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Prolidase-Associated Trace Elements (Mn, Zn, Co, and Ni) in the Patients with Parkinson’s Disease

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Abstract

Micronutrients and trace elements have been identified to play an important role in the development of Parkinson’s disease (PD). In our previous study, we observed that prolidase activity is associated with oxidative stress and progression of PD. In present study, we aimed to study the association of prolidase-associated trace elements, such as Co, Mn, Ni, and Zn in the plasma of patients with PD by inductively coupled plasma spectrometry. Plasma levels of Co, Mn, and Ni were significantly increased, whereas plasma levels of Zn was significantly decreased (all P < 0.05) in the patients with PD than healthy controls. Plasma prolidase activity was not correlated to its associated trace elements in PD. A positive, linear, and significant correlation was observed between age and Co, and Mn, and Ni while negative and non-significant between age and status of Zn in the patients. Co, Mn, and Ni were continually elevated with increase in age as well as duration of disease in the patients with PD, whereas status of Zn was continually decreased. Thus, the study concluded that trace elements Co, Ni, and Mn status were increased and Zn status was decreased in the plasma of patients with PD. It is also concluded that elevated Co, Mn, and Ni has been associated with progression of Parkinson’s disease.

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Acknowledgments

Facilities of ICP-OES spectrometry provided by Department of Chemical Engineering, IIT (BHU), are gratefully acknowledged. The authors are thankful to all the study subjects and the financial support provided by BHU. IMS-UGC-JRF/SRF fellowship received by AK Verma is highly acknowledged.

Conflict of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India

    Akhilesh Kumar Verma, Anand Kumar Keshari, Renu Kumari, Tarun Kumar & Ragini Srivastava

  2. Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India

    Janak Raj & Vivek Sharma

  3. Division of Biostatistics, Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India

    Tej Bali Singh

  4. Department of Oral Pathology, Jaipur Dental College, Jaipur, Rajasthan, 302020, India

    Shalabh Srivastava

Authors
  1. Akhilesh Kumar Verma
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  2. Anand Kumar Keshari
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  3. Janak Raj
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  4. Renu Kumari
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  5. Tarun Kumar
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  7. Tej Bali Singh
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  8. Shalabh Srivastava
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  9. Ragini Srivastava
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Correspondence to Ragini Srivastava.

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Verma, A.K., Keshari, A.K., Raj, J. et al. Prolidase-Associated Trace Elements (Mn, Zn, Co, and Ni) in the Patients with Parkinson’s Disease. Biol Trace Elem Res 171, 48–53 (2016). https://doi.org/10.1007/s12011-015-0503-4

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