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The functional role of P2 purinergic receptors in the progression of gastric cancer

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Abstract

Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and correlates with their function. Endogenous nucleotides including ATP, ADP, UTP, and UDP, as P2 purinergic receptors activators, participate in P2 purinergic signal transduction pathway. These activated P2 purinergic receptors regulate the progression of GC mainly by mediating ion channels and intracellular signal cascades. It is worth noting that there is a difference in the expression of P2 purinergic receptors in GC, which may play different roles in the progression of GC as a tumor promoting factor or a tumor suppressor factor. Among them, P2 × 7, P2Y2 and P2Y6 receptors have certain clinical significance in patients with GC and may be used as biological molecular markers for the prediction of patients with GC. Therefore, in this paper, we discuss the functional role of nucleotide / P2 purinergic receptors signal axis in regulating the progression of GC and that these P2 purinergic receptors may be used as potential molecular targets for the prevention and treatment of GC.

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Funding

These studies were supported by grants from the Project of Education Department of Jiangxi Province (GJJ2200238).

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Authors and Affiliations

  1. Thyroid surgery, Shenzhen Bao’an District Songgang People’s Hospital, Shenzhen City, 518105, China

    Fei-long Zou & **-xiong Ye

  2. The Second Affiliated Hospital, Nanchang University, Nanchang City, Jiangxi Province, 343000, China

    Ji-peng Liu, Cheng Zuo, Peng-fei He & Wen-jun Zhang

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  1. Fei-long Zou
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  2. Ji-peng Liu
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Contributions

Fei-long Zou: Completed the revision and data collation of this article. Ji-peng Liu: Completed the drawing and the data collection Cheng Zuo: Complete the references and revision. Peng-fei He: Complete the references and revision. **-xinog Ye: Completed the revision. Wen-jun Zhang: Completed the writing and the final manuscript, reviewed and revised the article.

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Correspondence to **-xiong Ye or Wen-jun Zhang.

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Ethical approval has been exempted by the Ethics Committee of the Second Affiliate Hospital of Nanchang University. All protocols were approved by the Animal Care and Ethics Committee, China.

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Zou, Fl., Liu, Jp., Zuo, C. et al. The functional role of P2 purinergic receptors in the progression of gastric cancer. Purinergic Signalling (2024). https://doi.org/10.1007/s11302-024-10000-7

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