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Recycled Pb/C-catalyzed one-pot synthesis of 1-carbonyl-1H-indoles from 2-iodoanilines and calcium carbide

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Abstract

A series of 1-carbonyl-1H-indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by recyclable10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost calcium carbide, an easy-to-handle acetylene source, and recyclable Pb/C catalysts.

Graphic abstract

The synthesis of a series of 1-carbonyl-1H-indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by 10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost feedstock, an easy-to-handle acetylene source, and recyclable Pb/C catalysts.

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The author gratefully acknowledges financial support from Hebei Chemical & Pharmaceutical College.

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  1. Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang, 050026, Hebei, People’s Republic of China

    Zhicai Zhao

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Zhao, Z. Recycled Pb/C-catalyzed one-pot synthesis of 1-carbonyl-1H-indoles from 2-iodoanilines and calcium carbide. J Chem Sci 136, 52 (2024). https://doi.org/10.1007/s12039-024-02286-2

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