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Protein self-assembly: technology and strategy

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Abstract

Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological studies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly strategy to unravel the formation and function of protein nanostructures. In this review, we summarize the progress made in the engineering of supramolecular protein architectures according to the strategies used to control the orientation and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed.

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Authors and Affiliations

  1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China

    Linlu Zhao, Shanpeng Qiao & Junqiu Liu

Authors
  1. Linlu Zhao
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  2. Shanpeng Qiao
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  3. Junqiu Liu
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Corresponding author

Correspondence to Junqiu Liu.

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These authors contributed equally to this work.

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Zhao, L., Qiao, S. & Liu, J. Protein self-assembly: technology and strategy. Sci. China Chem. 59, 1531–1540 (2016). https://doi.org/10.1007/s11426-016-0231-3

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  • DOI: https://doi.org/10.1007/s11426-016-0231-3

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