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Sleep Symptoms in Migraine

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Abstract

Purpose of Review

To review replicated and highlight novel studies of sleep in children and adults with episodic and chronic migraine.

Recent Findings

Attack-related sleep symptoms are most common in the prodrome and may represent early activation of the hypothalamus rather than migraine triggers. Interictally, patients with migraine report poor sleep quality and high rates of insomnia symptoms. Cognitive behavioral therapy for insomnia in adults and adolescents with chronic migraine and comorbid insomnia results in significant improvement on their headache burden. Thus far, objective studies report that migraine per se is a not associated with sleep apnea. At the present time, there is minimal evidence that migraine is under circadian influence.

Summary

The current body of evidence suggests that the insomnia symptoms and poor sleep quality commonly reported by patients with migraine are not attack-related but occur interictally and are a marker of worsening disease. The development of clinical guidelines to approach sleep symptoms and expansion of CBT-I trials in those with episodic migraine would be clinically valuable.

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Data Availability

No datasets were generated or analysed during the current study.

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Authors and Affiliations

  1. Department of Neurology, Tufts Medicine, Tufts University School of Medicine, Boston, MA, USA

    Marc Daou

  2. Division of Headache Medicine, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Angeliki Vgontzas

  3. Graham Headache Center, Department of Neurology, Brigham and Women’s Faulkner Hospital, 1153 Centre Street Suite 4H, 02130, Boston, MA, USA

    Angeliki Vgontzas

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  1. Marc Daou
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MD and AV wrote the main manuscript text and MD prepared Fig. 1. All authors reviewed and approved the manuscript.

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Daou, M., Vgontzas, A. Sleep Symptoms in Migraine. Curr Neurol Neurosci Rep (2024). https://doi.org/10.1007/s11910-024-01346-x

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