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Chondroblastoma of Thoracic Vertebrae: a Case Report and Review of the Literature

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Abstract

Chondroblastoma is a rare benign cartilaginous bone tumor typically seen at the epiphysis of long axial bones. In this regard, there are rare findings about spinal chondroblastomas. We report a 29-year-old man with T1 vertebral chondroblastoma misdiagnosed with a traumatic fracture following an accident. The patient was admitted to our clinic with a chief complaint of axial back pain and kyphosis following posterior spinal fixation. We report his clinical and imaging data before his past operation and at this admission. Our patient underwent a two-stage operation. In the first stage, posterior spinal reconstruction and kyphosis correction was performed. In the second stage, mass resection was performed anteriorly in the T1 vertebral body as much as possible. The results confirmed the chondroblastoma diagnosis histologically. Our patient remained symptom-free with no growth in tumor remnant during 6 months follow-up. Although vertebral chondroblastoma is a sporadic tumor, it should be considered in the differential diagnosis when facing a vertebral infiltrative osteolytic mass, even when mimicking a traumatic fracture after the accident. In addition, histological confirmation is necessary under such conditions. We also reviewed the literature’s clinical presentations, imaging findings, and treatments of 34 case reports with vertebral chondroblastoma.

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References

  1. Negri S, Wangsiricharoen S, Chang L, Gross J, Levin AS, Morris CD, McCarthy EF, James AW (2021) Clinicopathologic analysis of chondroblastoma in adults: a single-institution case series. Int J Surg Pathol 29(2):120–128. https://doi.org/10.1177/1066896920927794

    Article  CAS  PubMed  Google Scholar 

  2. Kurth AA, Warzecha J, Rittmeister M, Schmitt E, Hovy L (2000) Recurrent chondroblastoma of the upper thoracic spine. A case report and review of the literature. Arch Orthop Trauma Surg 120(9):544–547. https://doi.org/10.1007/s004029900125

    Article  CAS  PubMed  Google Scholar 

  3. Venkatasamy A, Chenard MP, Massard G, Steib JP, Bierry G (2017) Chondroblastoma of the thoracic spine: a rare location. Case report with radiologic-pathologic correlation. Skeletal Radiol 46(3):367–372. https://doi.org/10.1007/s00256-016-2550-0

    Article  CAS  PubMed  Google Scholar 

  4. Vialle R, Feydy A, Rillardon L, Tohme-Noun C, Anract P, Colombat M, De Pinieux G, Drape JL, Guigui P (2005) Chondroblastoma of the lumbar spine. Report of two cases and review of the literature. J Neurosurg Spine 2(5):596–600. https://doi.org/10.3171/spi.2005.2.5.0596

    Article  PubMed  Google Scholar 

  5. Shakir TM, Li W, Wang H, Niu C, Zhang M (2018) Chondroblastoma Of The Lumbar Vertebra. J Ayub Med Coll Abbottabad 30(4):608–610

    PubMed  Google Scholar 

  6. Tathe SP, Parate SN, Jaiswal KN, Randale AA (2018) Intraoperative crush smear cytology of vertebral chondroblastoma: A diagnostic challenge. Diagnostic cytopathology 46(1):79–82. https://doi.org/10.1002/dc.23799

    Article  PubMed  Google Scholar 

  7. Attar A, Ugur HC, Caglar YS, Erdogan A, Ozdemir N (2001) Chondroblastoma of the thoracic vertebra. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 8(1):59–60. https://doi.org/10.1054/jocn.2000.0780

    Article  CAS  PubMed  Google Scholar 

  8. Bloem JL, Mulder JD (1985) Chondroblastoma: A clinical and radiological study of 104 cases. Skeletal Radiology 14(1):1–9. https://doi.org/10.1007/BF00361187

    Article  CAS  PubMed  Google Scholar 

  9. Kim S, Cho K-J, Park Y, Lee J-S, Kwon H-J, Chung H, Kim M-J (2011) Chondroblastoma of the lumbar spine - a case report and review of the literature. Korean J Pathol 45:532. https://doi.org/10.4132/KoreanJPathol.2011.45.5.532

    Article  Google Scholar 

  10. Nishida J, Kato S, Murakami H, Ehara S, Satoh T, Okada K, Shimamura T (2003) Tetraparesis caused by chondroblastoma of the cervical spine: a case report. Spine (Phila Pa 1976) 28(9):E173–E178. https://doi.org/10.1097/01.BRS.0000058731.83977.61

    Article  PubMed  Google Scholar 

  11. Jia Q, Liu C, Yang J, Ji Y, Wei H, Liu T, Yang X, Yang C, **ao J (2018) Clinical features, treatments and long-term follow-up outcomes of spinal chondroblastoma: report of 13 clinical cases in a single center. J Neuro-Oncol 140(1):99–106. https://doi.org/10.1007/s11060-018-2935-0

    Article  CAS  Google Scholar 

  12. Chen W, DiFrancesco LM (2017) Chondroblastoma: An Update. Arch Pathol Lab Med 141(6):867–871. https://doi.org/10.5858/arpa.2016-0281-RS

    Article  CAS  PubMed  Google Scholar 

  13. Hernández Martínez SJ, Campa Núñez H, Ornelas Cortinas G, Garza Garza R (2011) Chondroblastoma of the fourth lumbar vertebra diagnosed by aspiration biopsy: case report and review of the literature. Acta cytologica 55(5):473–477. https://doi.org/10.1159/000328709

    Article  PubMed  Google Scholar 

  14. Leung LY, Shu SJ, Chan MK, Chan CH (2001) Chondroblastoma of the lumbar vertebra. Skeletal Radiol 30(12):710–713. https://doi.org/10.1007/s002560100432

    Article  CAS  PubMed  Google Scholar 

  15. Howe JW, Baumgard S, Yochum TR, Sladich MA (1988) Case report 449: Chondroblastoma involving C5 and C6. Skeletal Radiol 17(1):52–55. https://doi.org/10.1007/bf00361456

    Article  CAS  PubMed  Google Scholar 

  16. Ilaslan H, Sundaram M, Unni KK (2003) Vertebral chondroblastoma. Skeletal Radiol 32(2):66–71. https://doi.org/10.1007/s00256-002-0599-4

    Article  PubMed  Google Scholar 

  17. Chung OM, Yip SF, Ngan KC, Ng WF (2003) Chondroblastoma of the lumbar spine with cauda equina syndrome. Spinal cord 41(6):359–364. https://doi.org/10.1038/sj.sc.3101458

    Article  CAS  PubMed  Google Scholar 

  18. 김긍년, 윤도흠 (2005) A case of thoracic vertebral chondroblastoma, treated with 3-D image-guided resection and reconstruction. Journal of Korean Neurosurgical Society (대한신경외과학회지) 37(2):154–156.

  19. Osman W, Zaoui A, Abdelkrim SB, Hamida RB, Ayèche MB (2014) Chondroblastoma of the lower thoracic spine. A Case Report and Review of the Literature. 2(4):78–81

    Google Scholar 

  20. Sohn SH, Koh SA, Kim DG, Park SW, Lee KH, Kim MK, Choi JH, Hyun MS (2009) A case of spine origin chondroblastoma metastasis to lung. Cancer Res Treat 41(4):241–244. https://doi.org/10.4143/crt.2009.41.4.241

    Article  PubMed  PubMed Central  Google Scholar 

  21. Mu H, Jiang Y, Xue L, Hua Y, Lin J, Cai Z (2021) H3.3 K36M mutation as a clinical diagnosis method of suspected chondroblastoma cases. Orthopaedic Surgery 13(2):616–622. https://doi.org/10.1111/os.12878

    Article  PubMed  PubMed Central  Google Scholar 

  22. Konishi E, Nakashima Y, Mano M, Tomita Y, Kubo T, Araki N, Morii E, Yoshikawa H, Haga H, Toguchida J, Ueda T, Osawa M, Hoshi M, Inoue T, Aono M, Yanagisawa A (2017) Chondroblastoma of extra-craniofacial bones: Clinicopathological analyses of 103 cases. Pathol Int 67(10):495–502. https://doi.org/10.1111/pin.12586

    Article  PubMed  Google Scholar 

  23. Zheng BW, Niu HQ, Wang XB, Li J (2021) Sacral chondroblastoma - a rare location, a rare pathology: A case report and review of literature. World J Clin Cases 9(20):5709–5716. https://doi.org/10.12998/wjcc.v9.i20.5709

    Article  PubMed  PubMed Central  Google Scholar 

  24. Angelini A, Hassani M, Mavrogenis AF, Trovarelli G, Romagnoli C, Berizzi A, Ruggieri P (2017) Chondroblastoma in adult age. European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie 27(6):843–849. https://doi.org/10.1007/s00590-017-1996-7

    Article  Google Scholar 

  25. Hoeffel JC, Brasse F, Schmitt M, Plenat F, Vignaud JM, Czorny A, Montaut J, Marchal AL (1987) About one case of vertebral chondroblastoma. Pediatr Radiol 17(5):392–396. https://doi.org/10.1007/BF02396616

    Article  CAS  PubMed  Google Scholar 

  26. Buraczewski J, Lysakowska J, Rudowski W (1957) Chondroblastoma (Codman's tumour) of the thoracic spine. J Bone Joint Surg Br 39-B(4):705–710. https://doi.org/10.1302/0301-620X.39B4.705

    Article  CAS  PubMed  Google Scholar 

  27. Sagoo NS, Southern EP, King AG, Stark MW, McBride LA (2020) Missed radiographic and clinical findings in a case of non-idiopathic scoliosis resulting from chondroblastoma. Spine Deform. https://doi.org/10.1007/s43390-020-00185-3

  28. Shin BJ, Yun T-K, Lim K-C, Lee JC, Kim K-J, Kim D-W, Kim Y-I (2001) Chondroblastoma of the first lumbar vertebra - a case report. J Korean Soc Spine Surg 8. https://doi.org/10.4184/jkss.2001.8.1.90

  29. Akai M, Tateishi A, Machinami R, Iwano K, Asao T (1986) Chondroblastoma of the sacrum. A case report. Acta Orthop Scand 57(4):378–381. https://doi.org/10.3109/17453678608994417

    Article  CAS  PubMed  Google Scholar 

  30. Giri P, Chavan V (2017) Chondroblastoma of thoracic vertebra in young adult causing paraparesis. Romanian Neurosurgery 31. https://doi.org/10.1515/romneu-2017-0054

  31. Baumhoer D, Harder D, Ameline B, Dawson H, Kollar A (2020) Metastasizing chondroblastoma: a rare bone tumor no longer supported by the WHO classification. Skeletal Radiol. https://doi.org/10.1007/s00256-020-03525-6

  32. Edel G, Ueda Y, Nakanishi J, Brinker KH, Roessner A, Blasius S, Vestring T, Müller-Miny H, Erlemann R, Wuisman P (1992) Chondroblastoma of bone. A clinical, radiological, light and immunohistochemical study. Virchows Archiv A, Pathological Anatomy and Histopathology 421(4):355–366. https://doi.org/10.1007/bf01660984

    Article  CAS  PubMed  Google Scholar 

  33. Kunze E, Graewe T, Peitsch E (1987) Histology and biology of metastatic chondroblastoma: Report of a case with a review of the literature. Pathol Res Pract 182(1):113–120. https://doi.org/10.1016/S0344-0338(87)80151-6

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Parisa Javadnia.

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Tabibkhooei, A., Javadnia, P. Chondroblastoma of Thoracic Vertebrae: a Case Report and Review of the Literature. Indian J Surg Oncol 15 (Suppl 1), 22–28 (2024). https://doi.org/10.1007/s13193-022-01659-8

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