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The RNA Secondary Structure Analysis Reveals Potential for Emergence of Pathogenic Flaviviruses

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Abstract

The Flavivirus genus is divided into four groups: Mosquito-borne flaviviruses, Tick-borne flaviviruses, no-known vector flaviviruses, and Insect specific flaviviruses. Millions of people are affected worldwide every year due to the flaviviral infections. The 5' UTR of the RNA genome plays a critical role in the biology of flaviviruses. To explore any correlation between the topology of the 5' UTR and pathogenesis, a global scale study of the RNA secondary structure of different groups of flaviviruses has been conducted. We found that most of the pathogenic flaviviruses, irrespective of their mode of transmission, tend to form a Y shaped topology in the Stem loop A of the 5' UTR. Some of the current non-pathogenic flaviviruses were also observed to form Y shaped structure. Based on this study, it has been proposed that the flaviviruses having the Y shaped topology in their 5′ UTR regions may have the potential to become pathogenic.

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Acknowledgements

We would like to thank BITS Pilani, K K Birla Goa campus for providing the computational facilities. BM is funded by the PhD fellowship from BITS Pilani.

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  1. Bibhudutta Mishra

    Present address: Department of Zoology, Centurion University of Technology and Management, Bhubaneswar Campus, Khurda, Jatni, 752050, Odisha, India

Authors and Affiliations

  1. Department of Biological Sciences, Birla Institute of Technology and Science Pilani, K K Birla Goa campus, Zuarinagar, South Goa, 403726, India

    Bibhudutta Mishra & Raviprasad Aduri

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  1. Bibhudutta Mishra
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RA conceptualized and designed the methodology. BM carried out the data collection, structure prediction, and analysis. Both BM and RA contributed to the writing of the manuscript.

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Correspondence to Raviprasad Aduri.

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Mishra, B., Aduri, R. The RNA Secondary Structure Analysis Reveals Potential for Emergence of Pathogenic Flaviviruses. Food Environ Virol 14, 10–29 (2022). https://doi.org/10.1007/s12560-021-09502-z

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