Abstract
Background
The appropriate clinical approach to incidentally detected lesions (IDLs) on CT attenuation correction (CTAC) images in myocardial perfusion imaging (MPI) remains uncertain. We sought to establish their prevalence and clinical significance in a large cohort and compared to previous studies to help provide further clarity and guide future clinical practice.
Methods and Results
A total of 3758 MPI studies were reviewed retrospectively. IDLs of potential clinical significance—not known before MPI - were reported in 245 (6.5%) of these cases. Following appropriate further investigation/follow-up, these were of proven clinical significance in 30 (12.2%) cases with 14 patients (5.7%) harboring previously undiagnosed or progressive malignancies. The positive predictive value (PPV) for clinically significant incidental findings on CTAC images was 17.2% and the PPV value for incidental malignant findings was 8.0%.
Conclusion
Although incidental findings on CTAC images in MPI are common and often clearly insignificant at time of MPI reporting, many are clinically significant with a relatively high positive predictive value. This is especially so for malignancies. Our findings, therefore, in combination with previous studies as described here support routine reporting and appropriate further investigation of incidental CTAC findings in MPI.
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Abbreviations
- CT:
-
Computed tomography
- CTAC:
-
Computed tomography attenuation correction
- IDL:
-
Incidentally detected lesion
- MPI:
-
Myocardial perfusion imaging
- SPECT:
-
Single-photon emission computed tomography
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Disclosure
Dr Lee has received travel expenses for attending meetings of his specialty College’s Continuing Professional Development Committee, of which he is a member. Dr Delaney has nothing to disclose.
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Lee, J.C., Delaney, F.T. Prevalence and clinical significance of incidental findings on CT attenuation correction for myocardial perfusion imaging. J. Nucl. Cardiol. 29, 1813–1822 (2022). https://doi.org/10.1007/s12350-020-02499-1
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DOI: https://doi.org/10.1007/s12350-020-02499-1