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Relapsing sclerosing mesenteritis with multiple strictures of the small intestine

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Abstract

Sclerosing mesenteritis (SM) is a rare disorder that involves the mesenteric adipose tissue with chronic fibrosing inflammation. Few reports mention the natural history of severe SM cases. Here, we report a severe and relapsing SM case in which a long-term natural history could be followed. The patient had undergone surgery for small bowel stenosis of unknown cause 10 years earlier. He had stopped visiting the hospital at his discretion. He was admitted to the hospital 10 years later due to recurrent symptoms, and a close examination revealed multiple small intestinal strictures; thus, surgery was performed again. The pathological results revealed that the patient had SM, corticosteroid administration dramatically improved his symptoms, and he has maintained remission for a long time.

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Abbreviations

SM:

Sclerosing mesenteritis

CT:

Computed tomography

CRP:

C-reactive protein

ESR:

Erythrocyte sedimentation rate

IGRA:

Interferon-gamma release assay

NSAID:

Nonsteroidal anti-inflammatory drug

CEAS:

Chronic enteropathy associated with SLCO2A1

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Funding

The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this article. This work was supported by JSPS KAKENHI Grant Number JP21K15947.

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Authors and Affiliations

  1. Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan

    Masashi Ohno, Atsushi Nishida, Takayuki Imai & Osamu Inatomi

  2. Department of Gastroenterology and Hepatology, Nagahama City Hospital, Nagahama, Shiga, 526-8580, Japan

    Masashi Ohno, Atsushi Nishida & Kenichiro Takahashi

  3. Department of Surgery, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan

    Toru Miyake & Masaji Tani

  4. Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan

    Eri Tanaka & Ryoji Kushima

Authors
  1. Masashi Ohno
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  2. Atsushi Nishida
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  3. Takayuki Imai
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  4. Eri Tanaka
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  5. Kenichiro Takahashi
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  7. Masaji Tani
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  8. Ryoji Kushima
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  9. Osamu Inatomi
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Correspondence to Masashi Ohno.

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Ohno, M., Nishida, A., Imai, T. et al. Relapsing sclerosing mesenteritis with multiple strictures of the small intestine. Clin J Gastroenterol (2024). https://doi.org/10.1007/s12328-024-01989-w

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