Abstract
Nickel (Ni) is a heavy metal element and a pollutant that threatens the organism’s health. Melatonin (Mel) is an antioxidant substance that can be secreted by the organism and has a protective effect against heavy metals. Selenoprotein M (SelM) is a selenoprotein widely distributed of the body, and its role is to protect these tissues from oxidative damage. To study the mechanism of Ni, Mel, and SelM in mouse spleen, 80 SelM+/+ wild-type and 80 SelM−/− homozygous mice were divided into 8 groups with 20 mice in each group. The Ni group was intragastric at a concentration of 10 mg/kg, while the Mel group was intragastric at 2 mg/kg. Mice were injected with 0.1 mL/10 g body weight for 21 days. Histopathological and ultrastructural observations showed the changes in Ni, such as the destruction of white and red pulp and the appearance of pyroptosomes. SelM knockout showed more severe injury, while Mel could effectively interfere with Ni-induced spleen toxicity. The results of antioxidant capacity determination showed that Ni could cause oxidative stress in the spleen, and Mel could also effectively reduce oxidative stress. Finally, Ni exposure increased the expression levels of the pyroptotic genes, including apoptosis-associated speck protein (ASC), absent in melanoma-2 (AIM2), NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), Caspase-1, interleukin- (IL-) 18, and IL-1β (p < 0.05). Loss of SelM significantly increased these (p < 0.05), while Mel decreased the alleviated impact of Ni. In conclusion, the loss of SelM aggravated Ni-induced pyroptosis of the spleen via activating oxidative stress, which was alleviated by Mel, but the effect of Mel was not obvious in the absence of SelM, which reflected the important role of SelM in Ni-induced pyroptosis.
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Abbreviations
- Ni:
-
Nickel
- Mel:
-
Melatonin
- SelM:
-
Selenoprotein M
- H&E:
-
Hematoxylin-eosin
- SOD:
-
Superoxide dismutase
- T-AOC:
-
Total antioxidant capacity
- MDA:
-
Malondialdehyde
- GSSG:
-
Oxidized glutathione disulfide
- GSH:
-
Reduced glutathione
- qRT-PCR:
-
Quantitative real-time polymerase chain reaction
- PMSF:
-
Phenylmethylsulfonyl fluoride
- BCA:
-
Bicinchoninic acid
- NC:
-
Nitrocellulose
- BSA:
-
Bovine serum albumin
- LY:
-
Lymphocytes
- SP:
-
Spleen cord
- SS:
-
Spleen sinus
- WP:
-
White pulp
- RP:
-
Red pulp
- RSC:
-
Red blood cells
- ASC:
-
Apoptosis-associated speck protein
- AIM2:
-
Absent in melanoma-2
- NOX2:
-
Nicotinamide adenine dinucleotide phosphate oxidase 2
- NLRP3:
-
NOD-like receptor thermal protein domain-associated protein 3
- TXNIP:
-
Thioredoxin-interacting protein
- TRXI:
-
Time-resolved x-ray imager
- IL-18:
-
Interleukin- (IL-) 18
- PRRs:
-
Pattern recognition receptors
- GSDMD:
-
gasdermin D
References
Al Mamun A, Mimi AA, Aziz MA, Zaeem M, Ahmed T, Munir F, **ao J (2021) Role of pyroptosis in cancer and its therapeutic regulation. Eur J Pharmacol 5(910):174444. https://doi.org/10.1016/j.ejphar.2021.174444
Al Mamun A, Wu Y, Jia C, Munir F, Sathy KJ, Sarker T, Monalisa I, Zhou K, **ao J (2020) Role of pyroptosis in liver diseases. Int Immunopharmacol 84:106489. https://doi.org/10.1016/j.intimp.2020.106489
Boulila S, El Feki A, Oudadesse H, Kallel C, El Feki H (2014) Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate. Ann Pharm Fr 72(5):348–362. https://doi.org/10.1016/j.pharma.2014.03.004
Buxton S, Taylor MD, Weinberg JT, Randazzo JM, Peachee VL, Oller A (2021) A T-dependent antibody response evaluation in CD-1 mice after an acute whole-body inhalation exposure to nickel (II) chloride hexahydrate. J Immunotoxicol 18(1):144–153. https://doi.org/10.1080/1547691X.2021.1984618
Cai J, Guan H, Jiao X, Yang J, Chen X, Zhang H, Zheng Y, Zhu Y, Liu Q (2021) Zhang Z (2021) NLRP3 inflammasome mediated pyroptosis is involved in cadmium exposure-induced neuroinflammation through the IL-1β/IkB-α-NF-κB-NLRP3 feedback loop in swine. Toxicology 15(453):152720. https://doi.org/10.1016/j.tox.2021.152720
Cai J, Huang J, Yang J, Chen X, Zhang H, Zhu Y, Liu Q, Zhang Z (2022) The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1-MFN2 pathway and Parkin mitophagy. Cell Mol Life Sci 9 79(7):354. https://doi.org/10.1007/s00018-022-04385-0
Cai J, Yang J, Chen X, Zhang H, Zhu Y, Liu Q, Zhang Z (2022b) Melatonin ameliorates trimethyltin chloride-induced cardiotoxicity: the role of nuclear xenobiotic metabolism and Keap1-Nrf2/ARE axis-mediated pyroptosis. BioFactors 48(2):481–497. https://doi.org/10.1002/biof.1787
Chen P, Wang RR, Ma XJ, Liu Q, Ni JZ (2013) Different forms of selenoprotein M differentially affect Aβ aggregation and ROS generation. Int J Mol Sci 14(3):4385–4399. https://doi.org/10.3390/ijms14034385
Chen X, Bi M, Yang J, Cai J, Zhang H, Zhu Y, Zheng Y, Liu Q, Shi G, Zhang Z (2021) Cadmium exposure triggers oxidative stress, necroptosis, Th1/Th2 imbalance and promotes inflammation through the TNF-α/NF-κB pathway in swine small intestine. J Hazard Mater 421:126704. https://doi.org/10.1016/j.jhazmat.2021.126704
Chi Q, Zhang Q, Lu Y, Zhang Y, Xu S, Li S (2021) Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis. Redox Biol 44:102003. https://doi.org/10.1016/j.redox.2021.102003
Chu JH, Yan YX, Gao PC, Chen XW, Fan RF (2020) Response of selenoproteins gene expression profile to mercuric chloride exposure in chicken kidney. Res Vet Sci 133:4–11. https://doi.org/10.1016/j.rvsc.2020.08.020
Du T, Gao J, Li P, Wang Y, Qi Q, Liu X, Li J, Wang C, Du L (2021) Pyroptosis, metabolism, and tumor immune microenvironment. Clin Transl Med 11(8):e492. https://doi.org/10.1002/ctm2.492
Fomenko DE, Gladyshev VN (2003) Genomics perspective on disulfide bond formation. Antioxid Redox Signal 5(4):397–402. https://doi.org/10.1089/152308603768295131
Guo H, Deng H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2021) Nickel carcinogenesis mechanism: cell cycle dysregulation. Environ Sci Pollut Res Int 28(5):4893–4901. https://doi.org/10.1007/s11356-020-11764-2
Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L, He R, Tang H (2020) Immunotoxicity of nickel: pathological and toxicological effects. Ecotoxicol Environ Saf 203:111006. https://doi.org/10.1016/j.ecoenv.2020.111006
Harkin A, Hynes MJ, Masterson E, Kelly JP, O’Donnell JM, Connor TJ (2003) A toxicokinetic study of nickel-induced immunosuppression in rats. Immunopharmacol Immunotoxicol 25(4):655–670. https://doi.org/10.1081/iph-120026448
Hofstee P, Perkins AV, Cuffe JSM (2022) Selenium deficiency during pregnancy in mice impairs exercise performance and metabolic function in adult offspring. Nutrients 14(5):1125. https://doi.org/10.3390/nu14051125
Hu Y, Wang B, Li S, Yang S (2022) Pyroptosis, and its role in central nervous system disease. J Mol Biol 434(4):167379. https://doi.org/10.1016/j.jmb.2021.167379
Huang J, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wang X, Wu B (2014) Downregulation of TLR4 and 7 mRNA expression levels in broiler’s spleen caused by diets supplemented with nickel chloride. Biol Trace Elem Res 158(3):353–358. https://doi.org/10.1007/s12011-014-9938-2
Huang JQ, Ren FZ, Jiang YY, Lei X (2016) Characterization of selenoprotein M and its response to selenium deficiency in chicken brain. Biol Trace Elem Res 170(2):449–458. https://doi.org/10.1007/s12011-015-0486-1
**g H, Wang F, Gao XJ (2022) Lithium intoxication induced pyroptosis via ROS/NF-κB/NLRP3 inflammasome regulatory networks in kidney of mice. Environ Toxicol 37(4):825–835. https://doi.org/10.1002/tox.23446
Khoso PA, Yang Z, Liu C, Li S (2015a) Selenium deficiency downregulates selenoproteins and suppresses immune function in chicken thymus. Biol Trace Elem Res 167(1):48–55. https://doi.org/10.1007/s12011-015-0282-y
Khoso PA, Yang Z, Liu C, Li S (2015b) Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency. Cell Stress Chaperones 20(6):967–978. https://doi.org/10.1007/s12192-015-0625-9
Khoso PA, Zhang Y, Yin H, Teng X, Li S (2019) Selenium deficiency affects immune function by influencing selenoprotein and cytokine expression in chicken spleen. Biol Trace Elem Res 187(2):506–516. https://doi.org/10.1007/s12011-018-1396-9
Kubrak OI, Husak VV, Rovenko BM, Poigner H, Mazepa MA, Kriews M, Abele D, Lushchak VI (2012) Tissue specificity in nickel uptake and induction of oxidative stress in kidney and spleen of goldfish Carassius auratus, exposed to waterborne nickel. Aquat Toxicol 118–119:88–96. https://doi.org/10.1016/j.aquatox.2012.03.016
Kvetnoy I, Ivanov D, Mironova E, Evsyukova I, Nasyrov R, Kvetnaia T, Polyakova V (2022) Melatonin as the cornerstone of neuroimmunoendocrinology. Int J Mol Sci 23(3):1835. https://doi.org/10.3390/ijms23031835
Li J, Zhang W, Zhou P, Tong X, Guo D, Lin H (2022a) Selenium deficiency induced apoptosis via mitochondrial pathway caused by oxidative stress in porcine gastric tissues. Res Vet Sci 144:142–148. https://doi.org/10.1016/j.rvsc.2021.10.017
Li X, Bai R, Bai Y, Shi X, Yang Y, Xu S (2022b) ROS-mediated PPAR/RXR inhibition contributes to acetochlor-induced apoptosis and autophagy in Ctenopharyngodon idella hepatic cells. Fish Shellfish Immunol 128:684–694. https://doi.org/10.1016/j.fsi.2022.08.053
Li X, Bai Y, Zhu W, Shi X, Xu S (2022c) The endoplasmic reticulum-mitochondrial crosstalk is involved in the mitigation mechanism of eucalyptol on imidacloprid toxicity in Ctenopharyngodon idellus kidney cells. Fish Shellfish Immunol 127:99–108. https://doi.org/10.1016/j.fsi.2022.06.014
Li X, **ng M, Chen M, Zhao J, Fan R, Zhao X, Cao C, Yang J, Zhang Z, Xu S (2017) Effects of selenium-lead interaction on the gene expression of inflammatory factors and selenoproteins in chicken neutrophils. Ecotoxicol Environ Saf 139:447–453. https://doi.org/10.1016/j.ecoenv.2017.02.017
Li X, Yao Y, Wang J, Shen Z, Jiang Z, Xu S (2022d) Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells. Aquat Toxicol 249:106204. https://doi.org/10.1016/j.aquatox.2022.106204
Li X, Zhang H, Qiao S, Ma W, Cai J, Zhang X, Zhang Z (2022e) Melatonin administration alleviates 2,2,4,4-tetra-brominated diphenyl ether (PBDE-47)-induced necroptosis and secretion of inflammatory factors via miR-140-5p/TLR4/NF-κB axis in fish kidney cells. Fish Shellfish Immunol 128:228–237. https://doi.org/10.1016/j.fsi.2022.08.004
Liang F, Zhang F, Zhang L, Wei W (2020) The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases. Inflamm Res 69(2):159–166. https://doi.org/10.1007/s00011-020-01315-3
Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X, Zhao Z, Liu G, Li H (2022) Selenium deficiency leads to changes in renal fibrosis marker proteins and Wnt/β-catenin signaling pathway components. Biol Trace Elem Res 200(3):1127–1139. https://doi.org/10.1007/s12011-021-02730-1
Liu J, Sun Q, Sun M, Lin L, Ren X, Li T, Xu Q, Sun Z, Duan J (2022a) Melatonin alleviates PM2.5-triggered macrophage M1 polarization and atherosclerosis via regulating NOX2-mediated oxidative stress homeostasis. Free Radic Biol Med 181:166–179. https://doi.org/10.1016/j.freeradbiomed.2022.02.005
Liu Q, Du P, Zhu Y, Zhang X, Cai J, Zhang Z (2022b) Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis. Cell Mol Life Sci 79(2):106. https://doi.org/10.1007/s00018-022-04155-y
Liu Q, Sun Y, Zhu Y, Qiao S, Cai J, Zhang Z (2022c) Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-β1 axis activation. Life Sci 301:120622. https://doi.org/10.1016/j.lfs.2022.120622
Luan P, Zhang H, Chen X, Zhu Y, Hu G, Cai J, Zhang Z (2022) Melatonin relieves 2,2,4,4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish kidney cells (CIK). Ecotoxicol Environ Saf 232:113276. https://doi.org/10.1016/j.ecoenv.2022.113276
Miao Z, Miao Z, Teng X, Xu S (2022) Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124–3p/CAPN1 axis. J Hazard Mater 424(PtA):127318. https://doi.org/10.1016/j.jhazmat.2021.127318
Pan T, Liu T, Tan S, Wan N, Zhang Y, Li S (2018) Lower selenoprotein T expression and immune response in the immune organs of broilers with exudative diathesis due to selenium deficiency. Biol Trace Elem Res 182(2):364–372. https://doi.org/10.1007/s12011-017-1110-3
Park H, Kim J (2022) Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer’s disease mouse model. J Pineal Res 72(3):e12787. https://doi.org/10.1111/jpi.12787
Qiao S, Sun Y, Jiang Y, Chen X, Cai J, Liu Q, Zhang Z (2022) Melatonin ameliorates nickel induced autophagy in mouse brain: diminution of oxidative stress. Toxicology 473:153207. https://doi.org/10.1016/j.tox.2022.153207
Qin L, Zhang Y, Wan C, Wang Z, Cong Y, Li S (2020) MiR-196-5p involvement in selenium deficiency-induced immune damage via targeting of NFκBIA in the chicken trachea. Metallomics 12(11):1679–1692. https://doi.org/10.1039/d0mt00164c
Qing Z, Dongliu L, Xuedie G, Khoso PA, **aodan H, Shu L (2022) MiR-144-3p targets STC1 to activate PI3K/AKT pathway to induce cell apoptosis and cell cycle arrest in selenium deficiency broilers. J Inorg Biochem 226:111665. https://doi.org/10.1016/j.**orgbio.2021.111665
Romero A, Ramos E, de Los Ríos C, Egea J, Del Pino J, Reiter RJ (2014) A review of metal-catalyzed molecular damage: protection by melatonin. J Pineal Res 56(4):343–70. https://doi.org/10.1111/jpi.12132
Shaban NZ, Abd El-Kader SE, Mogahed FAK, El-Kersh MAL, Habashy NH (2021) Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats. Sci Rep 11(1):252. https://doi.org/10.1038/s41598-020-80669-4
Shaban NZ, Abdelrahman SA, El-Kersh MAL, Mogahed FAK, Talaat IM, Habashy NH (2020) The synergistic hepatoprotective potential of Beta vulgaris juice and 2,3-dimercaptosuccinic acid in lead-intoxicated rats via improving the hepatic oxidative and inflammatory stress. BMC Complement Med Ther 20(1):268. https://doi.org/10.1186/s12906-020-03056-6
Shaban NZ, Aboelsaad AM, Awad D, Abdulmalek SA, Shaban SY (2022a) Therapeutic effect of dithiophenolato chitosan nanocomposites against carbon tetrachloride-induced hepatotoxicity in rats. Environ Sci Pollut Res Int 29(6):8487–8502. https://doi.org/10.1007/s11356-021-15834-x
Shaban NZ, Ahmed Zahran AM, El-Rashidy FH, Abdo Kodous AS (2017) Protective role of hesperidin against γ-radiation-induced oxidative stress and apoptosis in rat testis. J Biol Res (thessalon) 24:5. https://doi.org/10.1186/s40709-017-0059-x
Shaban NZ, El-Kersh MA, El-Rashidy FH, Habashy NH (2013) Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats. Food Chem 141(3):1587–1596. https://doi.org/10.1016/j.foodchem.2013.04.134
Shaban NZ, Zaki MM, Koutb F, Abdul-Aziz AA, Elshehawy AA, Mehany H (2022b) Protective and therapeutic role of mango pulp and eprosartan drug and their anti-synergistic effects against thioacetamide-induced hepatotoxicity in male rats. Environ Sci Pollut Res Int 29(34):51427–51441. https://doi.org/10.1007/s11356-022-19383-9
Song N, Li X, Cui Y, Zhang T, Xu S, Li S (2021) Hydrogen sulfide exposure induces pyroptosis in the trachea of broilers via the regulatory effect of circRNA-17828/miR-6631-5p/DUSP6 crosstalk on ROS production. J Hazard Mater 418:126172. https://doi.org/10.1016/j.jhazmat.2021.126172
Tsuchiya K (2021) Switching from apoptosis to pyroptosis: gasdermin-elicited inflammation and antitumor immunity. Int J Mol Sci 22(1):426. https://doi.org/10.3390/ijms22010426
Varlamova EG, Goltyaev MV, Fesenko EE (2019) Protein partners of selenoprotein SELM and the role of selenium compounds in regulation of its expression in human cancer cells. Dokl Biochem Biophys 488(1):300–303. https://doi.org/10.1134/S1607672919050065
Wang Q, Wu J, Zeng Y, Chen K, Wang C, Yang S, Sun N, Chen H, Duan K, Zeng G (2020) Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease. Clin Chim Acta 510:62–72. https://doi.org/10.1016/j.cca.2020.06.044
Wang S, Zhao X, Liu Q, Wang Y, Li S, Xu S (2022) Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation. Redox Biol 50:102255. https://doi.org/10.1016/j.redox.2022.102255
Wu B, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wang X, Huang J (2015) Toxicological effects of nickel chloride on the cytokine mRNA expression and protein levels in intestinal mucosal immunity of broilers. Environ Toxicol 30(11):1309–1321. https://doi.org/10.1002/tox.22001
Wu H, Guo J, Yao Y, Xu S (2022) Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production. Fish Shellfish Immunol 125:1–8. https://doi.org/10.1016/j.fsi.2022.04.048
Wu J, Sun J, Meng X (2021) Pyroptosis by caspase-11 inflammasome-gasdermin D pathway in autoimmune diseases. Pharmacol Res 165:105408. https://doi.org/10.1016/j.phrs.2020.105408
Xu SC, He MD, Zhong M, Zhang YW, Wang Y, Yang L, Yang J, Yu ZP, Zhou Z (2010) Melatonin protects against nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function. J Pineal Res 49(1):86–94. https://doi.org/10.1111/j.1600-079X.2010.00770.x
Xu S, **ao**g L, **nyue S, Wei C, Honggui L, Shiwen X (2021) Pig lung fibrosis is active in the subacute CdCl2 exposure model and exerts cumulative toxicity through the M1/M2 imbalance. Ecotoxicol Environ Saf 1(225):112757. https://doi.org/10.1016/j.ecoenv.2021.112757
Xu Y, Li A, Li X, Deng X, Gao XJ (2022) Zinc deficiency induces inflammation and apoptosis via oxidative stress in the kidneys of mice. Biol Trace Elem Res. https://doi.org/10.1007/s12011-022-03166-x
Xue Y, Wang H, Tian B, Wang S, Gao XJ (2022) Selenium deficiency promotes the expression of lncRNA-MORC3, activating NLRP3-caspase-1/IL-1β signaling to induce inflammatory damage and disrupt tight junctions in piglets. Biol Trace Elem Res. https://doi.org/10.1007/s12011-022-03341-0
Yang J, Shi G, Gong Y, Cai J, Zheng Y, Zhang Z (2021) LncRNA 0003250 accelerates heart autophagy and binds to miR-17-5p as a competitive endogenous RNA in chicken induced by selenium deficiency. J Cell Physiol 236(1):157–177. https://doi.org/10.1002/jcp.29831
Yim SY, Chae KR, Shim SB, Hong JT, Park JY, Lee CY, Son HJ, Sheen YY, Hwang DY (2009) ERK activation induced by selenium treatment significantly downregulates beta/gamma-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Int J Mol Med 24(1):91–96. https://doi.org/10.3892/ijmm-00000211
Yu D, Zhang Z, Yao H, Li S, Xu SW (2015) The role of selenoprotein W in inflammatory injury in chicken immune tissues and cultured splenic lymphocyte. Biometals 28(1):75–87. https://doi.org/10.1007/s10534-014-9804-x
Yu H, Zhang J, Ji Q, Yu K, Wang P, Song M, Cao Z, Zhang X, Li Y (2019) Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway. Ecotoxicol Environ Saf 173:131–141. https://doi.org/10.1016/j.ecoenv.2019.01.095
Yu SY, Li XL (2021) Pyroptosis and inflammasomes in obstetrical and gynecological diseases. Gynecol Endocrinol 37(5):385–391. https://doi.org/10.1080/09513590.2021.1871893
Zhang H, Huang J, Yang J, Cai J, Liu Q, Zhang X, Bao J, Zhang Z (2022) Zhang Z Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway. Environ Sci Pollut Res Int 29(27):41207–41218. https://doi.org/10.1007/s11356-022-18863-2
Zhang H, Huang J, Yang J, Cai J, Liu Q, Zhang X, Bao J, Zhang Z (2022b) Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway. Environ Sci Pollut Res Int 29(27):41207–41218. https://doi.org/10.1007/s11356-022-18863-2
Zhang Q, Xue Y, Fu Y, Bao B, Guo MY (2022c) Zinc deficiency aggravates oxidative stress leading to inflammation and fibrosis in lung of mice. Biol Trace Elem Res 200(9):4045–4057. https://doi.org/10.1007/s12011-021-03011-7
Zhang Y, Liu Q, Yin H, Li S (2020) Cadmium exposure induces pyroptosis of lymphocytes in carp pronephros and spleens by activating NLRP3. Ecotoxicol Environ Saf 202:110903. https://doi.org/10.1016/j.ecoenv.2020.110903
Zhang Y, Xu Y, Chen B, Zhao B, Gao XJ (2021a) Selenium deficiency promotes oxidative stress-induced mastitis via activating the NF-κB and MAPK pathways in dairy cow. Biol Trace Elem Res 200(6):2716–2726. https://doi.org/10.1007/s12011-021-02882-0
Zhang Y, Zhang J, Bao J, Tang C, Zhang Z (2021b) Selenium deficiency induced necroptosis, Th1/Th2 imbalance, and inflammatory responses in swine ileum. J Cell Physiol 236(1):222–234. https://doi.org/10.1002/jcp.29836
Zhao J, Jiang P, Guo S, Schrodi SJ, He D (2021) Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis. Front Immunol 12:809806. https://doi.org/10.3389/fimmu.2021.809806
Zheng Y, Guan H, Yang J, Cai J, Liu Q, Zhang Z (2021a) Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine. Anim Nutr 7(4):997–1008. https://doi.org/10.1016/j.aninu.2021.05.005
Zheng Y, Zhang B, Guan H, Jiao X, Yang J, Cai J, Liu Q, Zhang Z (2021b) Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine. BioFactors 47(5):788–800. https://doi.org/10.1002/biof.1762
Zhong XY, Ruan S, Wang F, Chen B, Luo J, Wang YX, Liang H (2022) Electroacupuncture ameliorates ischemic injury in cerebral ischemia-reperfusion rats by regulating endogenous melatonin and inhibiting the activation of astrocytes. Zhen Ci Yan Jiu 47(1):39–45. https://doi.org/10.13702/j.1000-0607.20210738. (Chinese)
Zhou X, Zhang Y, Hou M, Liu H, Yang H, Chen X, Liu T, He F, Zhu X (2022) Melatonin prevents cartilage degradation in early-stage osteoarthritis through activation of miR-146a/NRF2/HO-1 axis. J Bone Miner Res 37(5):1056–1072. https://doi.org/10.1002/jbmr.4527
Zhu Y, Jiao X, An Y, Li S, Teng X (2017) Selenium against lead-induced apoptosis in chicken nervous tissues via mitochondrial pathway. Oncotarget 8(64):108130–108145. https://doi.org/10.18632/oncotarget.22553
Zhu Y, Luan P, Liu X, Bao J, Liu Q, Cai J, Yang J, Zhang Z (2021) Crosstalk between autophagy and apoptosis regulates cerebral cortex and cerebellum neurodegeneration induced by cadmium in swine via the PI3K/AKT/AMPK pathway. Ecotoxicol Environ Saf 228.https://doi.org/10.1016/j.ecoenv.2021.113053
Zuo Y, Chen L, Gu H, He X, Ye Z, Wang Z, Shao Q (2021) Xue C (2021) GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy. Expert Rev Mol Med 27(23):e23. https://doi.org/10.1017/erm.2021.27
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This work was supported by the National Natural Science Foundation of China (31872531) and Excellent Youth Foundation of Heilongjiang Province of China (YQ2021C021).
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Wenxue Ma: conceptualization, methodology, software, investigation, and writing—original draft. Yue Liu: formal analysis. Lihua Xu: visualization. **aoxue Gai: validation. Yue Sun: formal analysis. Senqiu Qiao: software. Pinnan Liu: supervision. Qiaohan Liu: data curation. Ziwei Zhang: writing—review and editing.
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Ma, W., Liu, Y., Xu, L. et al. The role of selenoprotein M in nickel-induced pyroptosis in mice spleen tissue via oxidative stress. Environ Sci Pollut Res 30, 34270–34281 (2023). https://doi.org/10.1007/s11356-022-24597-y
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DOI: https://doi.org/10.1007/s11356-022-24597-y