Abstract
Giant cell tumor (GCT) of bone is a rare, benign, osteolytic neoplasm that most commonly occurs in early adulthood and often involves the long bones of the body. Although GCT largely affects the epiphyses of long bones, several reports of GCT involvement of the cranial and facial bones exist in the literature. In addition to reviewing other reported cases of GCT of the lateral skull base in the literature, the authors report here on the clinical presentation, radiographic findings, and management of a patient found to have a GCT of the squamous part of temporal bone invading the middle ear and infratemporal fossae, which was treated by en bloc resection of the lateral skull base.
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References
Chen LK, Su CT, Tsai YF et al (2001) Giant cell tumor of the bone: radiography, CT, MRI, and angiography finding. Chin J Radiol. 26:61–67
Tsai Y-F, Chen L-K, Su C-T, Lee C-C, Wai C-P, Chen S-Y (2000) Giant cell tumor of the skull base: a case report. Chin J Radiol 25:223–227
Zorlu F, Selek U, Soylemezoglu F, Oge K (2006) Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. J Neurooncol 76:149–152
Venkatesh MD, Vijaya N, Girish N, Galagali JR (2012) Giant cell tumor of temporal bone: A case report. Med J Armed Forces India 68:392–394
Iizuka T et al (2012) Giant cell tumor of the temporal bone with direct invasion into the middle ear and skull base: a case report. Case Rep Otolaryngol 2012:4
Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT, Kransdorf MJ (2001) From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics 21:1283–1309
Werner M (2006) Giant cell tumour of bone: morphological, biological and histogenetical aspects. Int Orthop 30(06):484–489
Shen Y, Ma C, Wang L, Li J, Wu Y, Sun J (2016) Surgical management of giant cell tumors in temporomandibular joint region involving lateral skull base: a multidisciplinary approach. J Oral Maxillofac Surg 74(11):2295–2311
Freeman JL, Oushy S, Schowinsky J, Sillau S, Youssef AS (2016) Invasive giant cell tumor of the lateral skull base: a systematic review, metaanalysis, and case illustration. World Neurosurg 96:47–57
Roberts DS, Faquin WC, Deschler DG (2010) Giant cell tumors of the temporal bone and infratemporal fossa: a case report and review of the literature. Laryngoscope 120(Suppl 4):S18
Mohamed A, Omi E, Honda K, Suzuki S, Sato T, Fukui N, Ishikawa K (2014) Giant cell tumor of the temporal bone invading into the pterygoid muscle through the temporomandibular joint. J Neurol Surg Rep 75(01):e136–e140. https://doi.org/10.1055/s-0034-1376428
Prasad SC, Piccirillo E, Nuseir A et al (2014) Giant cell tumors of the skull base: case series and current concepts. Audiol Neurootol 19(01):12–21
Zhang Z, Xu J, Yao Y et al (2013) Giant cell tumors of the skull: a series of 18 cases and review of the literature. J Neurooncol 115(03):437–444
Malone S, O’Sullivan B, Catton C, Bell R, Fornasier V, Davis A (1995) Long term follow-up of efficacy and safety of megavoltage radiotherapy in high-risk giant cell tumors of bone. Int J Radiat Oncol Biol Phys 33(03):689–694
Roeder F, Timke C, Zwicker F et al (2010) Intensity modulated radiotherapy (IMRT) in benign giant cell tumors–a single institution case series and a short review of the literature. Radiat Oncol 5:18. https://doi.org/10.1186/1748-717X-5-18
Kim IY, Jung S, Jung TY et al (2012) Gamma knife radiosurgery for giant cell tumor of the petrous bone. Clin Neurol Neurosurg 114(02):185–189
Xu SF, Adams B, Yu XC, Xu M (2013) Denosumab and giant cell tumour of bone-a review and future management considerations. Curr Oncol 20(05):e442–e447
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Gupta, N., Rubina, Rahman, A. et al. Giant Cell Tumor of the Temporal Bone with Direct Invasion into the Middle Ear and Skull Base: A Case Report. Indian J Otolaryngol Head Neck Surg 76, 2890–2894 (2024). https://doi.org/10.1007/s12070-024-04550-w
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DOI: https://doi.org/10.1007/s12070-024-04550-w