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Identification and whole-genome characterization of a novel Porcine Circovirus 3 subtype b strain from swine populations in Vietnam

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Abstract

Porcine circovirus 3 (PCV3) is a novel circovirus detected in pigs suffering from porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, and multisystemic infection. In this study, we identified PCV3 infection in aborted fetuses and reported the full-length genome sequence of a PCV3 strain identified from southern Vietnam. The complete genome of this PCV3 strain is 2000 nucleotides in length. We found that it shares 98.5–99.25% sequence identity with other reference sequences and that it clusters with the PCV3b subtype. Several specific mutated sites were found to be unique to this Vietnamese PCV3b strain, including I14M in the Rep protein and K139R, I150F, and P169T in the Cap protein. The sequence data that have been made publically available as part of this study will help investigators to better understand the molecular characteristics, genetic diversity, and evolutionary history of PCV3. Careful and in-depth investigations into the epidemiology, pathogenicity, and the evolution of this novel virus is a matter of urgent economic and agricultural interest in Vietnam.

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Data availability

The complete genome sequence of the PCV3 NNH/DN7/2018 strain has been deposited in GenBank under the accession number MT847026.

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Acknowledgements

We thank Declan Clarke (Yale University) for comments that greatly improved the manuscript. We are grateful for technical support that we received from the HanViet Veterinary Diagnosis Laboratory at Nong Lam University.

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Authors and Affiliations

  1. Department of Infectious Diseases and Veterinary Public Health Faculty of Animal Science and Veterinary Medicine, Nonglam University HCMC, Thu Duc district, Ho Chi Minh City, Vietnam

    Ngoc Hai Nguyen & Duy Do Tien

  2. Han-Viet Veterinary Diagnosis Laboratory, Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam

    Ngoc Hai Nguyen, Trung Quan Nguyen & Thuy Trang Nguyen

  3. Research Center for Genetics and Reproductive Health, School of Medicine, Vietnam National University Ho Chi Minh City, Linh Trung ward, Thu Duc district, Ho Chi Minh City, Vietnam

    Minh Nam Nguyen

Authors
  1. Ngoc Hai Nguyen
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  2. Duy Do Tien
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  3. Trung Quan Nguyen
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  4. Thuy Trang Nguyen
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  5. Minh Nam Nguyen
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Contributions

N.H.N, D.D.T and M.N.N. designed the study; T.Q.N and T.T.N performed experiments; N.H.N and M.N.N. analysed the data; N.H.N, D.D.T and M.N.N. wrote the manuscript.

Corresponding authors

Correspondence to Ngoc Hai Nguyen or Minh Nam Nguyen.

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All authors have read the journal’s policy on disclosures of potential conflicts of interest, and we declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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The authors confirm that we have adhered to the ethical policies of the journal, as noted on the journal’s author guidelines page. No ethical approval was required as this is a review article with no original research data.

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Edited by Juergen A Richt.

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Nguyen, N.H., Do Tien, D., Nguyen, T.Q. et al. Identification and whole-genome characterization of a novel Porcine Circovirus 3 subtype b strain from swine populations in Vietnam. Virus Genes 57, 385–389 (2021). https://doi.org/10.1007/s11262-021-01844-x

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  • DOI: https://doi.org/10.1007/s11262-021-01844-x

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