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Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients

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Abstract

The TNF -238G/A (rs361525) and -308G/A (rs1800629) polymorphisms have consistently been associated with systemic lupus erythematosus (SLE) in several populations; however, these findings have not been verified in all populations. Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population. Our study included 442 patients with SLE and 495 controls. For genoty**, we used the TaqMan 5′ allele discrimination assay. The TNF -238G/A and -1031T/C polymorphisms were associated with SLE susceptibility (odds ratio (OR) 2.1, p = 0.0005 and OR 1.4, p = 0.003, respectively). Gender stratification showed a strong association between TNF -238G/A and SLE in women (OR 2.2, p = 0.00006), while TNF -1031T/C had an OR of 1.5 (p = 0.007). With regard to the TNF -376G/A polymorphism, this also showed association with SLE susceptibility (OR 1.95, p = 0.036) and LN (OR 3.5, p = 0.01). In conclusion, our study provides the first demonstration of association between the TNF -376G/A polymorphism and SLE and LN susceptibility. In addition, our study is the second documenting an association of TNF -1031T/C with SLE susceptibility. We also observed a strong association between TNF -238G/A and SLE susceptibility. The TNF 308G/A polymorphism was not associated with SLE or LN.

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Funding

This study was supported by a grant of the Consejo Nacional de Ciencia y Tecnología de México (CONACyT) (FOSISS: project no. 233107).

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Authors and Affiliations

  1. Unidad de Investigación en Investigación en Enfermedades Metabólicas y Endócrinas, Hospital Juárez de México, Mexico City, Mexico

    Julian Ramírez-Bello & Daniel Cadena-Sandoval

  2. Instituto Politécnico Nacional, Gustavo A. Madero, Magdalena de Las Salinas, 07760, Mexico City, Mexico

    Julian Ramírez-Bello

  3. Programa de Doctorado de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico

    Daniel Cadena-Sandoval

  4. Laboratorio de Oncología Molecular, Unidad de Diferenciacón Celular y Cáncer, FES-Zaragoza, UNAM, Mexico City, Mexico

    Jorge Flavio Mendoza-Rincón

  5. Servicio de Reumatología, Hospital Juárez de México, Mexico City, Mexico

    Rosa Elda Barbosa-Cobos

  6. Departamento de Inmunología, Instituto Nacional de Cardiología, Mexico City, Mexico

    Fausto Sánchez-Muñoz & Luis M Amezcua-Guerra

  7. Laboratorio de Diagnóstico Molecular y Genética, Hospital Juárez de México, Mexico City, Mexico

    Mónica Sierra-Martínez

  8. Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico

    Silvia Jiménez-Morales

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  1. Julian Ramírez-Bello
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  2. Daniel Cadena-Sandoval
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  6. Luis M Amezcua-Guerra
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  7. Mónica Sierra-Martínez
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  8. Silvia Jiménez-Morales
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Correspondence to Julian Ramírez-Bello.

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Ramírez-Bello, J., Cadena-Sandoval, D., Mendoza-Rincón, J.F. et al. Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients. Immunol Res 66, 348–354 (2018). https://doi.org/10.1007/s12026-018-8993-8

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