Abstract
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
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The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
References
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Farzaneh, M., Nasrolahi, A., Ghaedrahmati, F. et al. Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells. Clin Transl Oncol 25, 2015–2042 (2023). https://doi.org/10.1007/s12094-023-03110-y
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DOI: https://doi.org/10.1007/s12094-023-03110-y