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Effect of Gastric Bypass on Bone Mineral Density, Parathyroid Hormone and Vitamin D: 5 Years Follow-up

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Abstract

Background

The aim of the present study was to see if there are longitudinal changes in bone mineral density (BMD), vitamin D or parathyroid hormone (PTH) in females 5 years after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).

Methods

Thirty-two women with mean age 41.6 ± 9.3 years and mean body mass index (BMI) 44.5 ± 4.6 kg/m2 were included. Preoperatively, 2 and 5 years postoperatively, BMD, weight, height, S-calcium, S-albumin, S-creatinine, S-25(OH)-vitamin D and fP-PTH were measured.

Results

The mean decrease in BMI between baseline and 5 years after surgery was 29.4 %. BMD of the spine and femur measured as z- and t-scores, showed a linear, statistically significant declining trend over the years. The fall in BMD of the spine and femoral neck between baseline and 5 years after surgery was 19 and 25 %, respectively. The mean fP-PTH showed a significant increase over the study period (20.2 μg/L increase, 95 % CI:−31.99 to −8.41). S-calcium, both free and corrected for albumin, showed a decrease between baseline and 5 years after surgery.

Eight patients developed osteopenia and one osteoporosis after a 5-year follow-up.

Conclusion

LRYGB is an efficient method for sustained long-term body weight loss. There is, however, a concomitant decrease in BMD and S-calcium, and an increase in fP-PTH.

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Authors and Affiliations

  1. Lindesberg Hospital, Orebro, Sweden

    Mustafa Raoof, Ingmar Näslund, Eva Rask & Eva Szabo

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  1. Mustafa Raoof
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  2. Ingmar Näslund
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  3. Eva Rask
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  4. Eva Szabo
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Corresponding author

Correspondence to Mustafa Raoof.

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Conflict of Interest Statement

The authors declare that they have no competing interest.

Ethical Approval

The study was approved by the Ethics Committee of the Uppsala-Örebro Region in Sweden.

Informed Consent

All study participants signed a written informed consent form.

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Raoof, M., Näslund, I., Rask, E. et al. Effect of Gastric Bypass on Bone Mineral Density, Parathyroid Hormone and Vitamin D: 5 Years Follow-up. OBES SURG 26, 1141–1145 (2016). https://doi.org/10.1007/s11695-016-2114-3

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  • DOI: https://doi.org/10.1007/s11695-016-2114-3

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