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Response surface methodology for the evaluation of guanidine hydrochloride partitioning in polymer-salt aqueous two-phase system

  • Separation Technology, Thermodynamics
  • Published:
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Abstract

The current study employed response surface methodology (RSM) with a face-centered central composite design (CCD) to indicate the essential variables on the partition coefficient of guanidine hydrochloride (GuHCl) in the poly (ethylene glycol) (PEG)-phosphate aqueous two-phase system (ATPS). To evaluate the partition coefficients of GuHCl in the mentioned ATPS, the pH (7.0, 8.5 and 10.0), GuHCl concentration (1.0, 3.5 and 6.0% w/w), PEG molecular weight (2,000, 4,000 and 6,000 gmol−1) and PEG/potassium phosphate concentrations ratio were selected as independent variables. A quadratic model is suggested to find the impact of these variables. The suggested model has a strong harmony with the experimental data. The results of the model display that the GuHCl concentration and weight percent of the salt in feed have a large and small influence on the GuHCl partitioning.

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Authors and Affiliations

  1. Chemical Engineering Department, Faculty of Engineering, Shomal University, Amol, P. O. Box 731, Iran

    Mohsen Pirdashti, Abbas Ali Rostami & Behnia Shahrokhi

  2. Faculty of Chemical Engineering, Babol University of Technology, Babol, P. O. Box 484, Iran

    Kamyar Movagharnejad

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  1. Mohsen Pirdashti
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  2. Kamyar Movagharnejad
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  3. Abbas Ali Rostami
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Pirdashti, M., Movagharnejad, K., Rostami, A.A. et al. Response surface methodology for the evaluation of guanidine hydrochloride partitioning in polymer-salt aqueous two-phase system. Korean J. Chem. Eng. 34, 2033–2042 (2017). https://doi.org/10.1007/s11814-017-0108-z

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