.09.005
Morerira M, Barroso MF, Boeykens A, Withouck H, Morais S, Delerue-Matos C (2017) Comparison between conventional and microwave-assisted extraction. Ind Crops Prod 104(February):210–220. https://doi.org/10.1016/j.indcrop.2017.04.038
Nabet N, Gilbert-lópez B, Madani K, Herrero M, Ibáñez E, Mendiola JA (2019) Optimization of microwave-assisted extraction recovery of bioactive compounds from Origanum glandulosum and Thymus fontanesii. Ind Crops Prod 129(November 2018):395–404. https://doi.org/10.1016/j.indcrop.2018.12.032
Okiyama DCG, Soares ID, Cuevas MS, Crevelin EJ, Moraes LAB, Melo MP, Oliveira AL, Rodrigues CEC (2018) Pressurized liquid extraction of flavanols and alkaloids from cocoa bean shell using ethanol as solvent. Food Res Int 114(July):20–29. https://doi.org/10.1016/j.foodres.2018.07.055
Oreopoulou V (2003) Extraction of natural antioxidants. In: Tzia C, Liadakis G (eds) Extraction optimization in food engineering. CRC Press, New York, p 18
Osmar G, Bilibio D, Zanella O, Luis A, Paulo J, Carniel N, dos Santos PP, Priamo WL (2018) Pressurized liquid extraction of polyphenols from Goldenberry: Influence on antioxidant activity and chemical composition. Food Bioprod Process 112:63–68. https://doi.org/10.1016/j.fbp.2018.09.001
Otero P, López-martínez MI, García-risco MR (2019) Application of pressurized liquid extraction (PLE) to obtain bioactive fatty acids and phenols from Laminaria ochroleuca collected in Galicia. J Pharm Biomed Anal 164:86–92. https://doi.org/10.1016/j.jpba.2018.09.057
Oussaid S, Madani K, Houali K, Rendueles M, Diaz M (2018) Optimized microwave-assisted extraction of phenolic compounds from Scirpus holoschoenus and its antipseudomonal efficacy, alone or in combination with Thymus fontanesii essential oil. Food Bioprod Process 110:85–95. https://doi.org/10.1016/j.fbp.2018.04.008
Pandey A, Belwal T, Sekar CK, Bhatt ID, Rawal RS (2018) Optimization of ultrasonic-assisted extraction (UAE) of phenolics and antioxidant compounds from rhizomes of Rheum moorcroftianum using response surface methodology (RSM). Ind Crops Prod 119(December 2017):218–225. https://doi.org/10.1016/j.indcrop.2018.04.019
Panja P (2017) Green extraction methods of food polyphenols from vegetable materials. Curr Opin Food Sci 23:173–182. https://doi.org/10.1016/j.cofs.2017.11.012
Papoutsis K, Pristijono P, Golding JB, Stathopoulos CE, Bowyer MC, Scarlett CJ, Vuong QV (2018) Screening the effect of four ultrasound-assisted extraction parameters on hesperidin and phenolic acid content of aqueous citrus pomace extracts. Food Biosci 21(July 2017):20–26. https://doi.org/10.1016/j.fbio.2017.11.001
Pimentel-Moral S, Borrás-linares I, Lozano-sánchez J (2018) Microwave-assisted extraction for Hibiscus sabdariffa bioactive compounds. J Pharm Biomed Anal 156:313–322. https://doi.org/10.1016/j.jpba.2018.04.050
Pimentel-Moral S, Borrás-linares I, Lozano-sánchez J, Arráez-Román D, Martínez-Férez A, Segura-Carretero A (2019) Supercritical CO2 extraction of bioactive compounds from Hibiscus sabdariffa. J Supercrit Fluids 147:213–221. https://doi.org/10.1016/j.supflu.2018.11.005
**ret D, Fabiano-Tixier A-S, Chemat F (2013) Ultrasound-assisted extraction. In: Rostagno MA, Prado JM (eds) Natural product extraction: principles and applications, 1st edn. The Royal Society of Chemistry, Dorchester, pp 89–112
Plaza M, Turner C (2017) Pressurized hot water extraction of bioactives. Compr Anal Chem 76:53–82. https://doi.org/10.1016/bs.coac.2016.12.005
Reder A, Souza CD, Guedes AR, Manoel J, Rodriguez F, Bombardelli MCM, Corazza ML (2018) Extraction of Arctium lappa leaves using supercritical CO2 + ethanol: kinetics, chemical composition, and bioactivity assessments. J Supercrit Fluids 140(April):137–146. https://doi.org/10.1016/j.supflu.2018.06.011
Riciputi Y, Diaz-de-cerio E, Akyol H, Capanoglu E, Cerretani L, Fiorenza M, Verardo V (2018) Establishment of ultrasound-assisted extraction of phenolic compounds from industrial potato by-products using response surface methodology. Food Chem 269(June):258–263. https://doi.org/10.1016/j.foodchem.2018.06.154
Rodsamran P, Sothornvit R (2019) Extraction of phenolic compounds from lime peel waste using ultrasonic-assisted and microwave-assisted extractions. Food Biosci 28(January):66–73. https://doi.org/10.1016/j.fbio.2019.01.017
Roleira FMF, Tavares-da-silva EJ, Varela CL, Costa SC, Silva T, Garrido J, Borges F (2015) Plant derived and dietary phenolic antioxidants: anticancer properties. Food Chem 183:235–258. https://doi.org/10.1016/j.foodchem.2015.03.039
Rosa PT, Parajó JC, Domínguez H, Moure A, Díaz-Reinoso B, Smith RL, Toyomizu M, Florusse LJ, Peters CJ, Goto M, Lucas S, Meireles MAA (2009) Supercritical and pressurized fluid extraction applied to the food industry. In: Meireles MAA (ed) Extracting bioactive compounds for food products, 1st edn. CRC Press, New York, pp 269–288
Roselló-Soto E, Barba FJ, Lorenzo JM, Munekata PES, Gómez B, Moltó JC (2019) Phenolic profile of oils obtained from “ horchata ” by-products assisted by supercritical-CO2 and its relationship with antioxidant and lipid oxidation parameters: triple TOF-LC-MS-MS characterization. Food Chem 274(July 2018):865–871. https://doi.org/10.1016/j.foodchem.2018.09.055
Rutkowska M, Namieśnik J, Konieczka P (2017) Ultrasound-assisted extraction. In: Pena-Pereira F, Tobiszewski M (eds) The application of green solvents in separation processes. Elsevier, Amsterdam, pp 301–324. https://doi.org/10.1016/B978-0-12-805297-6.00010-3
Santos-Zea L, Gutiérrez-Uribe JA, Benedito J (2019) Effect of ultrasound intensification on the supercritical fluid extraction of phytochemicals from Agave salmiana bagasse. J Supercrit Fluids 144(October 2018):98–107. https://doi.org/10.1016/j.supflu.2018.10.013
Setyaningsih W, Saputro IE, Carrera CA, Palma M (2019) Optimisation of an ultrasound-assisted extraction method for the simultaneous determination of phenolics in rice grains. Food Chem 288(October 2018):221–227. https://doi.org/10.1016/j.foodchem.2019.02.107
Sharayei P, Azarpazhooh E, Zomorodi S, Ramaswamy HS (2019) Ultrasound assisted extraction of bioactive compounds from pomegranate (Punica granatum L.) peel. LWT 101(November 2018):342–350. https://doi.org/10.1016/j.lwt.2018.11.031
Socrier L, Quéro A, Verdu M, Song Y, Molinié R (2019) Flax phenolic compounds as inhibitors of lipid oxidation: elucidation of their mechanisms of action. Food Chem 274(August 2018):651–658. https://doi.org/10.1016/j.foodchem.2018.08.126
Sumere BR, de Souza MC, dos Santos MP, Bezerra RMN, da Cunha DT, Martinez J, Rostagno MA (2018) Combining pressurized liquids with ultrasound to improve the extraction of phenolic compounds from pomegranate peel (Punica granatum L.). Ultrason Sonochem 48(April):151–162. https://doi.org/10.1016/j.ultsonch.2018.05.028
Tanase C, Bujor O, Popa VI (2019) Phenolic natural compounds and their influence on physiological processes in plants. Polyphenols in plants, 2nd edn. Elsevier Inc., Amsterdam. https://doi.org/10.1016/B978-0-12-813768-0.00003-7
Tiwari BK (2015) Ultrasound: a clean, green extraction technology. Trends Anal Chem 71:100–109. https://doi.org/10.1016/j.trac.2015.04.013
Tsimogiannis D, Oreopoulou V (2019) Classification of phenolic compounds in plants. In: Watson RR (ed) Polyphenols in plants, 2nd edn. Academic Press, London, pp 263–284. https://doi.org/10.1016/B978-0-12-813768-0.00026-8
Ullah M, Uddin Z, Song YH, Li ZP, Kim JY, Ban YJ, Park KH (2019) Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissima. S Afr J Bot 120:326–330. https://doi.org/10.1016/j.sajb.2018.10.020
Valadez-Carmona L, Ortiz-Moreno A, Ceballos-Reyes G, Mendiola JA, Ibáñez E (2018) Valorization of cacao pod husk through supercritical fluid extraction of phenolic compounds. J Supercrit Fluids 131(June 2017):99–105. https://doi.org/10.1016/j.supflu.2017.09.011
Vitor D, Tarone AG, Betim C, Fernández G, Martínez J (2019) Pressurized liquid extraction of bioactive compounds from grape marc. J Food Eng 240(July 2018):105–113. https://doi.org/10.1016/j.jfoodeng.2018.07.019
Wong-Paz JE, Muñiz-márquez DB, Aguilar-zárate P, Cruz K, Reyes-luna C, Rodríguez R, Aguilar CN (2017) Extraction of bioactive phenolic compounds by alternative technologies. In: Grumezescu AM, Holban AM (eds) Ingredients extraction by physico-chemical methods in food. Elsevier Inc., Amsterdam. https://doi.org/10.1016/B978-0-12-811521-3/00005-3
Yahya NA, Attan N, Wahab RA (2018) An overview of cosmeceutically relevant plant extracts and strategies for extraction of plant-based bioactive compounds. Food Bioprod Process 112:69–85. https://doi.org/10.1016/j.fbp.2018.09.002
Yousefian M, Shakour N, Hosseinzadeh H, Hayes AW (2019) The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine 55(August 2018):200–213. https://doi.org/10.1016/j.phymed.2018.08.002
Yuan B, Lu M, Eskridge KM, Isom LD, Hanna MA (2018a) Extraction, identification, and quantification of antioxidant phenolics from hazelnut (Corylus avellana L.) shells. Food Chem 244(September 2017):7–15. https://doi.org/10.1016/j.foodchem.2017.09.116
Yuan Y, Zhang J, Fan J, Clark J, Shen P, Li Y, Zhang C (2018b) Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase. Food Res Int 113(May):288–297. https://doi.org/10.1016/j.foodres.2018.07.021
Zhou P, Wang X, Liu P, Huang J, Wang C, Pan M (2018) Enhanced phenolic compounds extraction from Morus alba L. leaves by deep eutectic solvents combined with ultrasonic-assisted extraction. Ind Crops Prod 120(May):147–154. https://doi.org/10.1016/j.indcrop.2018.04.071
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Osorio-Tobón, J.F. Recent advances and comparisons of conventional and alternative extraction techniques of phenolic compounds. J Food Sci Technol 57, 4299–4315 (2020). https://doi.org/10.1007/s13197-020-04433-2
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13197-020-04433-2