Abstract
Totally endoscopic coronary artery bypass (TECAB) surgery can exclusively be undertaken with the aid of operative robots. In the past two decades, surgical remote manipulator systems—predominantly the daVinci® devices—have brought us the reality of endoscopic internal mammary artery harvesting and coronary bypass anastomoses via minimally invasive thoracic port access. Single up to quadruple TECAB interventions are recently feasible; the procedure can be delivered either as beating heart applying endoscopic vacuum stabilizer or under cardioplegic arrest on heart-lung machine. Significant surgical team learning curves are involved in a stepwise development of these complex procedures, including intense dry- and wet-lab trainings, endoscopic internal mammary artery harvesting and manual coronary anastomosis building through a thoracotomy. Increasing number of papers have been published regarding clinical TECAB series in the past decade. In arrested heart TECAB procedures on cardiopulmonary bypass, the conversion rate from port access to larger thoracic incision measures 15.1% and no perioperative mortality is observed in published records. Stroke, kidney failure and atrial fibrillation rates stay at 0.6, 0.4 and 12.9%, respectively. Analysis of beating heart TECAB procedures revealed a conversion rate of 15.3%, perioperative mortality 0.4%, stroke 0.3%, kidney failure 0.6% and atrial fibrillation 9.2%. Additionally, due to the obviously smaller surgical trauma, a remarkable fast return to normal daily activities can be demonstrated in clinical series of robotic assisted coronary bypass surgery. Short-term freedom of major adverse cardiac and cerebral events (MACCE) stays over 90%. Long-term studies reveal 5-year freedom of MACCE in the 75.2 to 83.1% range. Nowadays, total endoscopic coronary artery bypass grafting is a feasible and reproducible surgical method. Advanced hybrid coronary interventions offer complex multivessel TECAB with support of percutaneous coronary interventions (PCI). Combination of the above techniques widens the spectrum of minimally invasive therapeutic solutions concerning multivessel procedure including bilateral internal mammary grafts and drug-eluting stents.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12055-017-0604-0/MediaObjects/12055_2017_604_Fig1_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12055-017-0604-0/MediaObjects/12055_2017_604_Fig2_HTML.gif)
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs12055-017-0604-0/MediaObjects/12055_2017_604_Fig3_HTML.gif)
Similar content being viewed by others
References
Stevens J, Burdon T, Siegel L, et al. Port-access coronary artery bypass with cardioplegic arrest: acute and chronic canine studies. Ann Thorac Surg. 1996;62:435–41.
Loulmet D, Carpentier A, d’Attellis N, et al. Endoscopic coronary artery bypass grafting with the aid of robotic assisted instruments. J Thorac Cardiovasc Surg. 1999;118:4–10.
Lehr EJ, Grigore A, Reicher B, et al. Dual console robotic system to teach beating heart total endoscopic coronary artery bypass grafting: a video presentation. Interact Cardiovasc Thorac Surg. 2010;8:S113–4.
Argenziano M, Katz M, Bonatti J, et al. Results of the prospective multicenter trial of robotically assisted totally endoscopic coronary artery bypass grafting. Ann Thorac Surg. 2006;81:1666–74.
Bonatti J, Schachner T, Bernecker O, Chevtchik O, Bonaros N, Ott H, et al. Robotic totally endoscopic coronary artery bypass: program development and learning curve issues. J Thorac Cardiovasc Surg. 2004;127:504–10.
Balkhy HH, Nathan S, Arnsdorf SE, Krienbring DJ. Right internal mammary use in 140 robotic totally endoscopic coronary bypass cases: toward multiarterial grafting. Innovations. 2017;12:9–14.
Falk V, Diegeler A, Walther T, et al. Total endoscopic computer enhanced coronary artery bypass grafting. Eur J Cardiothorac Surg. 2000;17:38–45.
Dogan S, Aybek T, Andressen E, et al. Totally endoscopic coronary artery bypass grafting on cardiopulmonary bypass with robotically enhanced telemanipulation: report of forty-five cases. J Thorac Cardiovasc Surg. 2002;123:1125–31.
Reuthebuch O, Comber M, Grünenfelder J, Zünd G, Turina M. Experiences in robotically enhanced IMA-preparation as initial step towards totally endoscopic coronary artery bypass grafting. Cardiovasc Surg. 2003;11:483–7.
Kiaii B, McClure RS, Stitt L, Rayman R, Dobkowski WB, Jablonsky G, et al. Prospective angiographic comparison of direct, endoscopic, and telesurgical approaches to harvesting the internal thoracic artery. Ann Thorac Surg. 2006;82:624–8.
Oehlinger A, Bonaros N, Schachner T, et al. Robotic endoscopic left internal mammary artery harvesting: what have we learned after 100 cases? Ann Thorac Surg. 2007;83:1030–4.
Cheng N, Gao C, Yang M, Wu Y, Wang G, **ao C. Analysis of the learning curve for beating heart, totally endoscopic, coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2014;148:1832–6.
Srivastava S, Barrera R, Quismundo S. One hundred sixty-four consecutive beating heart totally endoscopic coronary artery bypass cases without intraoperative conversion. Ann Thorac Surg. 2012;94:1463–8.
Bayramoglu Z, Caynak B, Ezelsoy M, Oral K, Sagbas E, Akpınar B. Angiographic evaluation of graft patency in robotic-assisted coronary artery bypass surgery: 8 year follow-up. Int J Med Robot. 2014;10:121–7.
Hemli JM, Henn LW, Panetta CR, et al. Defining the learning curve for robotic-assisted endoscopic harvesting of the left internal mammary artery. Innovations. 2013;8:353–8.
Bonatti J, Schachner T, Bonaros N, et al. Technical challenges in totally endoscopic robotic coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2006;131:146–53.
Derose JJ, Balaram SK, Ro C, et al. Mid-term results and patient perceptions of robotically-assisted coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2005;4:406–11.
Subramanian VA, Patel NU, Patel NC, Loulmet DF. Robotic assisted multivessel minimally invasive direct coronary artery bypass with port-access stabilization and cardiac positioning: paving the way for outpatient coronary surgery? Ann Thorac Surg. 2005;79:1590–6.
Daniel WT, Liberman HA, Kilgo P, et al. The impact of clopidogrel therapy on postoperative bleeding after robotic-assisted coronary artery bypass surgery. Eur J Cardiothorac Surg. 2014;46:8–13.
Turner WF, Sloan JH. Robotic-assisted coronary artery bypass on a beating heart: initial experience and implications for the future. Ann Thorac Surg. 2006;82:790–4.
Srivastava S, Gadasalli S, Agusala M, et al. Use of bilateral internal thoracic arteries in CABG through lateral thoracotomy with robotic assistance in 150 patients. Ann Thorac Surg. 2006;81:800–6.
Kon ZN, Brown EN, Tran R, et al. Simultaneous hybrid coronary revascularization reduces postoperative morbidity compared with results from conventional off-pump coronary artery bypass. J Thorac Cardiovasc Surg. 2008;135:367–75.
Poston RS, Tran R, Collins M, et al. Comparison of economic and patient outcomes with minimally invasive versus traditional off-pump coronary artery bypass grafting techniques. Ann Surg. 2008;248:638–46.
Halkos ME, Liberman HA, Devireddy C, et al. Early clinical and angiographic outcomes after robotic-assisted coronary artery bypass surgery. J Thorac Cardiovasc Surg. 2014;147:179–85.
Fujita T, Hata H, Shimahara Y, Sato S, Kobayashi J. Initial experience with internal mammary artery harvesting with the da Vinci Surgical System for minimally invasive direct coronary artery bypass. Surg Today. 2014;44:2281–6.
Yang M, Wu Y, Wang G, **ao C, Zhang H, Gao C. Robotic total arterial off-pump coronary artery bypass grafting: seven-year single-center experience and long-term follow-up of graft patency. Ann Thorac Surg. 2015;100:1367–73.
Bonatti J, Alfadlhi J, Schachner T, Bonaros N, Rützler E, Laufer G. Do manual assisting maneuvers increase speed and technical performance in robotically sutured coronary bypass graft anastomoses? Surg Endosc. 2007;21:1715–8.
Bolton JW, Connally JE. Results of a phase one study on robotically assisted myocardial revascularization on the beating heart. Ann Thorac Surg. 2004;78:154–8.
Schachner T, Bonaros N, Ruetzler E, et al. Myocardial enzyme release in totally endoscopic coronary artery bypass grafting on the arrested heart. J Thorac Cardiovasc Surg. 2007;134:1006–11.
Bonatti J, Schachner T, Bonaros N, et al. Robotic totally endoscopic double-vessel bypass grafting: a further step toward closed-chest surgical treatment of multivessel coronary artery disease. Heart Surg Forum. 2007;10:E239–42.
Bonatti J, Rehman A, Schwartz K, et al. Robotic totally endoscopic triple coronary artery bypass grafting on the arrested heart: report of the first successful clinical case. Heart Surg Forum. 2010;13:E394–6.
Bonatti J, Schachner T, Bonaros N, Laufer G. A new exposure technique for the circumflex coronary artery system in robotic totally endoscopic coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2006;5:279–81.
Falk V, Diegeler A, Walther T, Jacobs S, Raumans J, Mohr FW. Total endoscopic off-pump coronary artery bypass grafting. Heart Surg Forum. 2000;3:29–31.
de Canniere D, Wimmer-Greinecker G, Cichon R, et al. Feasibility, safety, and efficacy of totally endoscopic coronary artery bypass grafting: multicenter European experience. J Thorac Cardiovasc Surg. 2007;134:710–6.
Bonatti J, Schachner T, Bonaros N, et al. Effectiveness and safety of total endoscopic left internal mammary artery bypass graft to the left anterior descending artery. Am J Cardiol. 2009;104:1684–88.
Zaouter C, Imbault J, Labrousse L, et al. Association of robotic totally endoscopic coronary artery bypass graft surgery associated with a preliminary cardiac enhanced recovery after surgery program: a retrospective analysis. J Cardiothorac Vasc Anesth. 2015;29:1489–97.
Weidinger F, Schachner T, Bonaros N, et al. Predictors and consequences of postoperative atrial fibrillation following robotic totally endoscopic coronary bypass surgery. Eur J Cardiothorac Surg. 2014;45:318–22.
Shroyer AL, Grover FL, Hattler B, et al. On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med. 2009;361:1827–37.
Kozora E, Kongs S, Collins JF, et al. Cognitive outcomes after on- versus off-pump coronary artery bypass surgery. Ann Thorac Surg. 2010;90:1134–41.
Kappert U, Cichon R, Gulielmos V, et al. Robotic-enhanced Dresden technique for minimally invasive bilateral internal mammary artery grafting. Heart Surg Forum. 2000;3:319–21.
Boyd WD, Rayman R, Desai ND, et al. Closed-chest coronary artery bypass grafting on the beating heart with the use of a computer-enhanced surgical robotic system. J Thorac Cardiovasc Surg. 2000;120:807–9.
Loisance DY, Nakashima K, Kirsch M. Computer-assisted coronary surgery: lessons from an initial experience. Interact Cardiovasc Thorac Surg. 2005;4:398–401.
Srivastava S, Gadasalli S, Agusala M, et al. Robotically assisted beating heart totally endoscopic coronary artery bypass (TECAB). Is there a future? Innovations. 2008;3:52–8.
Srivastava S, Gadasalli S, Agusala M, et al. Beating heart totally endoscopic coronary artery bypass. Ann Thorac Surg. 2010;89:1873–80.
Balkhy HH, Wann LS, Krienbring D, Arnsdorf SE. Integrating coronary anastomotic connectors and robotics toward a totally endoscopic beating heart approach: review of 120 cases. Ann Thorac Surg. 2011;92:821–7.
Dhawan R, Roberts JD, Wroblewski K, Katz JA, Raman J, Chaney MA. Multivessel beating heart robotic myocardial revascularization increases morbidity and mortality. J Thorac Cardiovasc Surg. 2012;143:1056–61.
Bonatti J, Garcia J, Rehman A, et al. On-pump beating-heart with axillary artery perfusion: a solution for robotic totally endoscopic coronary artery bypass grafting? Heart Surg Forum. 2009;12:E131–3.
Patel NC, Patel NU, Loulmet DF, McCabe JC, Subramanian VA. Emergency conversion to cardiopulmonary bypass during attempted off-pump revascularization results in increased morbidity and mortality. J Thorac Cardiovasc Surg. 2004;128:655–61.
Lehr EJ, Odonkor P, Reyes P, Bonatti J. Minimized extracorporeal circulation for the robotic totally endoscopic coronary artery bypass grafting hybrid procedure. Can J Cardiol. 2010;26:286–7.
Jegaden O, Wautot F, Sassard T, et al. Is there an optimal minimally invasive technique for left anterior descending coronary artery bypass? J Cardiothorac Surg. 2011;6:37.
Kappert U, Cichon R, Tugtekin SM, Schueler S. Closed chest coronary artery bypass on the beating heart. Heart Surg Forum. 2001;4:89–90.
Schachner T, Bonaros N, Wiedemann D, et al. Training surgeons to perform robotically assisted totally endoscopic coronary surgery. Ann Thorac Surg. 2009;88:523–7.
Katz MR, Van Praet F, de Canniere D, et al. Integrated coronary revascularization: percutaneous coronary intervention plus robotic totally endoscopic coronary artery bypass. Circulation. 2006;114:473–I476.
Bonatti J, Schachner T, Bonaros N, et al. Treatment of double vessel coronary artery disease by totally endoscopic bypass surgery and drug-eluting stent placement in one simultaneous hybrid session. Heart Surg Forum. 2005;8:E284–6.
Jansens JL, De Croly P, De Cannière D. Robotic hybrid procedure and triple-vessel disease. J Card Surg. 2009;24:449–50.
Bonatti J, Lehr E, Vesely MR, Friedrich G, Bonaros N, Zimrin D. Hybrid coronary revascularization: which patients? When? How? Curr Opin Cardiol. 2010;25:568–74.
Bonatti JO, Zimrin D, Lehr EJ, et al. Hybrid coronary revascularisation using robotic totally endoscopic surgery; perioperative outcomes and 5-year results. Ann Thorac Surg. 2012;94:1920–6.
Srivastava MC, Vesely MR, Lee JD, et al. Robotically assisted hybrid coronary revascularisation: does sequence of intervention matter? Innovations. 2013;8:177–83.
Bonaros N, Schachner T, Wiedemann D, et al. Quality of life improvement after robotically assisted coronary artery bypass grafting. Cardiology. 2009;114:59–66.
Kappert U, Tugtekin SM, Cichon R, Braun M, Matschke K. Robotic totally endoscopic coronary artery bypass: a word of caution implicated by a five-year follow-up. J Thorac Cardiovasc Surg. 2008;135:857–62.
Currie ME, Romsa J, Fox SA, et al. Long-term angiographic follow-up of robotic-assisted coronary artery revascularization. Ann Thorac Surg. 2012;93:1426–31.
Bonaros N, Schachner T, Lehr E, et al. Five hundred cases of robotic totally endoscopic coronary artery bypass grafting: predictors of success and safety. Ann Thorac Surg. 2013;95:803–12.
Hemli JM, Darla LS, Panetta CR, Jennings J, Subramanian VA, Patel NC. Does body mass index affect outcomes in robotic-assisted coronary artery bypass procedures? Innovations. 2012;7:350–3.
Wiedemann D, Schachner T, Bonaros N, et al. Robotic totally endoscopic coronary artery bypass grafting in men and women: are there sex differences in outcome? Ann Thorac Surg. 2013;96:1643–7.
Serruys PW, Ong AT, van Herwerden LA, et al. Five-year outcomes after coronary stenting versus bypass surgery for the treatment of multivessel disease: the final analysis of the Arterial Revascularization Therapies Study (ARTS) randomized trial. J Am Coll Cardiol. 2005;46:575–81.
Serruys PW, Morice M, Kappetein AP, et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med. 2009;360:961–72.
Cao C, Indraratna P, Doyle M, et al. A systematic review on robotic coronary artery bypass graft surgery. Ann Cardiothorac Surg. 2016;5:530–43.
Seco M, Edelman JJ, Yan TD, Wilson MK, Bannon PG, Vallely MP. Systematic review of robotic-assisted, totally endoscopic coronary artery bypass grafting. Ann Cardiothorac Surg. 2013;2:408–18.
Canale LS, Mick S, Mihaljevic T, Nair R, Bonatti J. Robotically assisted totally endoscopic coronary artery bypass surgery. J Thorac Dis. 2013;5:641–9.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
This review article summarizes and analyses outcomes of several robot-assisted TECAB work groups, utilizing data from current medical literature. Therefore, provision of ethical clearance for publications of third parties is not applicable, albeit we assume that the reviewed papers completely fulfilled the above commitment at the original article submissions.
This review article is not directly involved in basic science and/or clinical research; hence, patient or animal rights are not breached; possession of informed consent is not applicable as well.
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Göbölös, L., Ramahi, J., Obeso, A. et al. Robot-assisted totally endoscopic coronary bypass surgery. Indian J Thorac Cardiovasc Surg 34 (Suppl 2), 94–104 (2018). https://doi.org/10.1007/s12055-017-0604-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12055-017-0604-0