The process of native blood coagulation was studied with the resonant-acoustic method using the technology of low-frequency piezothromboelastography. It is shown that the experimental curve of time dependence of the piezoelectric sensor signal amplitude reflects the change in the rheological properties of blood during coagulation. A formula is obtained that relates the change in the concentration of thrombin to the rate of change in the complex coefficient of blood viscosity. A method has been developed for assessing thrombin concentration during fibrinogenesis based on the technology of piezothromboelastography using a resonant-acoustic method for determining the viscoelastic properties of whole blood. The results of calculating the thrombin concentration by this method are compared with the results of the thrombin generation test.
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Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Fizika, No. 7, pp. 79–84, July, 2022.
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Demkin, V.P., Melnichuk, S.V., Demkin, O.V. et al. Method for Evaluating Thrombin Concentration Based on the Data of Monitoring the Viscoelastic Properties of Native Blood in the Process of Hemocoagulation. Russ Phys J 65, 1149–1154 (2022). https://doi.org/10.1007/s11182-022-02744-9
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DOI: https://doi.org/10.1007/s11182-022-02744-9