SpringerLink
Log in

Detoxification of Trimethoprim Antibiotic Using NiFe2O4@MoO3 Magnetic Nanocomposites Phyto-synthesized with Green Route: Experimental and RSM Modeling

  • Research
  • Published:
BioNanoScience Aims and scope Submit manuscript

Abstract

Pharmaceutical pollutants are among the most important issues in human life. The reason for investigating and controlling environmental pollution is the entry of these pollutants into the food cycle and drug resistance, which causes many environmental risks. In this study, the rate of photocatalytic degradation of TMP, a model organic pollutant, was investigated using NiFe2O4@MoO3 nanocomposites. The characteristics of the nanocomposites were identified using XRD, FESEM, EDX, and VSM techniques. This study aimed to explore the effects of different factors on the photocatalytic removal of the trimethoprim antibiotic (TMP) using a central composite design (CCD) and response surface method (RSM). Significant variables were identified, including initial pH (3–9), catalyst dose (5–100 mg/L), pollutant concentration (20–100 mg/L), and contact time (0–120 min), and 30 experiments were conducted to optimize the process. Statistical analysis based on analysis of variance (ANOVA) showed that the following factors influenced the response. In addition, the results showed that the efficiency of the photocatalytic process increased with an increase in catalyst and residence time, and the efficiency of the photocatalytic process increased with an increase in pH up to 6.3. RSM results revealed the best experimental conditions for TMP degradation under UV light. They showed that the initial pollutant concentration and pH had a greater impact on the degradation process than did the catalyst dose and retention time. This suggests that optimizing operational factors can significantly improve the performance of photocatalytic processes for removing antibiotics such as trimethoprim.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Ezzariai, A., Hafidi, M., Khadra, A., Aemig, Q., El Fels, L., Barret, M., et al. (2018). Human and veterinary antibiotics during composting of sludge or manure: Global perspectives on persistence, degradation, and resistance genes. Journal of hazardous materials., 359, 465–481.

    Article  Google Scholar 

  2. Ahmed, M. B., Zhou, J. L., Ngo, H. H., Guo, W., Thomaidis, N. S., & Xu, J. (2017). Progress in the biological and chemical treatment technologies for emerging contaminant removal from wastewater: A critical review. Journal of hazardous materials., 323, 274–298.

    Article  Google Scholar 

  3. Naghizadeh, A., Momeni, F., & Derakhshani, E. (2017). Efficiency of ultrasonic process in regeneration of graphene nanoparticles saturated with humic acid. Desalination and Water Treatment., 70, 290–293.

    Article  Google Scholar 

  4. Ahmadian, M., Derakhshankhah, H., & Jaymand, M. (2023). Recent advances in adsorption of environmental pollutants using metal–organic frameworks-based hydrogels. International Journal of Biological Macromolecules, 231, 123333. https://doi.org/10.1016/j.ijbiomac.2023.123333.

  5. Naghizadeh, A., Etemadinia, T., Derakhshani, E., & Esmati, M. (2023). Graphitic carbon nitride loaded on powdered mesoporous silica nanoparticles for photocatalytic tetracycline antibiotic degradation under UV-C light irradiation. Research on Chemical Intermediates., 49(3), 1165–1177.

    Article  Google Scholar 

  6. Linghu, K., Wu, Q., Zhang, J., Wang, Z., Zeng, J., & Gao, S. (2023). Occurrence, distribution and ecological risk assessment of antibiotics in Nanming river: Contribution from wastewater treatment plant and implications of urban river syndrome. Process Safety and Environmental Protection., 169, 428–436.

    Article  Google Scholar 

  7. Xu, Z., Jia, Y., Huang, B., Zhao, D., Long, X., Hu, S., et al. (2023). Spatial distribution, pollution characteristics, and health risks of antibiotic resistance genes in China: A review. Environmental Chemistry Letters, 21, 2285–2309.

    Article  Google Scholar 

  8. de Nies, L., Kobras, C. M., & Stracy, M. (2023). Antibiotic-induced collateral damage to the microbiota and associated infections. Nature Reviews Microbiology, 21(12), 789–804.

    Article  Google Scholar 

  9. Das, M. K., Das, S., & Srivastava, P. K. (2023). An overview on the prevalence and potential impact of antimicrobials and antimicrobial resistance in the aquatic environment of India. Environmental Monitoring and Assessment., 195(9), 1015.

    Article  Google Scholar 

  10. Derakhshani, E., & Naghizadeh, A. (2014). Ultrasound regeneration of multi wall carbon nanotubes saturated by humic acid. Desalination and Water Treatment., 52(40–42), 7468–7472.

    Article  Google Scholar 

  11. Sanusi, I. O., Olutona, G. O., Wawata, I. G., & Onohuean, H. (2023). Occurrence, environmental impact and fate of pharmaceuticals in groundwater and surface water: A critical review. Environmental Science and Pollution Research., 30(39), 90595–90614.

    Article  Google Scholar 

  12. Montoya-Hinojosa, E. I., Salazar-Sesatty, H. A., Alvizo-Baez, C. A., Terrazas-Armendariz, L. D., Luna-Cruz, I. E., Alcocer-González, J. M., et al. (2023). Antibiofilm and antimicrobial activity of curcumin-chitosan nanocomplexes and trimethoprim-sulfamethoxazole on Achromobacter, Burkholderia, and Stenotrophomonas isolates. Expert Review of Anti-infective Therapy., 21(2), 213–223.

    Article  Google Scholar 

  13. Mpatani, F. M., Aryee, A. A., Kani, A. N., Han, R., Li, Z., Dovi, E., et al. (2021). A review of treatment techniques applied for selective removal of emerging pollutant-trimethoprim from aqueous systems. Journal of Cleaner Production., 308, 127359.

    Article  Google Scholar 

  14. Dian, S., Ganiem, A. R., & Ekawardhani, S. (2023). Cerebral toxoplasmosis in HIV-infected patients: A review. Pathogens and Global Health., 117(1), 14–23.

    Article  Google Scholar 

  15. de Ilurdoz, M. S., Sadhwani, J. J., & Reboso, J. V. (2022). Antibiotic removal processes from water & wastewater for the protection of the aquatic environment-A review. Journal of water process engineering., 45, 102474.

    Article  Google Scholar 

  16. Luo, S., Zhao, Z.-Y., Liu, Y., Liu, R., Liu, W.-Z., Feng, X.-C., et al. (2023). Recent advancements in antibiotics containing wastewater treatment by integrated bio-electrochemical-constructed wetland systems (BES-CWs). Chemical Engineering Journal., 457, 141133.

    Article  Google Scholar 

  17. Sahay, P., Mohite, D., Arya, S., Dalmia, K., Khan, Z., & Kumar, A. (2023). Removal of the emergent pollutants (hormones and antibiotics) from wastewater using different kinds of biosorbent—A review. Emergent Materials., 6(2), 373–404.

    Article  Google Scholar 

  18. Manna, M., & Sen, S. (2023). Advanced oxidation process: A sustainable technology for treating refractory organic compounds present in industrial wastewater. Environmental Science and Pollution Research., 30(10), 25477–25505.

    Article  Google Scholar 

  19. Reza, K. M., Kurny, A., & Gulshan, F. (2017). Parameters affecting the photocatalytic degradation of dyes using TiO 2: A review. Applied Water Science., 7, 1569–1578.

    Article  Google Scholar 

  20. Constantino, D. S., Dias, M. M., Silva, A. M., Faria, J. L., & Silva, C. G. (2022). Intensification strategies for improving the performance of photocatalytic processes: A review. Journal of Cleaner Production., 340, 130800.

    Article  Google Scholar 

  21. Khader, E. H., Mohammed, T. J., Albayati, T. M., Harharah, H. N., Amari, A., Saady, N. M. C., et al. (2023). Current trends for wastewater treatment technologies with typical configurations of photocatalytic membrane reactor hybrid systems: A review. Chemical Engineering and Processing-Process Intensification, 192, 109503.

  22. Hassanzadeh, S., Eisavi, R., & Abbasian, M. (2019). Green synthesis of thiiranes from epoxides catalyzed by magnetically separable CuFe2O4/Mg (OH) 2 nanocomposite in water under benign conditions. Journal of Sulfur Chemistry., 40(3), 240–255.

    Article  Google Scholar 

  23. Ramazani, A., Taghavi Fardood, S., Hosseinzadeh, Z., Sadri, F., & Joo, S. W. (2017). Green synthesis of magnetic copper ferrite nanoparticles using tragacanth gum as a biotemplate and their catalytic activity for the oxidation of alcohols. Iranian Journal of Catalysis., 7(3), 181–185.

    Google Scholar 

  24. Dippong, T., Cadar, O., & Levei, E. A. (2022). Effect of transition metal do** on the structural, morphological, and magnetic properties of NiFe2O4. Materials., 15(9), 2996.

    Article  Google Scholar 

  25. Arumugham, N., Mariappan, A., Eswaran, J., Daniel, S., Kanthapazham, R., & Kathirvel, P. (2022). Nickel ferrite-based composites and its photocatalytic application–A review. Journal of Hazardous Materials Advances, 8, 100156.

  26. Derakhshani, E., Naghizadeh, A., & Mortazavi-Derazkola, S. (2024). Superior UVC light-mediated catalytic activity of a novel NiFe2O4@ TiO2 magnetic nanocomposite synthesized with green route using Pulicaria Gnaphalodes plant extract for enhanced photocatalytic degradation of an antibiotic in water solution. Applied Water Science., 14(2), 17.

    Article  Google Scholar 

  27. Yousefi, M., Gholami, M., Oskoei, V., Mohammadi, A. A., Baziar, M., & Esrafili, A. (2021). Comparison of LSSVM and RSM in simulating the removal of ciprofloxacin from aqueous solutions using magnetization of functionalized multi-walled carbon nanotubes: Process optimization using GA and RSM techniques. Journal of Environmental Chemical Engineering., 9(4), 105677.

    Article  Google Scholar 

  28. Selvakumar, G., & Palanivel, C. (2022). A study on synthesis, characterization and catalytic applications of MoO3-ZnO nanocompositematerial. Materials Science for Energy Technologies., 5, 36–44.

    Article  Google Scholar 

  29. Masoudi, F., Naghizadeh, A., Zardast, M., Gholami, A., Farrokhfall, K., Foadoddini, M., et al. (2020). Effects of bentonite nanoparticles inhalation on lung tissue and blood antioxidant indices in a rat model. Toxicology and Industrial Health., 36(1), 11–21.

    Article  Google Scholar 

  30. Hosseini, H., & Mahdavi, H. (2018). Nanocomposite based on epoxy and MWCNTs modified with NiFe2O4 nanoparticles as efficient microwave absorbing material. Applied Organometallic Chemistry., 32(4), e4294.

    Article  Google Scholar 

  31. Khairy, M. (2014). Synthesis, characterization, magnetic and electrical properties of polyaniline/NiFe2O4 nanocomposite. Synthetic metals., 189, 34–41.

    Article  Google Scholar 

  32. Gebreslassie, G., Bharali, P., Chandra, U., Sergawie, A., Baruah, P. K., Das, M. R., et al. (2019). Hydrothermal synthesis of g-C3N4/NiFe2O4 nanocomposite and its enhanced photocatalytic activity. Applied Organometallic Chemistry., 33(8), e5002.

    Article  Google Scholar 

  33. Wang, Q., Pang, W., Mao, Y., Sun, Q., Zhang, P., Ke, Q., et al. (2019). Study of the degradation of trimethoprim using photo-Fenton oxidation technology. Water, 11(2), 207.

    Article  Google Scholar 

  34. Samy, M., Ibrahim, M. G., Alalm, M. G., Fujii, M., Ookawara, S., & Ohno, T. (2020). Photocatalytic degradation of trimethoprim using S-TiO2 and Ru/WO3/ZrO2 immobilized on reusable fixed plates. Journal of Water Process Engineering., 33, 101023.

    Article  Google Scholar 

  35. Asri, M., Naghizadeh, A., Hasani, A., Mortazavi-Derazkola, S., Javid, A., & Masoudi, F. (2023). Sustainable green synthesis of ZnFe2O4@ ZnO nanocomposite using Oleaster tree bark methanolic extract for photocatalytic degradation of aqueous humic acid in the presence of UVc irradiation. AQUA—Water Infrastructure, Ecosystems and Society, 72(9), 1800–1814.

  36. Derakhshani, E., & Naghizadeh, A. (2023). Recent advancement in NiFe2O4-based nanocomposites for the photocatalytic degradation of pollutants in aqueous solutions: A comprehensive systematic review. AQUA—Water Infrastructure, Ecosystems and Society, 72(8), 1629–1645.

  37. González, B., Trujillano, R., Vicente, M. A., Rives, V., Korili, S. A., & Gil, A. (2019). Photocatalytic degradation of trimethoprim on doped Ti-pillared montmorillonite. Applied Clay Science., 167, 43–49.

    Article  Google Scholar 

  38. Hossienzadeh, K., Maleki, A., Daraei, H., Safari, M., Pawar, R., & Lee, S. M. (2019). Sonocatalytic and photocatalytic efficiency of transition metal-doped ZnO nanoparticles in the removal of organic dyes from aquatic environments. Korean Journal of Chemical Engineering., 36, 1360–1370.

    Article  Google Scholar 

  39. Almasi, A., Dargahi, A., Mohamadi, M., Biglari, H., Amirian, F., & Raei, M. (2016). Removal of Penicillin G by combination of sonolysis and photocatalytic (sonophotocatalytic) process from aqueous solution: Process optimization using RSM (Response Surface Methodology). Electronic physician., 8(9), 2878.

    Article  Google Scholar 

  40. Esmati, M., Allahresani, A., & Naghizadeh, A. (2021). Synthesis and characterization of graphitic carbon nitride/mesoporous nano-silica (g-C3N4/KCC-1) nanocomposite as a novel highly efficient and recyclable photocatalyst for degradation of antibiotic in aqueous solution. Research on Chemical Intermediates., 47(4), 1447–1469.

    Article  Google Scholar 

  41. Vasseghian, Y., Sezgin, D., Nguyen, D. C., Hoang, H. Y., & Yilmaz, M. S. (2023). A hybrid nanocomposite based on CuFe layered double hydroxide coated graphene oxide for photocatalytic degradation of trimethoprim. Chemosphere, 322, 138243.

    Article  Google Scholar 

  42. Taie, M., Fadaei, A., Sadeghi, M., Hemati, S., & Mardani, G. (2021). Comparison of the efficiency of ultraviolet/zinc oxide (UV/ZnO) and ozone/zinc oxide (O3/ZnO) techniques as advanced oxidation processes in the removal of trimethoprim from aqueous solutions. International Journal of Chemical Engineering., 2021, 1–11.

    Article  Google Scholar 

  43. Oros-Ruiz, S., Zanella, R., & Prado, B. (2013). Photocatalytic degradation of trimethoprim by metallic nanoparticles supported on TiO2-P25. Journal of hazardous materials., 263, 28–35.

    Article  Google Scholar 

  44. Samy, M., Ibrahim, M. G., Alalm, M. G., & Fujii, M. (2020). MIL-53 (Al)/ZnO coated plates with high photocatalytic activity for extended degradation of trimethoprim via novel photocatalytic reactor. Separation and Purification Technology., 249, 117173.

    Article  Google Scholar 

  45. Martínez-Costa, J., Rivera-Utrilla, J., Leyva-Ramos, R., Sánchez-Polo, M., & Velo-Gala, I. (2018). Individual and simultaneous degradation of antibiotics sulfamethoxazole and trimethoprim by UV and solar radiation in aqueous solution using bentonite and vermiculite as photocatalysts. Applied Clay Science., 160, 217–225.

    Article  Google Scholar 

Download references

Acknowledgements

The authors express their gratitude to Birjand University of Medical Sciences for their support

of the present study.

Funding

The current project accepted and financially support in Research deputy of BUMS coded 6268.

Author information

Authors and Affiliations

  1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

    Sepideh Sahragard & Elham Derakhshani

  2. Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran

    Ali Naghizadeh, Sobhan Mortazavi-Derazkola & Elham Derakhshani

Authors
  1. Sepideh Sahragard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ali Naghizadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sobhan Mortazavi-Derazkola
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elham Derakhshani
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study design. Synthesis of nanocomposites was done by Elham Drakhshani and Sobhan Mortazavi. Conceptualization of the research was done by Ali Naghizadeh. Material preparation, experiments, and data analysis were done by Sepideh sahragard and Ali Naghizadeh. The initial manuscript was written by Sepideh Sahragard. All authors read and approved the article.

Corresponding authors

Correspondence to Ali Naghizadeh or Elham Derakhshani.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics Approval and Consent to Participate

The recent research project accepted in ethical committee of BUMS coded IR.BUMS.REC.1402.511. All authors consent to participate and publication of this paper.

Conflict of Interest

The authors affirm that there are no conflicts of interest related to the publication of this manuscript.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sahragard, S., Naghizadeh, A., Mortazavi-Derazkola, S. et al. Detoxification of Trimethoprim Antibiotic Using NiFe2O4@MoO3 Magnetic Nanocomposites Phyto-synthesized with Green Route: Experimental and RSM Modeling. BioNanoSci. 14, 1119–1131 (2024). https://doi.org/10.1007/s12668-024-01420-1

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12668-024-01420-1

Keywords

Search

Navigation