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The Clinicopathological Features and Long-Term Survival Outcomes of Mucinous Gastric Carcinoma: a Consecutive Series of 244 Cases from a Single Institute

  • Original Article
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Journal of Gastrointestinal Surgery

Abstract

Background and Objectives

Mucinous gastric carcinoma (MGC) is a rare kind of malignancy with unclear prognosis. This study aims to assess the clinicopathological features and prognosis of MGC.

Methods

We retrospectively analyzed a consecutive series of 244 MGC patients who underwent radical gastrectomy with D2 lymphadenectomy, and compared the data with 260 gastric signet ring cell carcinoma (SRC) patients.

Results

The univariate survival analysis showed that the surgical types, diameter of the primary tumor, the Borrmann type, pathological depth of tumor invasion (pT), pathological number of metastatic lymph node (pN), pathological tumor lymph metastasis (pTNM), and vascular invasion were all significant predictors of survival (all P < 0.05). The multivariate survival analysis revealed that the diameter of the tumor, the Borrmann type, pT, pTNM stage, and vascular invasion as an independent predictive factor of survival (all P < 0.05). Compared with the SRC group, the MGC group had more male patients, more elder patients, larger tumor diameter, more T3 and T4 invasion to the gastric wall, more patients with metastatic lymph nodes, more pTNM stage III, and less Borrmann type 1. The overall survival rate of patients with MGC was significantly lower than that of patients with SRC (P < 0.001).

Conclusions

MGC was an aggressive malignancy which had unique clinicopathological features.

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Authors and Affiliations

  1. Department of Abdominal Surgery, Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 17, South of Pan Jiayuan Street, Chaoyang District, Bei**g, China

    **aolong Tang, Jianwei Zhang, Xu Che, Zhongmin Lan, Yingtai Chen & Chengfeng Wang

Authors
  1. **aolong Tang
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  2. Jianwei Zhang
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  3. Xu Che
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  4. Zhongmin Lan
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  5. Yingtai Chen
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  6. Chengfeng Wang
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Corresponding author

Correspondence to Chengfeng Wang.

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The authors declare that they have no competing interests.

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Tang, X., Zhang, J., Che, X. et al. The Clinicopathological Features and Long-Term Survival Outcomes of Mucinous Gastric Carcinoma: a Consecutive Series of 244 Cases from a Single Institute. J Gastrointest Surg 20, 693–699 (2016). https://doi.org/10.1007/s11605-015-3064-0

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  • DOI: https://doi.org/10.1007/s11605-015-3064-0

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