Abstract
Summary
In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient.
Purpose
The aim of this study is to determine the association between 25-hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis.
Methodology
This study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of Hospital General Universitario de Ciudad Real between September 2016 and September 2018 is under consideration. The association between 25-hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level.
Results
Initial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA). Twenty-eight percent of patients showed increased levels of acute-phase reactants, and 82% exhibited 25-hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95%: 2.92–21.23, p = < 0.0001).
Conclusion
In this study, an association was found between those patients with spondyloarthritis who had a 25-hydroxyvitamin D deficiency and disease activity. Despite these results, a 1-year follow-up of these patients using two or more measurements of activity and 25-hydroxyvitamin D levels would be needed to corroborate these data.
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs11657-020-00805-5/MediaObjects/11657_2020_805_Fig1_HTML.png)
Similar content being viewed by others
References
Collantes-Estevez E (2013) New paradigms in the diagnosis and classification of the spondylarthritis. Reumatol Clin 9:199–200
Banegas ME, López C, Rozas ML, Fernández RM (2014) New ASAS criteria for the diagnosis of spondyloarthritis: diagnosing sacroiliitis by magnetic resonance imaging. Radiologia. 56:7–15
Rios V, Poddubnyy D (2015) Old and new treatment targets in axial spondyloarthritis. RMD Open 1(Suppl 1):e000054
Erten S, Kucuksahin O, Sahin A, Altunoglu A, Akyol M, Koca C (2013) Decreased plasma vitamin D levels in patients with undifferentiated spondyloarthritis and ankylosing spondylitis. Intern Med 52:339–344
Pokhai GG, Bandagi S, Abrudescu A (2014) Vitamin D levels in ankylosing spondylitis: does deficiency correspond to disease activity? Rev Bras Reumatol 54:330–334
Lange U, Teichmann J, Strunk J, Müller-Ladner U, Schmidt KL (2005) Association of 1.25 vitamin D3 deficiency, disease activity and low bone mass in ankylosing spondylitis. Osteoporos Int 16:1999–2004
Guta Z, Kopczynska A, Hanska K, Stomski M, Nowakowski J, Kwasny-Krochin B, Gasowski J, Korkosz M (2018) Vitamin D Serum concentration is not related to the activity of spondyloarthritis – preliminary study. Reumatología 56(6):388–391
Kolahi S, Khabbazi A, Kazemia N, Mahdavi AM (2019) Does vitamin D deficiency contribute to higher disease activity in patients with spondyloarthritis? Immunol Lett 212:1–5
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Castro Corredor, D., Ramírez Huaranga, M.A., Mínguez Sánchez, M.D. et al. Vitamin D, an inflammatory activity marker for spondyloarthritis?. Arch Osteoporos 15, 126 (2020). https://doi.org/10.1007/s11657-020-00805-5
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11657-020-00805-5