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The emerging role of circular RNAs in cardiovascular diseases

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Abstract

Cardiovascular disease (CVD) is one of the vital causes of morbidity and mortality, and the number of deaths from CVD has increased worldwide. Circular RNAs (circRNAs) is a novel type of endogenous noncoding RNA, which can form covalent closed continuous rings and are highly expressed in the eukaryotic transcriptome. In recent years, research on circRNAs have been increasing and the researchers have also become cumulatively aware of the association between circRNAs and CVD. This review highlights the biogenesis and functions of circRNAs and the role in cardiovascular diseases.

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Abbreviations

CVD:

Cardiovascular disease

circRNAs:

Circular RNAs

EIciRNAs:

Exon-intron circRNAs

ciRNAs:

Circular intronic RNAs

ciRS-7:

Circular RNA sponge for miR-7

SR:

Serine-arginine

hnRNP:

Heterogeneous nuclear ribonucleoprotein

Pol II:

Polymerase II

snRNPs:

Small nuclear ribonucleoproteins

CDK2:

Cyclin-dependent kinase 2

HUVECs:

Human umbilical vein endothelial cells

cANRIL:

Circular antisense noncoding RNA in the INK4 locus

SNPs:

Single nucleotide polymorphisms

PES1:

Pescadillo homologue 1

TAC:

Thoracic aortic constriction

HRCR:

Heart-related circRNA

IGF-1:

Insulin-like growth factors-1

NRG-1-ICD:

Neuregulin-1 intracellular domain

α-SMA:

Smooth muscle α-actin

EH:

Essential hypertension

TGF:

Transforming growth factor

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Funding

This work was financially supported by Young Elite Scientists Sponsorship Program by CAST (No. CACM-2018-QNRC2-B04) and Young Prominant Medical Professionals Program by Tian**.

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  1. These authors contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. First Teaching Hospital of Tian** University of Traditional Chinese Medicine, Tian**, China

    Yuejia Ding, Chunmiao Lu, Wanqin Zhang, Yuan Wang, Ya** Zhu, Shichao Lv & Jun** Zhang

  2. Tian** Medical University Cancer Institute and Hospital, Tian**, China

    Yanyang Li

  3. Tian** Key Laboratory of Traditional Research of TCM Prescription and Syndrome, Tian**, China

    Shichao Lv

Authors
  1. Yuejia Ding
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  2. Chunmiao Lu
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  3. Wanqin Zhang
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  4. Yuan Wang
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  5. Yanyang Li
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  6. Ya** Zhu
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  7. Shichao Lv
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  8. Jun** Zhang
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Contributions

Yuejia Ding and Chunmiao Lu wrote the paper. Wanqin Zhang, Yuan Wang, and Yanyang Li made the literature selection. Shichao Lv, Ya** Zhu, and Jun** Zhang revised the paper.

The authors declare that all data were generated in-house and that no paper mill was used.

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Correspondence to Shichao Lv or Jun** Zhang.

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Key points

• CircRNAs exhibit important functions in cardiovascular disease.

• The biogenesis of circRNAs can be divided into two ways

• CircRNAs may become therapeutic targets for cardiovascular diseases

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Ding, Y., Lu, C., Zhang, W. et al. The emerging role of circular RNAs in cardiovascular diseases. J Physiol Biochem 77, 343–353 (2021). https://doi.org/10.1007/s13105-021-00807-y

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