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The Role of No. 10 Lymphadenectomy for Advanced Proximal Gastric Cancer Patients Without Metastasis to No. 4sa and No. 4sb Lymph Nodes

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

There is no consensus in the impact of No. 10 lymph node dissection (LND) for advanced proximal gastric cancer (APGC) and the status of negative No. 4sa and No. 4sb lymph nodes (No. 4s LNs) is reportedly associated with no metastasis to No. 10 LN. We aimed to evaluate the role of No. 10 LND in APGC patients with negative No. 4s LNs and the diagnostic accuracy of intraoperative pathologic examination.

Methods

We analyzed data on 727 patients with APGC who had undergone D2 lymphadenectomy with No. 10 LND (n = 380) or without No. 10 LND (n = 347) between January 2005 and December 2010. Additionally, from January to July 2014, we prospectively enrolled 48 patients with APGC and examined their No. 4s LNs intraoperatively.

Results

The negative predictive efficacy of No. 4s LN status for no metastasis to No. 10 LN was 98.09 %. Operation time, blood loss, time to first solid diet, hospital stay, and postoperative complication rate differed significantly between patients with negative No. 4s LNs who underwent No. 10 LND (n = 260) and those who did not undergo No. 10 LND (n = 243). Differences between the two groups in 5-year overall and disease-free survival were not statistically significant. The sensitivity, specificity, and accuracy of intraoperative pathological examination of LNs were 93.42, 96.56, and 95.86 %, respectively.

Conclusions

The No. 10 lymphadenectomy may not be recommended in patients with APGC who are found by intraoperative pathological examination to have negative No. 4s LNs.

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Abbreviations

APGC:

Advanced proximal gastric cancer

No. 4s:

No. 4sa and No. 4sb

H&E:

Hematoxylin and eosin

IHC:

Immunohistochemistry

ITC:

Isolated tumor cells

LN:

Lymph node

LND:

Lymph node dissection

PBS:

Phosphate-buffered saline

PGC:

Proximal gastric cancer

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Acknowledgments

The authors thank Mrs. Yaqi Ma and Fengwei Zhu for their work in the intraoperative pathological examination of lymph nodes.

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    Authors and Affiliations

    1. Department of General Surgery, Chinese People’s Liberation Army General Hospital, 28 Fuxing Road, Bei**g, 100853, China

      Shibo Bian, Hongqing **, **aosong Wu, Jianxin Cui, Liangang Ma, Rong Chen, Bo Wei & Lin Chen

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    1. Shibo Bian
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    Correspondence to Lin Chen.

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    This study was performed in accordance with the Helsinki Declaration and was approved by the Institutional Review Board of the Chinese People’s Liberation Army General Hospital (S2013-116-01). Written informed consent was provided by all patients.

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    Shibo Bian and Hongqing ** contributed equally to this work.

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    Bian, S., **, H., Wu, X. et al. The Role of No. 10 Lymphadenectomy for Advanced Proximal Gastric Cancer Patients Without Metastasis to No. 4sa and No. 4sb Lymph Nodes. J Gastrointest Surg 20, 1295–1304 (2016). https://doi.org/10.1007/s11605-016-3113-3

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    • DOI: https://doi.org/10.1007/s11605-016-3113-3

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