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Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae

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Abstract

Cadmium (Cd) is a toxic heavy metal mainly originating from industrial activities and causes environmental pollution. To better understand its toxicity and pollution remediation, we must understand the effects of Cd on living beings. Saccharomyces cerevisiae (budding yeast) is an eukaryotic unicellular model organism. It has provided much scientific knowledge about cellular and molecular biology in addition to its economic benefits. Effects associated with copper and zinc, sulfur and selenium metabolism, calcium (Ca2+) balance/signaling, and structure of phospholipids as a result of exposure to cadmium have been evaluated. In yeast as a result of cadmium stress, “mitogen-activated protein kinase,” “high osmolarity glycerol,” and “cell wall integrity” pathways have been reported to activate different signaling pathways. In addition, abnormalities and changes in protein structure, ribosomes, cell cycle disruption, and reactive oxygen species (ROS) following cadmium cytotoxicity have also been detailed. Moreover, the key OLE1 gene that encodes for delta-9 FA desaturase in relation to cadmium toxicity has been discussed in more detail. Kee** all these studies in mind, an attempt has been made to evaluate published cellular and molecular toxicity data related to Cd stress, and specifically published on S. cerevisiae.

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Authors and Affiliations

  1. Department of Botany and Centre for Environmental Studies, Ege University, Izmir, Turkey

    Munir Ozturk

  2. Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu, Fukuoka, 808-0135, Japan

    Mert Metin & Tomonori Kawano

  3. Department of Biology, Faculty of Science and Arts, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey

    Volkan Altay

  4. School of Life Sciences, University of Technology Sydney, Sydney, 123, Australia

    Luigi De Filippis

  5. Faculty of Science and Arts, Department of Biotechnology, Nigde Omer Halisdemir University, Nigde, Turkey

    Bengu Turkyilmaz Ünal

  6. Department of Biochemistry, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan

    Anum Khursheed

  7. Atta-ur-Rahman School of Applied Biosciences, National University of Sciences & Technology, Islamabad, Pakistan

    Alvina Gul

  8. Department of Agronomy, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh

    Mirza Hasanuzzaman

  9. Department of Agricultural Botany, Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh

    Kamuran Nahar

  10. Agronomy Department of Superior School Engineering, University of Almería, Ctra. Sacramento s/n, La Cañadade San Urbano, 04120, Almería, Spain

    Pedro García Caparrós

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  1. Munir Ozturk
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  2. Mert Metin
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  11. Pedro García Caparrós
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Contributions

The conception and design of the study: M.O., M.M., and V.A. Acquisition of data, analysis, and interpretation of data: M.O., M.M., V.A., B.T.U., A.K., A.G., M.H., K.N., T.K., and P.G.C. Drafting the article: M.O., M.M., V.A., A.K., A.G., M.H., K.N., and T.K. Revising the article critically for important intellectual content: M.O., V.A., A.K., A.G., M.H., K.N., and L.D. Final approval of the version to be submitted: M.O., V.A., and L.D.

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Correspondence to Munir Ozturk.

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Ozturk, M., Metin, M., Altay, V. et al. Molecular Biology of Cadmium Toxicity in Saccharomyces cerevisiae. Biol Trace Elem Res 199, 4832–4846 (2021). https://doi.org/10.1007/s12011-021-02584-7

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