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Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis

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Abstract

Purpose

This study aims to investigate hippocampal subfield volumes in patients with hippocampal sclerosis (HS) without visually detectable MRI abnormalities and to determine the diagnostic accuracy using hippocampal subfield volumes.

Materials and methods

We examined 46 patients with unilateral HS who had a histopathological diagnosis, and 54 controls. The patients were divided into two groups; visually detectable HS (n = 26) and undetectable HS (n = 20) on MRI. The volumes of hippocampal subfield using FreeSurfer were compared among the three groups. Diagnostic accuracy was calculated as the AUC of ROC using cutoff values for each individual subfield.

Results

Compared with the controls, visually detectable HS showed significantly reduced volumes of all the hippocampal subfields and entire hippocampus, whereas visually undetectable HS showed significant atrophy only in the CA3 and hippocampus-amygdala-transition-area. To diagnose visually undetectable HS, the CA3 volumes had AUC of 0.719, which was higher than AUC of 0.614 based on the entire hippocampal volumes.

Conclusion

Visually undetectable HS demonstrated volume reductions in the CA3. Further, the CA3 volumes was more useful to diagnose visually undetectable HS compared with the entire hippocampal volumes.

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Abbreviations

CA:

Cornu ammonis

GC-DG:

Granule cell layer of dentate gyrus

HS:

Hippocampal sclerosis

HSV:

Hippocampal subfield volumetry

ILEA:

International league against epilepsy

MTLE:

Mesial temporal lobe epilepsy

SD:

Standard deviation

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Authors and Affiliations

  1. Department of Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

    Hiromi Masaki, Keita Watanabe, Shingo Kakeda, Satoru Ide, Kohichiro Sugimoto, Issei Ueda, Toshihiko Hamamura, Sachi Hisanaga & Yukunori Korogi

  2. Department of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan

    Tomoko Toyota, Naoki Akamatsu & Hiroaki Adachi

  3. Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Shohei Shimajiri

  4. Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan

    Junkoh Yamamoto & Shigeru Nishizawa

  5. Department of Neurology, School of Medicine, International University of Health and Welfare, Otawara, Japan

    Naoki Akamatsu

  6. Department of Diagnostic Radiology, Hirosaki University Graduate School of Medicine Radiology, Aomori, Japan

    Shingo Kakeda

  7. Open Innovation Institute, Kyoto University, Kyoto, Japan

    Keita Watanabe

Authors
  1. Hiromi Masaki
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  2. Keita Watanabe
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  8. Sachi Hisanaga
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  9. Tomoko Toyota
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  14. Hiroaki Adachi
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  15. Yukunori Korogi
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Corresponding author

Correspondence to Keita Watanabe.

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Masaki, H., Watanabe, K., Kakeda, S. et al. Hippocampal sclerosis without visually detectable hippocampal MRI abnormalities: automated subfield volumetric analysis. Jpn J Radiol 38, 1020–1027 (2020). https://doi.org/10.1007/s11604-020-01019-y

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  • DOI: https://doi.org/10.1007/s11604-020-01019-y

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