SpringerLink
Log in

Association between environmental phenols and all-cause and cancer mortality

  • Research Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

To study the association between environmental phenols exposure, including benzophenone-3 (BP3) and triclosan, and all-cause mortality and cancer mortality in adults. A total of 8035 participants were included from the National Health and Nutrition Examination Survey (2003–2012). Urinary BP3 and triclosan were measured with liquid chromatography-tandem mass spectrometry. The associations between urinary BP3 and triclosan with cancer and all-cause mortality were explored by multivariable logistic regressions and restricted cubic splines. During an average of 7.25-year follow-up, 696 cases (8.7%) of all-cause mortality and 137 cases (1.71%) of cancer mortality occurred. The average levels of BP3 and triclosan were 12.2 and 10.3 ng/mL, respectively. Compared with the lowest quartile, the multivariable-adjusted hazard ratio of the highest quartile was 0.64 (95% confidence interval: 0.50 to 0.81; P < 0.001) for BP3 and 0.76 (0.61 to 0.94; P = 0.011) for triclosan. However, no significant associations between urinary BP3 and triclosan and cancer mortality were observed. BP3 and triclosan exposure decreased the risk of all-cause mortality while they were not associated with cancer mortality.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

All the data could be available upon request from the corresponding author.

References

  • Aker AM, Watkins DJ, Johns LE, Ferguson KK, Soldin OP, Anzalota Del Toro LV, Alshawabkeh AN, Cordero JF, Meeker JD (2016) Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women. Environ Res 151:30–37

    Article  CAS  Google Scholar 

  • Bao W, Liu B, Rong S, Dai SY, Trasande L, Lehmler HJ (2020) Association between bisphenol A exposure and risk of all-cause and cause-specific mortality in US adults. JAMA Netw Open 3:e2011620

    Article  Google Scholar 

  • DiNardo JC, Downs CA (2018) Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-3. J Cosmet Dermatol 17:15–19

    Article  Google Scholar 

  • Farasani A, Darbre PD (2021) Long-term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro. J Appl Toxicol 41:1115–1126

    Article  CAS  Google Scholar 

  • Huo W, Cai P, Chen M, Li H, Tang J, Xu C, Zhu D, Tang W, **a Y (2016) The relationship between prenatal exposure to BP-3 and Hirschsprung’s disease. Chemosphere 144:1091–1097

    Article  CAS  Google Scholar 

  • Jamal A, Rastkari N, Dehghaniathar R, Nodehi RN, Nasseri S, Kashani H, Shamsipour M, Yunesian M (2020) Prenatal urinary concentrations of environmental phenols and birth outcomes in the mother-infant pairs of Tehran Environment and Neurodevelopmental Disorders (TEND) cohort study. Environ Res 184:109331

    Article  CAS  Google Scholar 

  • Liang Y, Wang X, Dong S, Liu Z, Mu J, Lu C, Zhang J, Li M, Xue L, Wang W (2020) Size distributions of nitrated phenols in winter at a coastal site in north China and the impacts from primary sources and secondary formation. Chemosphere 250:126256

    Article  CAS  Google Scholar 

  • Poiger T, Buser HR, Balmer ME, Bergqvist PA, Muller MD (2004) Occurrence of UV filter compounds from sunscreens in surface waters: regional mass balance in two Swiss lakes. Chemosphere 55:951–963

    Article  CAS  Google Scholar 

  • Shane HL, Othumpangat S, Marshall NB, Blachere F, Lukomska E, Weatherly LM, Baur R, Noti JD, Anderson SE (2020) Topical exposure to triclosan inhibits Th1 immune responses and reduces T cells responding to influenza infection in mice. PLoS ONE 15:e0244436

    Article  CAS  Google Scholar 

  • Tang N, Fan P, Chen L, Yu X, Wang W, Wang W, Ouyang F (2022) The effect of early life exposure to triclosan on thyroid follicles and hormone levels in zebrafish. Front Endocrinol (lausanne) 13:850231

    Article  Google Scholar 

  • Tao J, Bai C, Chen Y, Zhou H, Liu Y, Shi Q, Pan W, Dong H, Li L, Xu H, Tanguay R, Huang C, Dong Q (2020) Environmental relevant concentrations of benzophenone-3 induced developmental neurotoxicity in zebrafish. Sci Total Environ 721:137686

    Article  CAS  Google Scholar 

  • Utsunomiya H, Hiraishi R, Kishimoto K, Hamada S, Abe S, Bekki Y, Kamemura N (2019) Cytotoxicity of benzophenone-3, an organic ultraviolet filter, caused by increased intracellular Zn(2+) levels in rat thymocytes. Chem Biol Interact 298:52–56

    Article  CAS  Google Scholar 

  • Weatherly LM, Gosse JA (2017) Triclosan exposure, transformation, and human health effects. J Toxicol Environ Health B Crit Rev 20:447–469

    Article  CAS  Google Scholar 

  • Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH (2020) Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259–31266

    Article  CAS  Google Scholar 

  • Ziarrusta H, Mijangos L, Picart-Armada S, Irazola M, Perera-Lluna A, Usobiaga A, Prieto A, Etxebarria N, Olivares M, Zuloaga O (2018) Non-targeted metabolomics reveals alterations in liver and plasma of gilt-head bream exposed to oxybenzone. Chemosphere 211:624–631

    Article  CAS  Google Scholar 

Download references

Funding

This study was supported by the National Natural Science Foundation of China Grants (No. 81570184).

Author information

Author notes

  1. **g He, Qingfeng Xue, and **n Hua contributed equally

Authors and Affiliations

  1. Department of Chemotherapy, Affiliated Hospital of Nantong University, 20 **si Road, Nantong, 226001, China

    **g He & Wenyu Shi

  2. Medical School of Nantong University, Nantong, 226001, China

    **g He, Qingfeng Xue, **n Hua, Quanqing Li & Wenyu Shi

  3. Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 **si Road, Nantong, 226001, China

    **g He & Wenyu Shi

  4. Department of Oncology, Affiliated Hospital of Nantong University, 20 **si Road, Nantong, 226001, China

    Qingfeng Xue, **n Hua, Quanqing Li & Wenyu Shi

  5. Department of Cardiology, Affiliated Hospital of Nantong University, 20 **si Road, Nantong, 226001, China

    Ziwei Chen

  6. Department of Psychology, University of California, Los Angeles, CA, 90025, USA

    Cindy Zhu

Authors
  1. **g He
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qingfeng Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. **n Hua
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Quanqing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ziwei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cindy Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wenyu Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

WY S designed the study; J H, QF X, and X H made the statistical analysis; QQ L and ZW C wrote the manuscript; C Z prepared the tables and figures. All the authors approved the final edition of the manuscript.

Corresponding author

Correspondence to Wenyu Shi.

Ethics declarations

Ethics approval

The study was approved by the institutional review board of National Center for Health Statistics.

Consent to participate

NA.

Consent for publication

NA.

Competing interests

The authors declare no competing interests.

Additional information

Responsible Editor: Lotfi Aleya

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

He, J., Xue, Q., Hua, X. et al. Association between environmental phenols and all-cause and cancer mortality. Environ Sci Pollut Res 30, 33432–33437 (2023). https://doi.org/10.1007/s11356-022-24415-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-022-24415-5

Keywords

Search

Navigation