Abstract
The nonsteroidal anti-inflammatory drug (NSAID), ibuprofen (IBU) anion, was intercalated into the layered zinc hydroxide (LZH) to form a new organic–inorganic nanohybrid. Then, IBU–LZH nanohybrid was dispersed into chitosan for the formation of the nanocomposite. The IBU–LZH nanohybrid was characterized by powder X-ray diffraction (PXRD) to study intercalation, scanning electron microscopy (SEM) for the investigation of surface morphology, Fourier transform infrared (FTIR) spectrophotometer to study the chemical interactions and thermal gravimetric analysis/derivative thermogravimetric analysis (TGA/DTG) for understanding the thermal stability. The PXRD patterns showed that the IBU was successfully intercalated into the interlay space of LZHs as monolayers and the basal spacing of LZH increased from 9.57 to 19.54 Å. The FTIR analyses confirmed the formation of the host–guest nanohybrid. The DTG studies revealed that the thermal stability of IBU was increased after the intercalation into LZH. The in vitro release study of IBU from IBU–LZH and IBU–LZH/chitosan nanocomposite was investigated in phosphate buffer saline (PBS) solution of pH 4.8 and 7.4. The drug release from the LZH was studied by ultraviolet–visible (UV–vis) spectroscopy.
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References
Sanchez C, Julian B, Belleville P and Popall M 2005 J. Mater. Chem. 15 3559
Choy J H, Kwon S J and Park G S 1998 Science 280 1589
Hussein M Z, Ghotbi M Y, Yahaya A H and Rahman M Z A 2009 Mater. Chem. Phys. 113 491
Kasai A and Fujihara S 2006 Inorg. Chem. 45 415
Yeganeh Ghotbi M, Bagheri N and Sadrnezhaad S K 2011 J. Colloid. Interface Sci. 362 89
Newman S P and Jones W 1999 J. Solid State Chem. 148 26
Morioka H, Tagaya H, Kasaru M, Kadokawa J and Chiba K 1999 Inorg. Chem. 38 4211
Seida Y and Nakano Y 2002 Water Res. 36 1306
Kwon S J and Choy J H 2003 Inorg. Chem. 42 8134
Altuntasoglu O, Matsuda Y, Ida S and Matsumoto Y 2010 Chem. Mater. 22 3158
Zhao L, Miao J, Wang H, Ishikawa Y and Feng Q 2011 Chin. J. Chem. 29 1837
Arizaga G G C, Satyanarayana K G and Wypych F 2007 Solid State Ion. 178 1143
Barahuie F, Hussein M Z, Arulselvan P, Fakurazi S and Zainal Z 2013 Sci. Adv. Mater. 5 1983
Choy J H, Shin J, Lim S Y, Oh J M, Oh M H and Oh H 2010 J. Food Sci. 75 N63
Hussein M Z, Al Ali S H, Zainal Z and Hakim M N 2011 Int. J. Nanomed. 6 1373
Nabipour H and Hosaini Sadr M 2015 J. Porous Mater. 22 447
Nabipour H, Hosaini Sadr M and Thomas N 2015 J. Exp. Nanosci. doi:10.1080/17458080.2014.998301
Latip A F A, Hussein M Z, Stanslas J, Choon W C and Adnan R 2013 Chem. Cent. J. 7 119
Barahuie F, Hussein M Z, Abd Gani S H, Fakurazi S H and Zainal Z 2014 Int. J. Nanomed. 9 3137
He J, Wei M, Li B, Kang Y, Evans D G and Duan X 2006 Struct. Bond. 119 89
Machovsky M, Kuritka K I, Sedlak J and Pastorek M 2013 Mater. Res. Bull. 48 4002
Ishikawa T, Matsumoto K, Kandori K and Nakayama T 2007 Colloids Surf. A: Physicochem. Eng. Asp. 293 135
Biswick T, Park D H and Choy J H 2012 J. Phys. Chem. Solids 73 1510
Bashi A M, Hussein M Z, Zainal Z and Tichit D 2013 J. Solid State Chem. 203 19
Bashi A M, Haddawi S M and Mezaal M A 2013 Arab., J. Sci. Eng. 38 1663
Regula J, Butruk E, Dekkers C P, de Boer S Y, Raps D, Simon L, Terjung A, Thomas K B, Lühmann R and Fischer R 2006 Am. J. Gastroenterol. 101 1747
Thompson M and Percy J S 1966 Br. Med. J. 1 80
Harth M and Bondy D C 1969 Can. Med. Assoc. J. 101 311
Roth S H 1985 Rheumatic therapeutics (New York: McGraw-Hill)
Amidon G L, Lennernäs H, Shah V P and Crison J R 1995 Pharm. Res. 12 413
Xu L, Li S M and Sunada H 2007 Chem. Pharm. Bull. 55 1545
Patrick Stahly G, McKenzie A T, Andres M C, Russell C A, Byrn S R and Johnson P 1997 J. Pharm. Sci. 86 970
Gunawan P and Xu R 2008 J. Pharm. Sci. 97 4367
Ramukutty S and Ramachandran E 2012 Cryst. Res. Technol. 47 31
Depan D, Saikia L and Singh P 2010 Macromol. Symp. 287 80
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The financial support from Azarbaijan Shahid Madani University Research Council and International Imam Khomeini University is greatly appreciated.
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NABIPOUR, H., SADR, M.H. Layered zinc hydroxide–ibuprofen nanohybrids: synthesis and characterization. Bull Mater Sci 38, 1561–1567 (2015). https://doi.org/10.1007/s12034-015-0971-3
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DOI: https://doi.org/10.1007/s12034-015-0971-3