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S-100 Protein-Negative Secretory Breast Carcinoma: Case Report of a Rare Entity

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Abstract

Secretory breast carcinoma represents a rare subtype within basal-like tumours of the breast, having an excellent prognosis, in stark contrast with other basal-like tumours. These tumours are typically ER, PR and HER-2 negative, and S-100 positive. Recurrences are far and few, and treatment is predominantly surgical. We report here a unique case of S-100 marker-negative secretory breast carcinoma in an adult female with a clinical presentation and histo-morphological features otherwise typical of secretory breast carcinomas. This case was managed with radical surgery and adjuvant chemotherapy. Secretory breast carcinomas are unique among basal-like tumours in having an excellent prognosis. They may however be part of a larger spectrum of secretory carcinomas across several glandular organs, with the recently discovered ETV6-NTRK3 fusion gene as a common, recurring mutation. The significance of absence of S-100 staining is not yet clear; however, it may portend a worse prognosis, warranting more aggressive therapy.

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Authors and Affiliations

  1. Department of General Surgery, Seth Gordhandas Sunderdas Medical College & King Edward Memorial Hospital, Parel, Mumbai, India

    Shilpa A. Rao & Sridhar Suresh

  2. Seth Gordhandas Sunderdas Medical College & King Edward Memorial Hospital, Parel, Mumbai, India

    Sridhar Suresh & Khizer Imtiyaz

  3. Department of Surgical Gastroenterology, Seth Gordhandas Sunderdas Medical College & King Edward Memorial Hospital, Parel, Mumbai, India

    Aditya Kunte

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  1. Shilpa A. Rao
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  2. Sridhar Suresh
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Correspondence to Sridhar Suresh.

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Rao, S.A., Suresh, S., Imtiyaz, K. et al. S-100 Protein-Negative Secretory Breast Carcinoma: Case Report of a Rare Entity. Indian J Surg 84, 1315–1319 (2022). https://doi.org/10.1007/s12262-021-03218-x

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  • DOI: https://doi.org/10.1007/s12262-021-03218-x

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