Abstract
Ocular diseases are a growing global concern and have a significant impact on the quality of life. Cataracts, glaucoma, age-related macular degeneration, and diabetic retinopathy are the most prevalent ocular diseases. Their prevalence and the global market size are also increasing. However, the available pharmacotherapy is currently limited. These diseases share common pathophysiological features, including neovascularization, inflammation, and/or neurodegeneration. Histone deacetylases (HDACs) are a class of enzymes that catalyze the removal of acetyl groups from lysine residues of histone and nonhistone proteins. HDACs are crucial for regulating various cellular processes, such as gene expression, protein stability, localization, and function. They have also been studied in various research fields, including cancer, inflammatory diseases, neurological disorders, and vascular diseases. Our study aimed to investigate the relationship between HDACs and ocular diseases, to identify a new strategy for pharmacotherapy. This review article explores the role of HDACs in ocular diseases, specifically focusing on diabetic retinopathy, age-related macular degeneration, and retinopathy of prematurity, as well as optic nerve disorders, such as glaucoma and optic neuropathy. Additionally, we explore the interplay between HDACs and key regulators of fibrosis and angiogenesis, such as TGF-β and VEGF, highlighting the potential of targeting HDAC as novel therapeutic strategies for ocular diseases.
Similar content being viewed by others
References
Abouhish H, Thounaojam MC, Jadeja RN, Gutsaeva DR, Powell FL, Khriza M, Martin PM, Bartoli M (2020) Inhibition of HDAC6 attenuates diabetes-induced retinal Redox imbalance and microangiopathy. Antioxid (Basel). https://doi.org/10.3390/antiox9070599
Adamis AP, Shima DT (2005) The role of vascular endothelial growth factor in ocular health and disease. RETINA. https://doi.org/10.1097/00006982-200502000-00001
Akhurst RJ, Hata A (2012) Targeting the TGFbeta signalling pathway in disease. Nat Rev Drug Discov 11:790–811. https://doi.org/10.1038/nrd3810
Alagorie AR, Velaga S, Nittala MG, Yu HJ, Wykoff CC, Sadda SR (2021) Effect of aflibercept on diabetic retinopathy severity and visual function in the recovery study for proliferative diabetic retinopathy. Ophthalmol Retina 5:409–419. https://doi.org/10.1016/j.oret.2020.08.018
Alajbegovic-Halimic J, Zvizdic D, Alimanovic-Halilovic E, Dodik I, Duvnjak S (2015) Risk factors for retinopathy of prematurity in premature born children. Med Arch 69:409–413. https://doi.org/10.5455/medarh.2015.69.409-413
Aune TM, Collins PL, Chang S (2009) Epigenetics and T helper 1 differentiation. Immunology 126:299–305. https://doi.org/10.1111/j.1365-2567.2008.03026.x
Ayer DE (1999) Histone deacetylases: transcriptional repression with SINers and NuRDs. Trends Cell Biol 9:193–198. https://doi.org/10.1016/s0962-8924(99)01536-6
Azuchi Y, Kimura A, Guo X, Akiyama G, Noro T, Harada C, Nishigaki A, Namekata K, Harada T (2017) Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis. Neurosci Lett 639:82–87. https://doi.org/10.1016/j.neulet.2016.12.057
Bahl S, Seto E (2021) Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance. Cell Mol Life Sci 78:427–445. https://doi.org/10.1007/s00018-020-03599-4
Bahn G, Jo DG (2019) Therapeutic approaches to Alzheimer’s disease through modulation of NRF2. Neuromol Med 21:1–11. https://doi.org/10.1007/s12017-018-08523-5
Bardai FH, D’mello SR (2011) Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3β. J Neurosci 31:1746–1751. https://doi.org/10.1523/jneurosci.5704-10.2011
Baudouin C, Kolko M, Melik-Parsadaniantz S, Messmer EM (2021) Inflammation in glaucoma: from the back to the front of the eye, and beyond. Prog Retin Eye Res 83:100916. https://doi.org/10.1016/j.preteyeres.2020.100916
Bell EL, Emerling BM, Ricoult SJ, Guarente L (2011) SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30:2986–2996. https://doi.org/10.1038/onc.2011.37
Bellezza AJ, Rintalan CJ, Thompson HW, Downs JC, Hart RT, Burgoyne CF (2003) Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma. Investig Ophthalmol Vis Sci 44:623–637. https://doi.org/10.1167/iovs.01-1282
Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, **a F, Holson EB, Khabele D, Hiebert SW (2010) Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell 18:436–447. https://doi.org/10.1016/j.ccr.2010.10.022
Bowen H, Kelly A, Lee T, Lavender P (2008) Control of cytokine gene transcription in Th1 and Th2 cells. Clin Exp Allergy 38:1422–1431. https://doi.org/10.1111/j.1365-2222.2008.03067.x
Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB (1990) Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature 347:677–680. https://doi.org/10.1038/347677a0
Bowes Rickman C, Farsiu S, Toth CA, Klingeborn M (2013) Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci 54:ORSF68–80. https://doi.org/10.1167/iovs.13-12757
Brehm A, Miska EA, Mccance DJ, Reid JL, Bannister AJ, Kouzarides T (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature 391:597–601. https://doi.org/10.1038/35404
Brown DM, Schmidt-Erfurth U, Do DV, Holz FG, Boyer DS, Midena E, Heier JS, Terasaki H, Kaiser PK, Marcus DM (2015) Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies. Ophthalmology 122:2044–2052. https://doi.org/10.1016/j.ophtha.2015.06.017
Brown DM, Wykoff CC, Boyer D, Heier JS, Clark WL, Emanuelli A, Higgins PM, Singer M, Weinreich DM, Yancopoulos GD, Berliner AJ, Chu K, Reed K, Cheng Y, Vitti R (2021) Evaluation of intravitreal aflibercept for the treatment of severe nonproliferative diabetic retinopathy: results from the panorama randomized clinical trial. JAMA Ophthalmol 139:946–955. https://doi.org/10.1001/jamaophthalmol.2021.2809
Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT (2005) The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog Retin Eye Res 24:39–73. https://doi.org/10.1016/j.preteyeres.2004.06.001
Cai X, Li J, Wang M, She M, Tang Y, Li J, Li H, Hui H (2017) GLP-1 treatment improves diabetic retinopathy by alleviating autophagy through GLP-1R-ERK1/2-HDAC6 signaling pathway. Int J Med Sci 14:1203–1212. https://doi.org/10.7150/ijms.20962
Cai J, Drewry MD, Perkumas K, Dismuke WM, Hauser MA, Stamer WD, Liu Y (2020) Differential DNA methylation patterns in human Schlemm’s canal endothelial cells with glaucoma. Mol Vis 26:483–493
Cantley MD, Haynes DR (2013) Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs. Inflammopharmacology 21:301–307. https://doi.org/10.1007/s10787-012-0166-0
Capitao M, Soares R (2016) Angiogenesis and inflammation crosstalk in diabetic retinopathy. J Cell Biochem 117:2443–2453. https://doi.org/10.1002/jcb.25575
Chalam KV, Grover S, Sambhav K, Balaiya S, Murthy RK (2014) Aqueous interleukin-6 levels are superior to vascular endothelial growth factor in predicting therapeutic response to bevacizumab in age-related macular degeneration. J Ophthalmol. https://doi.org/10.1155/2014/502174
Chalkiadaki A, Guarente L (2015) The multifaceted functions of sirtuins in cancer. Nat Rev Cancer 15:608–624. https://doi.org/10.1038/nrc3985
Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR (2002) Retinal degeneration mutants in the mouse. Vision Res 42:517–525. https://doi.org/10.1016/S0042-6989(01)00146-8
Chang B, Hawes NL, Pardue MT, German AM, Hurd RE, Davisson MT, Nusinowitz S, Rengarajan K, Boyd AP, Sidney SS, Phillips MJ, Stewart RE, Chaudhury R, Nickerson JM, Heckenlively JR, Boatright JH (2007) Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vis Res 47:624–633. https://doi.org/10.1016/j.visres.2006.11.020
Chansangpetch S, Prombhul S, Tantisevi V, Sodsai P, Manassakorn A, Hirankarn N, Lin SC (2018) DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E, and HERV-K in trabeculectomy specimens from glaucoma eyes. J Ophthalmol. https://doi.org/10.1155/2018/9171536
Chatziralli I (2021) Ranibizumab for the treatment of diabetic retinopathy. Expert Opin Biol Ther 21:991–997. https://doi.org/10.1080/14712598.2021.1928629
Che S, Wu S, Yu P (2022) Downregulated HDAC3 or up-regulated microRNA-296-5p alleviates diabetic retinopathy in a mouse model. Regen Ther 21:1–8. https://doi.org/10.1016/j.reth.2022.04.002
Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE (2013) Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis 16:985–992. https://doi.org/10.1007/s10456-013-9374-5
Chen IC, Chiang W-F, Huang H-H, Chen P-F, Shen Y-Y, Chiang H-C (2014) Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. Mol Cancer 13:254. https://doi.org/10.1186/1476-4598-13-254
Chen S, Yin C, Lao T, Liang D, He D, Wang C, Sang N (2015) AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1alpha and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle 14:2520–2536. https://doi.org/10.1080/15384101.2015.1055426
Chen CL, Chen YH, Tai MC, Liang CM, Lu DW, Chen JT (2017) Resveratrol inhibits transforming growth factor-beta2-induced epithelial-to-mesenchymal transition in human retinal pigment epithelial cells by suppressing the smad pathway. Drug Des Devel Ther 11:163–173. https://doi.org/10.2147/DDDT.S126743
Chen B, Wu L, Cao T, Zheng H-M, He T (2020) MiR-221/SIRT1/Nrf2 signal axis regulates high glucose induced apoptosis in human retinal microvascular endothelial cells. BMC Ophthalmol 20:300. https://doi.org/10.1186/s12886-020-01559-x
Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376:124–136. https://doi.org/10.1016/S0140-6736(09)62124-3
Chiquet C, Vignal C, Gohier P, Heron E, Thuret G, Rougier MB, Lehmann A, Flet L, Quesada JL, Roustit M, Milea D, Pepin JL, Group E (2022) Treatment of nonarteritic anterior ischemic optic neuropathy with an endothelin antagonist: endothelion (endothelin antagonist receptor in ischemic optic neuropathy)-a multicentre randomised controlled trial protocol. Trials 23:916. https://doi.org/10.1186/s13063-022-06786-9
Cho Y, Bae HG, Okun E, Arumugam TV, Jo DG (2022) Physiology and pharmacology of amyloid precursor protein. Pharmacol Ther 235:108122. https://doi.org/10.1016/j.pharmthera.2022.108122
Clemson CM, Tzekov R, Krebs M, Checchi JM, Bigelow C, Kaushal S (2011) Therapeutic potential of valproic acid for retinitis pigmentosa. Br J Ophthalmol 95:89–93. https://doi.org/10.1136/bjo.2009.175356
Congdon NG, Youlin Q, Quigley H, Hung T, Wang T, Ho T, Tielsch JM (1997) Biometry and primary angle-closure glaucoma among Chinese, white, and black populations. Ophthalmology 104:1489–1495
Crosson CE, Mani SK, Husain S, Alsarraf O, Menick DR (2010) Inhibition of histone deacetylase protects the retina from ischemic injury. Invest Ophthalmol Vis Sci 51:3639–3645. https://doi.org/10.1167/iovs.09-4538
Dahbash M, Sella R, Megiddo-Barnir E, Nisgav Y, Tarasenko N, Weinberger D, Rephaeli A, Livnat T (2019) The histone deacetylase inhibitor AN7, attenuates choroidal neovascularization in a mouse model. Int J Mol Sci. https://doi.org/10.3390/ijms20030714
Dalgard CL, Van Quill KR, O’brien JM (2008) Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. Clin Cancer Res 14:3113–3123. https://doi.org/10.1158/1078-0432.CCR-07-4836
Dandona L, Dandona R, Mandal P, Srinivas M, John RK, Mccarty CA, Rao GN (2000) Angle-closure glaucoma in an urban population in southern India: the Andhra Pradesh eye disease study. Ophthalmology 107:1710–1716
Deng Y, Qiao L, Du M, Qu C, Wan L, Li J, Huang L (2022) Age-related macular degeneration: epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy. Genes Dis 9:62–79. https://doi.org/10.1016/j.gendis.2021.02.009
Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, Verdin E (2003) HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 18:687–698. https://doi.org/10.1016/s1074-7613(03)00109-2
Deskin B, Lasky J, Zhuang Y, Shan B (2016) Requirement of HDAC6 for activation of Notch1 by TGF-beta1. Sci Rep 6:31086. https://doi.org/10.1038/srep31086
Dimaras H, Kimani K, Dimba EO, Gronsdahl P, White A, Chan HSL, Gallie BL (2012) Retinoblastoma. Lancet 379:1436–1446. https://doi.org/10.1016/S0140-6736(11)61137-9
Dovey OM, Foster CT, Conte N, Edwards SA, Edwards JM, Singh R, Vassiliou G, Bradley A, Cowley SM (2013) Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice. Blood 121:1335–1344. https://doi.org/10.1182/blood-2012-07-441949
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334:806–809. https://doi.org/10.1126/science.1207861
Dubey R, Dubey SK, Jung KS, Mohan K, Kleinman ME (2022) CCL26 expression is elevated in the retinal pigment epithelium in atrophic AMD. Investig Ophthalmol Vis Sci 63:28–28
Dworak DP, Nichols J (2014) A review of optic neuropathies. Dis Mon 60:276–281. https://doi.org/10.1016/j.disamonth.2014.03.008
Eckschlager T, Plch J, Stiborova M, Hrabeta J (2017) Histone deacetylase inhibitors as anticancer drugs. Int J Mol Sci. https://doi.org/10.3390/ijms18071414
Ellmeier W, Seiser C (2018) Histone deacetylase function in CD4 + T cells. Nat Rev Immunol 18:617–634. https://doi.org/10.1038/s41577-018-0037-z
Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, Ferris Iii FL, Friedman SM, Glassman AR, Miller KM (2010) Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 117:1064–1077. https://doi.org/10.1016/j.ophtha.2010.02.031
Falkenberg KJ, Johnstone RW (2014) Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discovery 13:673–691. https://doi.org/10.1038/nrd4360
Fan J, Alsarraf O, Dahrouj M, Platt KA, Chou CJ, Rice DS, Crosson CE (2013) Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci 54:4072–4080. https://doi.org/10.1167/iovs.12-11529
Feng J, Yan PF, Zhao HY, Zhang FC, Zhao WH, Feng M (2016) SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and suppression of JAK2/STAT3 signaling pathway activation. Oncol Rep 35:1395–1402. https://doi.org/10.3892/or.2015.4477
Ferrara N (2016) VEGF and intraocular neovascularization: from discovery to therapy. Transl Vis Sci Technol 5:10–10 https://doi.org/10.1167/tvst.5.2.10
Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC (2011) SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization. Cancer Cell 19:416–428. https://doi.org/10.1016/j.ccr.2011.02.014
Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY (2021) Age-related macular degeneration. Nat Rev Dis Primers 7:31. https://doi.org/10.1038/s41572-021-00265-2
Flores R, Carneiro A, Vieira M, Tenreiro S, Seabra MC (2021) Age-related macular degeneration: pathophysiology, management, and future perspectives. Ophthalmologica 244:495–511. https://doi.org/10.1159/000517520
Foster A, Resnikoff S (2005) The impact of vision 2020 on global blindness. Eye (Lond) 19:1133–1135. https://doi.org/10.1038/sj.eye.6701973
Fu Y, Wang Y, Gao X, Li H, Yuan Y (2020) Dynamic expression of HDAC3 in db/db mouse RGCs and its relationship with apoptosis and autophagy. J Diabetes Res. https://doi.org/10.1155/2020/6086780
Fu Z, Li H, Wang Y (2021) Implication of retrobulbar and internal carotid artery blood-flow-volume alterations for the pathogenesis of non-arteritic anterior ischemic optic neuropathy. BMC Ophthalmol 21:309. https://doi.org/10.1186/s12886-021-02075-2
Fujimoto T, Inoue-Mochita M, Iraha S, Tanihara H, Inoue T (2021) Suberoylanilide hydroxamic acid (SAHA) inhibits transforming growth factor-beta 2-induced increases in aqueous humor outflow resistance. J Biol Chem 297:101070. https://doi.org/10.1016/j.jbc.2021.101070
Geng H, Harvey CT, Pittsenbarger J, Liu Q, Beer TM, Xue C, Qian DZ (2011) HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia. J Biol Chem 286:38095–38102. https://doi.org/10.1074/jbc.M111.257055
Glauben R, Sonnenberg E, Zeitz M, Siegmund B (2009) HDAC inhibitors in models of inflammation-related tumorigenesis. Cancer Lett 280:154–159. https://doi.org/10.1016/j.canlet.2008.11.019
Goldstein GP, Leonard SA, Kan P, Koo EB, Lee HC, Carmichael SL (2019) Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity. J Perinatol 39:964–973. https://doi.org/10.1038/s41372-019-0357-2
Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schlüter OM, Bradke F, Lu J, Fischer A (2013) Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease. EMBO Mol Med 5:52–63. https://doi.org/10.1002/emmm.201201923
Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483:222–226. https://doi.org/10.1038/nature10849
Grönroos E, Hellman U, Heldin C-H, Ericsson J (2002) Control of Smad7 stability by competition between acetylation and ubiquitination. Mol Cell 10:483–493. https://doi.org/10.1016/S1097-2765(02)00639-1
Gu S, Liu Y, Zhu B, Ding K, Yao TP, Chen F, Zhan L, Xu P, Ehrlich M, Liang T, Lin X, Feng XH (2016) Loss of alpha-tubulin acetylation is associated with TGF-beta-induced epithelial-mesenchymal transition. J Biol Chem 291:5396–5405. https://doi.org/10.1074/jbc.M115.713123
Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, Depinho RA, Jaenisch R, Tsai LH (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55–60. https://doi.org/10.1038/nature07925
Guo X, Yan F, Li J, Zhang C, Bu P (2017) SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway. Am J Transl Res 9:3258–3269
Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, Mckinsey TA, Olson EN, ** ZG (2008) Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J Biol Chem 283:14590–14599. https://doi.org/10.1074/jbc.M800264200
Hachana S, Larrivee B (2022) TGF-beta superfamily signaling in the eye: implications for ocular pathologies. Cells 11. https://doi.org/10.3390/cells11152336
Hachana S, Fontaine O, Sapieha P, Lesk M, Couture R, Vaucher E (2020) The effects of anti-VEGF and kinin B(1) receptor blockade on retinal inflammation in laser-induced choroidal neovascularization. Br J Pharmacol 177:1949–1966. https://doi.org/10.1111/bph.14962
Hai Y, Shinsky SA, Porter NJ, Christianson DW (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun 8:15368. https://doi.org/10.1038/ncomms15368
Hamel C (2006) Retinitis pigmentosa. Orphanet J Rare Dis 1:40. https://doi.org/10.1186/1750-1172-1-40
Hamid MA, Moustafa MT, Nashine S, Costa RD, Schneider K, Atilano SR, Kuppermann BD, Kenney MC (2021) Anti-VEGF drugs influence epigenetic regulation and AMD-specific molecular markers in ARPE-19 cells. Cells. https://doi.org/10.3390/cells10040878
Hammer SS, Vieira CP, Mcfarland D, Sandler M, Levitsky Y, Dorweiler TF, Lydic TA, Asare-Bediako B, Adu-Agyeiwaah Y, Sielski MS, Dupont M, Longhini AL, Li Calzi S, Chakraborty D, Seigel GM, Proshlyakov DA, Grant MB, Busik JV (2021) Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction. Diabetologia 64:1674–1689. https://doi.org/10.1007/s00125-021-05431-5
Harada T, Harada C, Nakamura K, Quah HM, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, Tanaka K (2007) The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest 117:1763–1770. https://doi.org/10.1172/jci30178
Hartnett ME, Lane RH (2013) Effects of oxygen on the development and severity of retinopathy of prematurity. J AAPOS 17:229–234. https://doi.org/10.1016/j.jaapos.2012.12.155
Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. The Lancet 368:1795–1809. https://doi.org/10.1016/S0140-6736(06)69740-7
Heideman MR, Wilting RH, Yanover E, Velds A, De Jong J, Kerkhoven RM, Jacobs H, Wessels LF, Dannenberg JH (2013) Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function. Blood 121:2038–2050. https://doi.org/10.1182/blood-2012-08-450916
Heier JS, Korobelnik J-F, Brown DM, Schmidt-Erfurth U, Do DV, Midena E, Boyer DS, Terasaki H, Kaiser PK, Marcus DM (2016) Intravitreal aflibercept for diabetic macular edema: 148-week results from the VISTA and VIVID studies. Ophthalmology 123:2376–2385. https://doi.org/10.1016/j.ophtha.2016.07.032
Heijl A (2015) Glaucoma treatment: by the highest level of evidence. The Lancet 385:1264–1266. https://doi.org/10.1016/S0140-6736(14)62347-3
Henley SA, Dick FA (2012) The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Div 7:10. https://doi.org/10.1186/1747-1028-7-10
Herskovits AZ, Guarente L (2013) Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res 23:746–758. https://doi.org/10.1038/cr.2013.70
Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225–238. https://doi.org/10.1038/nrm3293
Hsu MY, Hung YC, Hwang DK, Lin SC, Lin KH, Wang CY, Choi HY, Wang YP, Cheng CM (2016) Detection of aqueous VEGF concentrations before and after intravitreal injection of anti-VEGF antibody using low-volume sampling paper-based ELISA. Sci Rep 6:34631. https://doi.org/10.1038/srep34631
Hsu TJ, Nepali K, Tsai CH, Imtiyaz Z, Lin FL, Hsiao G, Lai MJ, Cheng YW (2021) The HDAC/HSP90 Inhibitor G570 attenuated blue light-induced cell migration in RPE Cells and neovascularization in mice through decreased VEGF production. Molecules. https://doi.org/10.3390/molecules26144359
Hu E, Chen Z, Fredrickson T, Zhu Y, Kirkpatrick R, Zhang GF, Johanson K, Sung CM, Liu R, Winkler J (2000) Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. J Biol Chem 275:15254–15264. https://doi.org/10.1074/jbc.M908988199
Hu F, Sun X, Li G, Wu Q, Chen Y, Yang X, Luo X, Hu J, Wang G (2018) Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway. Cell Death Dis 10:9. https://doi.org/10.1038/s41419-018-1260-z
Huang XZ, Wen D, Zhang M, **e Q, Ma L, Guan Y, Ren Y, Chen J, Hao CM (2014) Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-β/Smad3 pathway. J Cell Biochem 115:996–1005. https://doi.org/10.1002/jcb.24748
Iizuka N, Morita A, Kawano C, Mori A, Sakamoto K, Kuroyama M, Ishii K, Nakahara T (2018) Anti-angiogenic effects of valproic acid in a mouse model of oxygen-induced retinopathy. J Pharmacol Sci 138:203–208. https://doi.org/10.1016/j.jphs.2018.10.004
Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu A, Onozaki K, Hayashi H (2007) Smad3 is acetylated by p300/CBP to regulate its transactivation activity. Oncogene 26:500–508. https://doi.org/10.1038/sj.onc.1209826
Ishida T, Yoshida T, Shinohara K, Cao K, Nakahama KI, Morita I, Ohno-Matsui K (2017) Potential role of sirtuin 1 in Muller glial cells in mice choroidal neovascularization. PLoS One 12:e0183775. https://doi.org/10.1371/journal.pone.0183775
Jampol LM, Glassman AR, Sun J (2020) Evaluation and care of patients with diabetic retinopathy. N Engl J Med 382:1629–1637. https://doi.org/10.1056/NEJMra1909637
Ji Q, Han J, Wang L, Liu J, Dong Y, Zhu K, Shi L (2020) MicroRNA-34a promotes apoptosis of retinal vascular endothelial cells by targeting SIRT1 in rats with diabetic retinopathy. Cell Cycle 19:2886–2896. https://doi.org/10.1080/15384101.2020.1827509
Jo DH, Bae J, Chae S, Kim JH, Han J-H, Hwang D, Lee S-W, Kim JH (2016) Quantitative proteomics reveals β2 integrin-mediated cytoskeletal rearrangement in vascular endothelial growth factor (VEGF)-induced retinal vascular hyperpermeability*. Mol Cell Proteom 15:1681–1691. https://doi.org/10.1074/mcp.M115.053249
Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S (2017) Glaucoma. Lancet 390:2183–2193. https://doi.org/10.1016/s0140-6736(17)31469-1
Kale N (2016) Optic neuritis as an early sign of multiple sclerosis. Eye Brain 8:195–202. https://doi.org/10.2147/EB.S54131
Kaluza D, Kroll J, Gesierich S, Yao T-P, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C (2011) Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J 30:4142–4156. https://doi.org/10.1038/emboj.2011.298
Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, Zelent A, Rossig L, Zeiher AM, Augustin HG, Urbich C, Dimmeler S (2013) Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells. Arterioscler Thromb Vasc Biol 33:533–543. https://doi.org/10.1161/ATVBAHA.112.300415
Kametani Y, Wang L, Koduka K, Sato T, Katano I, Habu S (2008) Rapid histone deacetylation and transient HDAC association in the IL-2 promoter region of TSST-1-stimulated T cells. Immunol Lett 119:97–102. https://doi.org/10.1016/j.imlet.2008.05.006
Kasetti RB, Maddineni P, Patel PD, Searby C, Sheffield VC, Zode GS (2018) Transforming growth factor beta2 (TGFbeta2) signaling plays a key role in glucocorticoid-induced ocular hypertension. J Biol Chem 293:9854–9868. https://doi.org/10.1074/jbc.RA118.002540
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK, Wilson MR, Gordon MO, Group OHTS (2002) The ocular hypertension treatment study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol 120:701–713
Kato H, Tamamizu-Kato S, Shibasaki F (2004) Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem 279:41966–41974. https://doi.org/10.1074/jbc.M406320200
Kazantsev AG, Thompson LM (2008) Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 7:854–868. https://doi.org/10.1038/nrd2681
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. Embo J 26:3169–3179. https://doi.org/10.1038/sj.emboj.7601758
Kim JH, Kim JH, Oh M, Yu YS, Kim KW, Kwon HJ (2009) N-hydroxy-7-(2-naphthylthio) heptanomide inhibits retinal and choroidal angiogenesis. Mol Pharm 6:513–519. https://doi.org/10.1021/mp800178b
Kim M, Kim T-W, Park KH, Kim JM (2012a) Risk factors for primary open-angle glaucoma in South Korea: the Namil study. Jpn J Ophthalmol 56:324–329. https://doi.org/10.1007/s10384-012-0153-4
Kim MS, Akhtar MW, Adachi M, Mahgoub M, Bassel-Duby R, Kavalali ET, Olson EN, Monteggia LM (2012b) An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci 32:10879–10886. https://doi.org/10.1523/jneurosci.2089-12.2012
Kim KE, Kim MJ, Park KH, Jeoung JW, Kim SH, Kim CY, Kang SW, Society O (2016) Prevalence, awareness, and risk factors of primary open-angle glaucoma: Korea National Health and Nutrition Examination Survey. Ophthalmology. https://doi.org/10.1016/j.ophtha.2015.11.004
Kim JY, Cho H, Yoo J, Kim GW, Jeon YH, Lee SW, Kwon SH (2023) HDAC8 deacetylates HIF-1alpha and enhances its protein stability to promote tumor growth and migration in melanoma. Cancers (Basel). https://doi.org/10.3390/cancers15041123
Kimura A, Guo X, Noro T, Harada C, Tanaka K, Namekata K, Harada T (2015) Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma. Neurosci Lett 588:108–113. https://doi.org/10.1016/j.neulet.2014.12.054
King A, Azuara-Blanco A, Tuulonen A (2013) Glaucoma. BMJ 346:f3518. https://doi.org/10.1136/bmj.f3518
Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 18:601–607. https://doi.org/10.1016/j.molcel.2005.04.021
Kowluru RA, Santos JM, Zhong Q (2014) Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol Vis Sci 55:5653–5660. https://doi.org/10.1167/iovs.14-14383
Kowluru RA, Mishra M, Kumar B (2016) Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1. Exp Eye Res 147:72–77. https://doi.org/10.1016/j.exer.2016.04.014
Kumar A, Midha N, Gogia V, Gupta S, Sehra S, Chohan A (2014) Efficacy of oral valproic acid in patients with retinitis pigmentosa. J Ocul Pharmacol Ther 30:580–586. https://doi.org/10.1089/jop.2013.0166
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S-I, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D (2007) SIRT1 inhibits transforming growth factor β-Induced apoptosis in glomerular mesangial cells via Smad7 deacetylation*. J Biol Chem 282:151–158. https://doi.org/10.1074/jbc.M605904200
Lallemand F, Mazars A, Prunier C, Bertrand F, Kornprost M, Gallea S, Roman-Roman S, Cherqui G, Atfi A (2001) Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells. Oncogene 20:879–884. https://doi.org/10.1038/sj.onc.1204167
Lam D, Rao SK, Ratra V, Liu Y, Mitchell P, King J, Tassignon M-J, Jonas J, Pang CP, Chang DF (2015) Cataract. Nat Rev Dis Primers 1:15014. https://doi.org/10.1038/nrdp.2015.14
Lamoke F, Shaw S, Yuan J, Ananth S, Duncan M, Martin P, Bartoli M (2015) Increased oxidative and nitrative stress accelerates aging of the retinal vasculature in the Diabetic retina. PLoS One 10:e0139664. https://doi.org/10.1371/journal.pone.0139664
Lanzillotta A, Sarnico I, Ingrassia R, Boroni F, Branca C, Benarese M, Faraco G, Blasi F, Chiarugi A, Spano P, Pizzi M (2010) The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury. Cell Death Dis 1:e96–e96. https://doi.org/10.1038/cddis.2010.76
Lebrun-Julien F, Suter U (2015) Combined HDAC1 and HDAC2 depletion promotes retinal ganglion cell survival after Injury through reduction of p53 target gene expression. ASN Neuro 7:1759091415593066. https://doi.org/10.1177/1759091415593066
Leder A, Leder P (1975) Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Cell 5:319–322. https://doi.org/10.1016/0092-8674(75)90107-5
Leske MC (1983) The epidemiology of open-angle glaucoma: a review. Am J Epidemiol 118:166–191. https://doi.org/10.1093/oxfordjournals.aje.a113626
Leske MC, Wu S, Honkanen R, Nemesure B, Schachat A, Hyman L, Hennis A, Group BES (2007) Nine-year incidence of open-angle glaucoma in the Barbados Eye studies. Ophthalmology 114:1058–1064. https://doi.org/10.1016/j.ophtha.2006.08.051
Li Z, Wang F, Zha S, Cao Q, Sheng J, Chen S (2018) SIRT1 inhibits TGF-β-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation. J Cell Physiol 233:9007–9014. https://doi.org/10.1002/jcp.26846
Lim TH, Bae SH, Cho YJ, Lee JH, Kim HK, Sohn YH (2009) Concentration of vascular endothelial growth factor after intracameral bevacizumab injection in eyes with neovascular glaucoma. Korean J Ophthalmol 23:188–192. https://doi.org/10.3341/kjo.2009.23.3.188
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38:864–878. https://doi.org/10.1016/j.molcel.2010.05.023
Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY (2012) Age-related macular degeneration. Lancet 379:1728–1738. https://doi.org/10.1016/S0140-6736(12)60282-7
Liu H-N, Cao N-J, Li X, Qian W, Chen X-L (2018) Serum microRNA-211 as a biomarker for diabetic retinopathy via modulating Sirtuin 1. Biochem Biophys Res Commun 505:1236–1243. https://doi.org/10.1016/j.bbrc.2018.10.052
Lu XF, Cao XY, Zhu YJ, Wu ZR, Zhuang X, Shao MY, Xu Q, Zhou YJ, Ji HJ, Lu QR, Shi YJ, Zeng Y, Bu H (2018) Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway. Cell Death Dis 9:398. https://doi.org/10.1038/s41419-018-0428-x
Lundgren P, Athikarisamy SE, Patole S, Lam GC, Smith LE, Simmer K (2018) Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity. Acta Paediatr 107:759–766. https://doi.org/10.1111/apa.14187
Ma KS, Lee CM, Chen PH, Yang Y, Dong YW, Wang YH, Wei JC, Zheng WJ (2022) Risk of autoimmune diseases following optic neuritis: a nationwide population-based Cohort study. Front Med (Lausanne) 9:903608. https://doi.org/10.3389/fmed.2022.903608
Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A (1998) Retinoblastoma protein represses transcription by recruiting a histone deacetylase. Nature 391:601–605. https://doi.org/10.1038/35410
Maguire AM, Russell S, Wellman JA, Chung DC, Yu ZF, Tillman A, Wittes J, Pappas J, Elci O, Marshall KA, Mccague S, Reichert H, Davis M, Simonelli F, Leroy BP, Wright JF, High KA, Bennett J (2019) Efficacy, safety, and durability of voretigene neparvovec-rzyl in RPE65 mutation-associated inherited retinal dystrophy: results of phase 1 and 3 trials. Ophthalmology 126:1273–1285. https://doi.org/10.1016/j.ophtha.2019.06.017
Maity S, Muhamed J, Sarikhani M, Kumar S, Ahamed F, Spurthi KM, Ravi V, Jain A, Khan D, Arathi BP, Desingu PA, Sundaresan NR (2020) Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. J Biol Chem 295:415–434. https://doi.org/10.1074/jbc.RA118.007212
Maizel J, Xavier S, Chen J, Lin CH, Vasko R, Goligorsky MS (2014) Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction. Am J Physiol Heart Circ Physiol 307:H1691–H1704. https://doi.org/10.1152/ajpheart.00281.2014
Majdzadeh N, Morrison BE, D’mello SR (2008a) Class IIA HDACs in the regulation of neurodegeneration. Front Biosci 13:1072–1082. https://doi.org/10.2741/2745
Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D’mello SR (2008b) HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Dev Neurobiol 68:1076–1092. https://doi.org/10.1002/dneu.20637
Maloney SC, Antecka E, Granner T, Fernandes B, Lim LA, Orellana ME, Burnier MN Jr. (2013) Expression of SIRT1 in choroidal neovascular membranes. Retina 33:862–866. https://doi.org/10.1097/IAE.0b013e31826af556
Mao XB, Cheng YH, Peng KS, You ZP (2020) Sirtuin (Sirt) 3 overexpression prevents retinopathy in streptozotocin-induced diabetic rats. Med Sci Monit 26:e920883. https://doi.org/10.12659/msm.920883
Matsuda A, Asada Y, Takakuwa K, Sugita J, Murakami A, Ebihara N (2015) DNA methylation analysis of human trabecular meshwork cells during dexamethasone stimulation. Invest Ophthalmol Vis Sci 56:3801–3809. https://doi.org/10.1167/iovs.14-16008
Mcdonnell F, Irnaten M, Clark AF, O’brien CJ, Wallace DM (2016) Hypoxia-Induced changes in DNA methylation alter RASAL1 and TGFβ1 expression in human trabecular meshwork cells. PLoS One 11:e0153354. https://doi.org/10.1371/journal.pone.0153354
Mcevoy JD, Dyer MA (2015) Genetic and epigenetic discoveries in human retinoblastoma. Crit Rev Oncog 20:217–225. https://doi.org/10.1615/critrevoncog.2015013711
Mehta S (2015) Age-related macular degeneration. Prim Care 42:377–391. https://doi.org/10.1016/j.pop.2015.05.009
Michaelides M, Kaines A, Hamilton RD, Fraser-Bell S, Rajendram R, Quhill F, Boos CJ, **ng W, Egan C, Peto T (2010) A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study): 12-month data: report 2. Ophthalmology 117:1078–1086 e2
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67:953–966. https://doi.org/10.1016/j.neuron.2010.08.044
Mishra M, Kowluru RA (2017) Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy. Biochim Biophys Acta Mol Basis Dis 1863:1761–1769. https://doi.org/10.1016/j.bbadis.2017.04.024
Mishra M, Duraisamy AJ, Kowluru RA (2018) Sirt1: a guardian of the development of diabetic retinopathy. Diabetes 67:745–754. https://doi.org/10.2337/db17-0996
Mitchell P, Bandello F, Schmidt-Erfurth U, Lang GE, Massin P, Schlingemann RO, Sutter F, Simader C, Burian G, Gerstner O (2011) The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology 118:615–625
Mobley RJ, Raghu D, Duke LD, Abell-Hart K, Zawistowski JS, Lutz K, Gomez SM, Roy S, Homayouni R, Johnson GL, Abell AN (2017) MAP3K4 controls the chromatin modifier HDAC6 during trophoblast stem cell epithelial-to-mesenchymal transition. Cell Rep 18:2387–2400. https://doi.org/10.1016/j.celrep.2017.02.030
Moghimi S, Ramezani F, He M, Coleman AL, Lin SC (2015) Comparison of anterior segment-optical coherence tomography parameters in phacomorphic angle closure and acute angle closure eyes. Investig Ophthalmol Vis Sci 56:7611–7617
Mortuza R, Feng B, Chakrabarti S (2014) miR-195 regulates SIRT1-mediated changes in diabetic retinopathy. Diabetologia 57:1037–1046. https://doi.org/10.1007/s00125-014-3197-9
Musch DC, Gillespie BW, Lichter PR, Niziol LM, Janz NK, Investigators CS (2009) Visual field progression in the collaborative initial glaucoma treatment study: the impact of treatment and other baseline factors. Ophthalmology 116:200–207. https://doi.org/10.1016/j.ophtha.2008.08.051
Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, Dijke T, P (1997) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389:631–635. https://doi.org/10.1038/39369
Nguyen QD, Brown DM, Marcus DM, Boyer DS, Patel S, Feiner L, Gibson A, Sy J, Rundle AC, Hopkins JJ (2012) Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology 119:789–801. https://doi.org/10.1016/j.ophtha.2011.12.039
Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S (2002) Smad7 mediates transforming growth factor-β–induced apoptosis in mesangial cells. Kidney Int 62:1178–1186. https://doi.org/10.1111/j.1523-1755.2002.kid583.x
Osseni A, Ravel-Chapuis A, Belotti E, Scionti I, Gangloff YG, Moncollin V, Mazelin L, Mounier R, Leblanc P, Jasmin BJ, Schaeffer L (2022) Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-beta via Smad3 acetylation. Nat Commun 13:7108. https://doi.org/10.1038/s41467-022-34831-3
Pan F, Hu D, Sun LJ, Bai Q, Wang YS, Hou X (2023) Valproate reduces retinal ganglion cell apoptosis in rats after optic nerve crush. Neural Regen Res 18:1607–1612. https://doi.org/10.4103/1673-5374.357913
Park D, Park H, Kim Y, Kim H, Jeoung D (2014) HDAC3 acts as a negative regulator of angiogenesis. BMB Rep 47:227–232. https://doi.org/10.5483/bmbrep.2014.47.4.128
Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM (2019) Arg-Leu-tyr-glu suppresses retinal endothelial permeability and choroidal neovascularization by inhibiting the VEGF receptor 2 signaling pathway. Biomol Ther (Seoul) 27:474–483. https://doi.org/10.4062/biomolther.2019.041
Park J, Lai MKP, Arumugam TV, Jo DG (2020) O-GlcNAcylation as a therapeutic target for Alzheimer’s disease. Neuromol Med 22:171–193. https://doi.org/10.1007/s12017-019-08584-0
Park J, Lee K, Kim K, Yi S-J (2022) The role of histone modifications: from neurodevelopment to neurodiseases. Signal Transduct Target Ther 7:217. https://doi.org/10.1038/s41392-022-01078-9
Pedro Ferreira J, Pitt B, Zannad F (2021) Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity. Lancet Healthy Longev 2:e371–e379. https://doi.org/10.1016/S2666-7568(21)00061-1
Pelzel HR, Schlamp CL, Nickells RW (2010) Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis. BMC Neurosci 11:62. https://doi.org/10.1186/1471-2202-11-62
Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, Tinman S, Alt FW, Banin E, Cohen HY (2017) Characterization of physiological defects in adult SIRT6-/- mice. PLoS One 12:e0176371. https://doi.org/10.1371/journal.pone.0176371
Pierce EA, Foley ED, Smith LE (1996) Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 114:1219–1228. https://doi.org/10.1001/archopht.1996.01100140419009
Popova EY, Imamura Kawasawa Y, Zhang SS, Barnstable CJ (2021) Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of retinitis pigmentosa. J Neurosci 41:6775–6792. https://doi.org/10.1523/JNEUROSCI.3102-20.2021
Prendes MA, Harris A, Wirostko BM, Gerber AL, Siesky B (2013) The role of transforming growth factor β in glaucoma and the therapeutic implications. Br J Ophthalmol 97:680–686. https://doi.org/10.1136/bjophthalmol-2011-301132
Qi F, Jiang X, Tong T, Chang H, Li RX (2020) MiR-204 inhibits inflammation and cell apoptosis in retinopathy rats with diabetic retinopathy by regulating Bcl-2 and SIRT1 expressions. Eur Rev Med Pharmacol Sci 24:6486–6493. https://doi.org/10.26355/eurrev_202006_21631
Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P, Pili R (2006) Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res 66:8814–8821. https://doi.org/10.1158/0008-5472.CAN-05-4598
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, Macgrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction*. J Biol Chem 281:21745–21754. https://doi.org/10.1074/jbc.M602909200
Qiu M, Wang SY, Singh K, Lin SC (2013) Association between myopia and glaucoma in the United States population. Investig Ophthalmol Vis Sci 54:830–835
Quigley HA, Addicks EM, Green WR, Maumenee AE (1981) Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage. Arch Ophthalmol 99:635–649. https://doi.org/10.1001/archopht.1981.03930010635009
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, **e S, Li D, Gao J, Zhang X, Zhu X, Zhou J (2020) ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev Cell 53:287-299e5. https://doi.org/10.1016/j.devcel.2020.03.010
Ran J, Zhang Y, Zhang S, Li H, Zhang L, Li Q, Qin J, Li D, Sun L, **e S, Zhang X, Liu L, Liu M, Zhou J (2022) Targeting the HDAC6-cilium axis ameliorates the pathological changes associated with retinopathy of prematurity. Adv Sci (Weinh) 9:e2105365. https://doi.org/10.1002/advs.202105365
Richer S, Patel S, Sockanathan S, Ulanski LJ 2nd, Miller L, Podella C (2014) Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients. Nutrients 6:4404–4420. https://doi.org/10.3390/nu6104404
Riggs MG, Whittaker RG, Neumann JR, Ingram VM (1977) n-Butyrate causes histone modification in HeLa and friend erythroleukaemia cells. Nature 268:462–464. https://doi.org/10.1038/268462a0
Rudnicka AR, Mt-Isa S, Owen CG, Cook DG, Ashby D (2006) Variations in primary open-angle glaucoma prevalence by age, gender, and race: a bayesian meta-analysis. Investig Ophthalmol Vis Sci 47:4254–4261
Sabari BR, Zhang D, Allis CD, Zhao Y (2017) Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol 18:90–101. https://doi.org/10.1038/nrm.2016.140
Samardzija M, Corna A, Gomez-Sintes R, Jarboui MA, Armento A, Roger JE, Petridou E, Haq W, Paquet-Durand F, Zrenner E, De La Villa P, Zeck G, Grimm C, Boya P, Ueffing M, Trifunovic D (2021) HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice. Cell Death Differ 28:1317–1332. https://doi.org/10.1038/s41418-020-00653-3
Sancho-Pelluz J, Alavi MV, Sahaboglu A, Kustermann S, Farinelli P, Azadi S, Van Veen T, Romero FJ, Paquet-Durand F, Ekstrom P (2010) Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse. Cell Death Dis 1:e24. https://doi.org/10.1038/cddis.2010.4
Sano H, Namekata K, Kimura A, Shitara H, Guo X, Harada C, Mitamura Y, Harada T (2019) Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma. Cell Death Dis 10:75. https://doi.org/10.1038/s41419-019-1365-z
Santoro F, Botrugno OA, Dal Zuffo R, Pallavicini I, Matthews GM, Cluse L, Barozzi I, Senese S, Fornasari L, Moretti S, Altucci L, Pelicci PG, Chiocca S, Johnstone RW, Minucci S (2013) A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance. Blood 121:3459–3468. https://doi.org/10.1182/blood-2012-10-461988
Sarubbo F, Esteban S, Miralles A, Moranta D (2018) Effects of resveratrol and other polyphenols on Sirt1: relevance to brain function during aging. Curr Neuropharmacol 16:126–136. https://doi.org/10.2174/1570159X15666170703113212
Schmitt HM, Schlamp CL, Nickells RW (2016) Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells. Neurosci Lett 625:11–15. https://doi.org/10.1016/j.neulet.2015.12.012
Sedda S, Franzè E, Bevivino G, Di Giovangiulio M, Rizzo A, Colantoni A, Ortenzi A, Grasso E, Giannelli M, Sica GS, Fantini MC, Monteleone G (2018) Reciprocal regulation between Smad7 and Sirt1 in the gut. Front Immunol 9:1854. https://doi.org/10.3389/fimmu.2018.01854
Seo KS, Park JH, Heo JY, **g K, Han J, Min KN, Kim C, Koh GY, Lim K, Kang GY, Uee Lee J, Yim YH, Shong M, Kwak TH, Kweon GR (2015) SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation. Oncogene 34:1354–1362. https://doi.org/10.1038/onc.2014.76
Sestito R, Madonna S, Scarponi C, Cianfarani F, Failla CM, Cavani A, Girolomoni G, Albanesi C (2011) STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. Faseb J 25:916–927. https://doi.org/10.1096/fj.10-172288
Shan B, Yao TP, Nguyen HT, Zhuo Y, Levy DR, Klingsberg RC, Tao H, Palmer ML, Holder KN, Lasky JA (2008) Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition. J Biol Chem 283:21065–21073. https://doi.org/10.1074/jbc.M802786200
Shen P, Deng X, Chen Z, Ba X, Qin K, Huang Y, Huang Y, Li T, Yan J, Tu S (2021) SIRT1: a potential therapeutic target in autoimmune diseases. Front Immunol 12:779177. https://doi.org/10.3389/fimmu.2021.779177
Silberman DM, Ross K, Sande PH, Kubota S, Ramaswamy S, Apte RS, Mostoslavsky R (2014) SIRT6 is required for normal retinal function. PLoS One 9:e98831. https://doi.org/10.1371/journal.pone.0098831
Simic P, Williams M, Guarente L (2013) SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis. Cell Reports. https://doi.org/10.1016/j.celrep.2013.03.019
Simões-Pires C, Zwick V, Nurisso A, Schenker E, Carrupt PA, Cuendet M (2013) HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Mol Neurodegener 8:7. https://doi.org/10.1186/1750-1326-8-7
Simonsson M, Heldin C-H, Ericsson J, Grönroos E (2005) The balance between acetylation and deacetylation controls Smad7 stability*. J Biol Chem 280:21797–21803. https://doi.org/10.1074/jbc.M503134200
Siwak M, Maślankiewicz M, Nowak-Zduńczyk A, Rozpędek W, Wojtczak R, Szymanek K, Szaflik M, Szaflik J, Szaflik JP, Majsterek I (2018) The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma. Ophthalmic Genet 39:325–331. https://doi.org/10.1080/13816810.2018.1432061
Smith RO, Ninchoji T, Gordon E, Andre H, Dejana E, Vestweber D, Kvanta A, Claesson-Welsh L (2020) Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. Elife. https://doi.org/10.7554/eLife.54056
Stahl A (2020) The diagnosis and treatment of age-related macular degeneration. Dtsch Arztebl Int 117:513–520. https://doi.org/10.3238/arztebl.2020.0513
Sundaramurthi H, Roche SL, Grice GL, Moran A, Dillion ET, Campiani G, Nathan JA, Kennedy BN (2020) Selective histone deacetylase 6 inhibitors restore cone photoreceptor vision or outer segment morphology in zebrafish and mouse models of retinal blindness. Front Cell Dev Biol 8:689. https://doi.org/10.3389/fcell.2020.00689
Suuronen T, Nuutinen T, Ryhanen T, Kaarniranta K, Salminen A (2007) Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. Biochem Biophys Res Commun 357:397–401. https://doi.org/10.1016/j.bbrc.2007.03.135
Tan Y, Fukutomi A, Sun MT, Durkin S, Gilhotra J, Chan WO (2021) Anti-VEGF crunch syndrome in proliferative diabetic retinopathy: a review. Surv Ophthalmol 66:926–932. https://doi.org/10.1016/j.survophthal.2021.03.001
Tang X, Shi L, **e N, Liu Z, Qian M, Meng F, Xu Q, Zhou M, Cao X, Zhu W-G, Liu B (2017) SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. Nat Commun 8:318. https://doi.org/10.1038/s41467-017-00396-9
Tao Y, Jiang P, Liu M, Liu Y, Song L, Wang H (2021) Intravitreal aflibercept partially reverses severe non-proliferative diabetic retinopathy in treatment-naive patients. J Int Med Res 49:300060520985369. https://doi.org/10.1177/0300060520985369
Teo ZL, Tham YC, Yu M, Chee ML, Rim TH, Cheung N, Bikbov MM, Wang YX, Tang Y, Lu Y, Wong IY, Ting DSW, Tan GSW, Jonas JB, Sabanayagam C, Wong TY, Cheng CY (2021) Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology 128:1580–1591. https://doi.org/10.1016/j.ophtha.2021.04.027
Thakur N, Hamidi A, Song J, Itoh S, Bergh A, Heldin CH, Landstrom M (2020) Smad7 enhances TGF-beta-Induced transcription of c-Jun and HDAC6 promoting invasion of prostate cancer cells. iScience 23:101470. https://doi.org/10.1016/j.isci.2020.101470
Tham Y-C, Li X, Wong TY, Quigley HA, Aung T, Cheng C-Y (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121:2081–2090
Thomas CJ, Mirza RG, Gill MK (2021) Age-related macular degeneration. Med Clin North Am 105:473–491. https://doi.org/10.1016/j.mcna.2021.01.003
Thounaojam MC, Jadeja RN, Warren M, Powell FL, Raju R, Gutsaeva D, Khurana S, Martin PM, Bartoli M (2019) MicroRNA-34a (miR-34a) mediates retinal endothelial cell premature senescence through mitochondrial dysfunction and loss of antioxidant activities. Antioxidants 8:328. https://doi.org/10.3390/antiox8090328
Tu AW, Luo K (2007) Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor β response*. J Biol Chem 282:21187–21196. https://doi.org/10.1074/jbc.M700085200
Tu Y, Song E, Wang Z, Ji N, Zhu L, Wang K, Sun H, Zhang Y, Zhu Q, Liu X, Zhu M (2021) Melatonin attenuates oxidative stress and inflammation of Muller cells in diabetic retinopathy via activating the Sirt1 pathway. Biomed Pharmacother 137:111274. https://doi.org/10.1016/j.biopha.2021.111274
Urbich C, Rössig L, Kaluza D, Potente M, Boeckel J-N, Knau A, Diehl F, Geng J-G, Hofmann W-K, Zeiher AM, Dimmeler S (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113:5669–5679. https://doi.org/10.1182/blood-2009-01-196485
Valikodath NG, Chiang MF, Chan RVP (2021) Description and management of retinopathy of prematurity reactivation after intravitreal antivascular endothelial growth factor therapy. Curr Opin Ophthalmol 32:468–474. https://doi.org/10.1097/icu.0000000000000786
Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN (2008) Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase. Proc Nat Acad Sci. https://doi.org/10.1073/pnas.0802857105
Wang X, Abraham S, Mckenzie JG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature 499:306–311. https://doi.org/10.1038/nature12345
Wang P, Du H, Zhou CC, Song J, Liu X, Cao X, Mehta JL, Shi Y, Su DF, Miao CY (2014) Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating notch signalling in endothelial progenitors. Cardiovasc Res 104:477–488. https://doi.org/10.1093/cvr/cvu220
Wang J, Harris A, Prendes MA, Alshawa L, Gross JC, Wentz SM, Rao AB, Kim NJ, Synder A, Siesky B (2017) Targeting transforming growth factor-β signaling in primary open-angle glaucoma. J Glaucoma 26:390–395. https://doi.org/10.1097/ijg.0000000000000627
Weinreb RN, Khaw PT (2004) Primary open-angle glaucoma. Lancet 363:1711–1720. https://doi.org/10.1016/S0140-6736(04)16257-0
Weinreb RN, Aung T, Medeiros FA (2014) The pathophysiology and treatment of glaucoma: a review. JAMA 311:1901–1911. https://doi.org/10.1001/jama.2014.3192
Weinreb RN, Leung CK, Crowston JG, Medeiros FA, Friedman DS, Wiggs JL, Martin KR (2016) Primary open-angle glaucoma. Nat Rev Dis Primers 2:16067. https://doi.org/10.1038/nrdp.2016.67
Wong TY, Cheung CM, Larsen M, Sharma S, Simo R (2016) Diabetic retinopathy. Nat Rev Dis Primers 2:16012. https://doi.org/10.1038/nrdp.2016.12
Wu KY, Kulbay M, Toameh D, Xu AQ, Kalevar A, Tran SD (2023) Retinitis pigmentosa: novel therapeutic targets and drug development. Pharmaceutics. https://doi.org/10.3390/pharmaceutics15020685
**ao Q, Zeng L, Zhang Z, Margariti A, Ali ZA, Channon KM, Xu Q, Hu Y (2006) Sca-1 + progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury. Arterioscler Thromb Vasc Biol 26:2244–2251. https://doi.org/10.1161/01.Atv.0000240251.50215.50
**ao X, Chen M, Xu Y, Huang S, Liang J, Cao Y, Chen H (2020) Sodium butyrate inhibits neovascularization partially via TNXIP/VEGFR2 pathway. Oxid Med Cell Longev. https://doi.org/10.1155/2020/6415671
Yaman D, Takmaz T, Yuksel N, Dincer SA, Sahin FI (2020) Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma. Mol Biol Rep 47:9337–9344. https://doi.org/10.1007/s11033-020-05994-3
Yang XJ, Grégoire S (2005) Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol 25:2873–2884. https://doi.org/10.1128/mcb.25.8.2873-2884.2005
Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, Considine T, Riera T, Suri V, White B, Ellis JL, Vlasuk GP, Loh C (2012) SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One 7:e46364. https://doi.org/10.1371/journal.pone.0046364
Yang X, Cai J, Powell DW, Paladugu H, Kuehn MH, Tezel G (2014) Up-regulation of sirtuins in the glaucomatous human retina. Investig Ophthalmol Vis Sci 55:2398–2398
Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM (2013) HEXIM1 down-regulates hypoxia-inducible factor-1alpha protein stability. Biochem J 456:195–204. https://doi.org/10.1042/BJ20130592
Yoo YG, Kong G, Lee MO (2006) Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. Embo J 25:1231–1241. https://doi.org/10.1038/sj.emboj.7601025
Yoon S, Eom GH (2016) HDAC and HDAC inhibitor: from cancer to cardiovascular diseases. Chonnam Med J 52:1–11. https://doi.org/10.4068/cmj.2016.52.1.1
Yoshida M, Horinouchi S, Beppu T (1995) Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. BioEssays 17:423–430. https://doi.org/10.1002/bies.950170510
Yu N, Chen P, Wang Q, Liang M, Qiu J, Zhou P, Yang M, Yang P, Wu Y, Han X, Ge J, Zhuang J, Yu K (2020) Histone deacetylase inhibitors differentially regulate c-Myc expression in retinoblastoma cells. Oncol Lett 19:460–468. https://doi.org/10.3892/ol.2019.11111
Yuan ZL, Guan YJ, Chatterjee D, Chin YE (2005) Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307:269–273. https://doi.org/10.1126/science.1105166
Yuan H, Li H, Yu P, Fan Q, Zhang X, Huang W, Shen J, Cui Y, Zhou W (2018) Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury. BMC Ophthalmol 18:300. https://doi.org/10.1186/s12886-018-0951-7
Zaidi SaH, Guzman W, Singh S, Mehrotra S, Husain S (2020) Changes in class I and IIb HDACs by δ-opioid in chronic rat glaucoma model. Investig Ophthalmol Vis Sci 61:4–4. https://doi.org/10.1167/iovs.61.14.4
Zecchin A, Pattarini L, Gutierrez MI, Mano M, Mai A, Valente S, Myers MP, Pantano S, Giacca M (2014) Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity. J Mol Cell Biol 6:116–127. https://doi.org/10.1093/jmcb/mju010
Zeng L, **ao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y, Xu Q (2006) HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells. J Cell Biol 174:1059–1069. https://doi.org/10.1083/jcb.200605113
Zhang H, He S, Spee C, Hinton DR (2014) The effects of SIRT1 on hypoxia induced by cobalt chloride in human fetal retinal pigment epithelial cells. Investig Ophthalmol Vis Sci 55:385–385
Zhang L, Du J, Justus S, Hsu CW, Bonet-Ponce L, Wu WH, Tsai YT, Wu WP, Jia Y, Duong JK, Mahajan VB, Lin CS, Wang S, Hurley JB, Tsang SH (2016a) Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest 126:4659–4673. https://doi.org/10.1172/JCI86905
Zhang Y, Wu D, **a F, **an H, Zhu X, Cui H, Huang Z (2016b) Downregulation of HDAC9 inhibits cell proliferation and tumor formation by inducing cell cycle arrest in retinoblastoma. Biochem Biophys Res Commun 473:600–606. https://doi.org/10.1016/j.bbrc.2016.03.129
Zhang M, Jiang N, Chu Y, Postnikova O, Varghese R, Horvath A, Cheema AK, Golestaneh N (2020) Dysregulated metabolic pathways in age-related macular degeneration. Sci Rep 10:2464. https://doi.org/10.1038/s41598-020-59244-4
Zhang J, Li Y, Liu Q, Huang Y, Li R, Wu T, Zhang Z, Zhou J, Huang H, Tang Q, Huang C, Zhao Y, Zhang G, Jiang W, Mo L, Zhang J, **e W, He J (2021) Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells. Hepatology 73:1140–1157. https://doi.org/10.1002/hep.31418
Zhao S, Li T, Li J, Lu Q, Han C, Wang N, Qiu Q, Cao H, Xu X, Chen H, Zheng Z (2016) miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway. Diabetologia 59:644–654. https://doi.org/10.1007/s00125-015-3832-0
Zhao E, Hou J, Ke X, Abbas MN, Kausar S, Zhang L, Cui H (2019) The roles of sirtuin family proteins in cancer progression. Cancers. https://doi.org/10.3390/cancers11121949
Zhao S, Huang Z, Jiang H, **u J, Zhang L, Long Q, Yang Y, Yu L, Lu L, Gu H (2022) Sirtuin 1 induces choroidal neovascularization and triggers age-related macular degeneration by promoting LCN2 through SOX9 deacetylation. Oxid Med Cell Longev. https://doi.org/10.1155/2022/1671438
Zhong Q, Kowluru RA (2010) Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem 110:1306–1313. https://doi.org/10.1002/jcb.22644
Zhong H, May MJ, Jimi E, Ghosh S (2002) The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 9:625–636. https://doi.org/10.1016/s1097-2765(02)00477-x
Zhong L, D’urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140:280–293. https://doi.org/10.1016/j.cell.2009.12.041
Zhou J, Wu A, Yu X, Zhu J, Dai H (2017) SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway. Oncol Rep 38:1059–1066. https://doi.org/10.3892/or.2017.5753
Zhou L, Ng DS, Yam JC, Chen LJ, Tham CC, Pang CP, Chu WK (2022) Post-translational modifications on the retinoblastoma protein. J Biomed Sci 29:33. https://doi.org/10.1186/s12929-022-00818-x
Zimmermann S, Kiefer F, Prudenziati M, Spiller C, Hansen J, Floss T, Wurst W, Minucci S, Göttlicher M (2007) Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice. Cancer Res 67:9047–9054. https://doi.org/10.1158/0008-5472.Can-07-0312
Zin A, Gole GA (2013) Retinopathy of prematurity-incidence today. Clin Perinatol 40:185–200. https://doi.org/10.1016/j.clp.2013.02.001
Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM (2018) Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6. J Neurochem 144:128–138. https://doi.org/10.1111/jnc.14243
Zou H, Shan C, Ma L, Liu J, Yang N, Zhao J (2020) Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. PeerJ 8:e10136. https://doi.org/10.7717/peerj.10136
Funding
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF-2019R1A2C3011422, NRF-2019R1A5A2027340). This work was also supported by a grant from the Ministry of Oceans and Fisheries’ R&D project, Korea (1525011845).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Jae Hyun Jun is an employee of Chong Kun Dang Pharmaceutical Co. The other authors have no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Jun, J.H., Kim, JS., Palomera, L.F. et al. Dysregulation of histone deacetylases in ocular diseases. Arch. Pharm. Res. 47, 20–39 (2024). https://doi.org/10.1007/s12272-023-01482-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12272-023-01482-x