Abstract
Hyperthermia with a radiofrequency electric field can treat a cancer by delivering energy to heat and kill cancer cells. For a deeply located tumor, focused energy to raise its local temperature selectively is crucial for effective cancer treatment with minimal injury to normal tissues. We evaluated the selective heating characteristics of hyperthermia with 13.56 MHz radiofrequency energy in phantom models by experimental and computational approaches. Phantom materials with different electrical properties such as distilled water, normal saline, egg white and porcine meat were used. Temperature rise in depthwise during heating at 75 W output power was compared. The temperature of the egg white increased selectively in the distilled water but not significantly in the saline. Numerical simulation was performed using SEMCAD X software to calculate the distributions of specific absorption rate (SAR) and temperature, which enabled us to elucidate the selective heating mechanism in those phantom models.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- ε :
-
permittivity
- φ :
-
electric potential
- E :
-
electric field strength
- SAR :
-
specific absorption rate
- σ :
-
electrical conductivity
- ρ :
-
mass density
- c :
-
specific heat
- T :
-
temperature
- t :
-
time
- k :
-
thermal conductivity
- Q r :
-
regional heat delivered by the source (= ρSAR)
References
Raoof, M., Cisneros, B. T., Corr, S. J., Palalon, F., Curley, S. A., and Koshkina, N. V., “Tumor Selective Hyperthermia Induced by Short-Wave Capacitively-Coupled RF Electric-Fields,” PLoS One, Vol. 8, No. 7, Paper No. e68506, 2013.
Paulides, M. M., Bakker, J. F., Linthorst, M., Van der Zee, J., Rijnen, Z., et al., “The Clinical Feasibility of Deep Hyperthermia Treatment in the Head and Neck: New Challenges for Positioning and Temperature Measurement,” Physics in Medicine and Biology, Vol. 55, No. 9, pp. 2465–2480, 2010.
Baronzio, G., Parmar, G., Ballerini, M., Szasz, A., and Baronzio, M., “A Brief Overview of Hyperthermia in Cancer Treatment,” Journal of the Society for Integrative Oncology, Vol. 3, No. 1, Paper No. 115, 2014.
Nagy, G., Meggyeshazi, N., and Szasz, O., “Deep Temperature Measurements in Oncothermia Processes,” Conference Papers in Medicine, Vol. 2013, Article ID: 685264, 2013.
Szasz, A., Szasz, N., and Szasz, O., “Oncothermia: Principles and Practices,” Springer Science & Business Media, pp. 173–181, 2010.
Hasgall, P. A., Di Gennaro, F., Baumgartner, C., Neufeld, E., Gosselin, M. C., et al., “IT’IS Database for Thermal and Electromagnetic Parameters of Biological Tissues,” Version 3.0, 2015, DOI: 10.13099/VIP21000-03-0. www.itis.ethz.ch/database
Coimbra, J. S. R., Gabas, A. L., Minim, L. A., Rojas, E. E. G., Telis, V. R., and Telis-Romero, J., “Density, Heat Capacity and Thermal Conductivity of Liquid Egg Products,” Journal of Food Engineering, Vol. 74, No. 2, pp. 186–190, 2006.
Amiali, M., Ngadi, M. O., Raghavan, V. G. S., and Nguyen, D., “Electrical Conductivities of Liquid Egg Products and Fruit Juices Exposed to High Pulsed Electric Fields,” International Journal of Food Properties, Vol. 9, No. 3, pp. 533–540, 2006.
SPEAG, “Product information of SEMCAD X,” http://www.speag. com/products/semcad/intro/ (Accessed 9 JUN 2015)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hossain, M.T., Prasad, B., Park, K.S. et al. Simulation and experimental evaluation of selective heating characteristics of 13.56 MHz radiofrequency hyperthermia in phantom models. Int. J. Precis. Eng. Manuf. 17, 253–256 (2016). https://doi.org/10.1007/s12541-016-0033-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12541-016-0033-9